https://www.selleckchem.com/products/en450.html d disease progression and treatment efficacy.Hereditary xanthinuria was the first inherited purine metabolism disorder described. It is a rare pathology, which is most often asymptomatic and whose incidence is therefore underestimated. We report the case of a patient with an undetectable level of uric acid in the blood, discovered during a systematic biological assessment. This case report recalls the existence of this rare metabolic disorder, which is usually benign, but can lead to complications, and the importance of considering an abnormality of the purine cycle when discovering a hypo-uricemia. Cases of duodenal variceal hemorrhage after cirrhosis are rare, but patients have a higher mortality rate. There is currently no clinical guideline to address how such patients should choose preferred treatment. We retrospectively evaluated the clinical information of a 65-year-old male admitted to the Gastroenterology Department with gastrointestinal bleeding. The patient was eventually diagnosed with duodenal variceal bleeding after cirrhosis. We performed TIPS on the patients after the vital signs were stable. No varicose veins were seen by endoscopy during the 2-year follow-up. TIPS treatment is a good choice for patients with severe duodenal varices after cirrhosis. TIPS treatment is a good choice for patients with severe duodenal varices after cirrhosis. Hand, foot, and mouth disease (HFMD) is a self-limited disease caused mainly by enterovirus 71 and coxsackievirus A16; however, some cases have severe neurological complications, pulmonary edema, and fetal death. In this study, we analyzed the changes in natural killer (NK) cell subsets, their receptors, and serum inflammatory cytokines in children with HFMD. Peripheral blood samples were collected from 70 HFMD pediatric patients admitted Department of Infectious Diseases of our hospital from July 2016 to November 2017 and from 16 healthy children receiving physical e