https://www.selleckchem.com/ALK.html 035). The results and methodology of this study are informative to optimize the disinfection units of WRPs.Previous studies on long-term ozone (O3) variations in China have reported inconsistent conclusions on the role of meteorological factors in controlling said variations. In this study, we used an observation-based decomposition model to conduct an up-to-date investigation of the effects of meteorological factors on the variations in nitrogen dioxide (NO2) and O3 concentrations in China in the summer from 2013 to 2020. The variations in NO2 and O3 concentrations after removing the major meteorological effects were then analyzed to improve our understanding of O3 formation regimes. Ground measurements show that both NO2 and O3 concentrations decreased in eastern, central, and southeastern China (e.g., NO2 and O3 concentrations in Wuhan reduced by 4.3 and 6.2 ppb, respectively), which was not anticipated. Analyses of meteorological effects showed that reduced wind strength, decreased temperature, and increased relative humidity significantly reduced O3 concentrations in eastern and central China (e.g., by 10.5 ppb in Wuhan). After removing the major meteorological effects, the O3 trends were reversed in eastern and central China (e.g., increased by 4.9 ppb in Wuhan). The contrasting trends in NO2 and O3 concentrations suggest that their O3 formations were sensitive to volatile organic compounds (VOC-limited regime). In southeastern China, both NO2 and O3 concentrations decreased, implying that the O3 formation regimes changed to mixed sensitive or nitrogen oxide-limited (NOx-limited) regimes. The meteorological effects varied by region and may play a dominant role in controlling the long-term O3 variation. Our results indicate that the attribution of O3 variation to emission control without accounting for meteorological effects can be misleading.This study aims to investigate the spatial distribution of and temporal variation i