https://www.selleckchem.com/products/CP-673451.html OBJECTIVE To compare uptake in the ordering of biosimilars at a Veterans' Affairs medical center (VAMC) to that at an academic medical center, where institutional incentives for infused medications differ. METHODS We performed a cross-sectional study of medical record data and estimated institutional financial incentives at two medical centers in Philadelphia 1) the University of Pennsylvania Health System (UPHS) and 2) the local VAMC. All ordering events for filgrastim or infliximab products were quantified over time, stratified by product (biosimilar versus reference product) and center. Financial incentives to the institutions over time were determined based on actual drug costs for the VAMC and average sales prices (ASPs) and Medicare Part B reimbursement rates for UPHS. RESULTS There were 15,761 infusions of infliximab, of which 99% were for the reference product. There was sharper decline in use of reference products at the VAMC; 62% of the 446 infliximab infusions ordered at the VAMC were for the reference product. ASPs were consistently lower for biosimilar infliximab products, but the estimated institutional financial incentives remained similar over time for biosimilar and reference infliximab at UPHS. At the VAMC, the costs for 100 mg vials of reference infliximab and infliximab-abda were $623.48 and $115.58, respectively a $507.90 (81%) savings per vial. CONCLUSIONS The uptake of infliximab biosimilars has been slow at an academic medical center, compared to a nearby VAMC, where financial savings are realized by the institution from its use. Slow adoption of biosimilar medications may impact the rates of decline in costs. This article is protected by copyright. All rights reserved.Cationic polymers exhibit high cytotoxicity via strong interaction with cell membranes. To reduce cell membrane damage, a hydrophilic polymer is introduced to the cationic nanoparticle surface. The hydrophilic polymer coating