Previous research has shown that the highs and lows of sport fandom are more extreme for fans with strong levels of obsessive passion. The authors tested if this amplification effect applied to how hockey fans felt throughout a National Hockey League (NHL) playoff series. Fans of the Winnipeg Jets (N = 57) reported levels of harmonious and obsessive passion prior to the start of the 2019 NHL playoffs and then reported their feelings the day after each game of the first playoff round. The results supported the amplification hypothesis by showing that the impact of game result on both positive and negative feelings the day after a game was more extreme for fans with high obsessive passion. This moderating effect, however, appeared to be driven primarily by responses to losses.Tobacco habit still represents the leading preventable cause of morbidity and mortality worldwide. Heat-not-burn cigarettes (HNBCs) are considered as an alternative to traditional combustion cigarettes (TCCs) due to the lack of combustion and the absence of combustion-related specific toxicants. The aim of this observational study was to assess the effect of HNBC on endothelial function, oxidative stress and platelet activation in chronic adult TCC smokers and HNBC users. The results showed that both HNBC and TCC display an adverse phenotype in terms of endothelial function, oxidative stress and platelet activation. Future randomised studies are strongly warranted to confirm these data.
  To determine the predictive value of early transcranial color-coded sonography (TCCS) for intracranial hemorrhage (ICH) in patients with large artery occlusion (LAO) stroke of carotid circulation, who were submitted to endovascular therapy (EVT) with successful reperfusion.
 
  Retrospective study evaluating a cohort of consecutive stroke patients with LAO of the carotid circulation that were recanalyzed with EVT. We measured angle-corrected peak systolic velocities, end-diastolic velocities and mean flow velocities (PSV, EDV and MFV) of the symptomatic and asymptomatic middle cerebral artery (MCA). The ratio between MFV of the symptomatic MCA and MFV of the asymptomatic MCA (MCA-Ra) was calculated. Parenchymal hematoma in the 24 hours control CT was considered as ICH. Univariate associations and multivariate analyses were used to identify early independent predictors for ICH among TCCS findings.
 
  We included 234 patients, mean age 72.5 (SD 12.6) years, 52.1% male. The mean time between recanalization and TCCS was 12.3 hours (range 3-22). Patients who developed postinterventional ICH showed a higher MCA-Ra (1.02 ± 0.26 vs 1.16 ± 0,21, p=0.036). In multivariate analysis, only higher MCA-Ra remained independently associated with postinterventional ICH (OR 6.778, 95%CI 1.152-39.892, p=0.034). A value of MCA-Ra ≥ 1,05 was associated with ICH, showing a sensitivity of 81.3% and a specificity of 65.9%; the AUC based of the ROC analysis was 0.688 (95% CI 0.570-0.806).
 
  TCCS performed within the first 24 hours after stroke onset can help to predict hemorrhagic transformation in patients with LAO.
 TCCS performed within the first 24 hours after stroke onset can help to predict hemorrhagic transformation in patients with LAO.
  The Quality in Acute Stroke Care (QASC) protocol is a multidisciplinary approach to implement evidence-based treatment after acute stroke that reduces death and disability. This study sought to evaluate the cost-effectiveness of implementing the QASC protocol across Australia, from a healthcare and a societal perspective.
 
  A decision-analytic model was constructed to reflect one-year outcomes post-stroke, aligned with the stroke severity categories of the modified Rankin scale (mRS). Decision analysis compared outcomes following implementation of the QASC protocol versus no implementation. Population data were extracted from Australian databases and data inputs regarding stroke incidence, costs, and utilities were drawn from published sources. The analysis assumed a progressive uptake and efficacy of the QASC protocol over five years. Health benefits and costs were discounted by 5% annually. The cost of each year lived by an Australian, from a societal perspective, was based on the Australian Government's 'value of statistical life year' (AUD 213,000).
 
  Over five years, the model predicted 263,722 strokes among the Australian population. The implementation of the QASC protocol was predicted to prevent 1,154 deaths and yield a gain of 876 years of life (0.003 per stroke), and 3,180 quality-adjusted life years (QALYs) (0.012 per stroke).  https://www.selleckchem.com/products/Glycyrrhizic-Acid.html  There was an estimated net saving of AUD 65.2 million in healthcare costs (AUD 247 per stroke) and AUD 251.7 million in societal costs (AUD 955 per stroke).
 
  Implementation of the QASC protocol in Australia represents both a dominant (cost-saving) strategy, from a healthcare and a societal perspective.
 Implementation of the QASC protocol in Australia represents both a dominant (cost-saving) strategy, from a healthcare and a societal perspective.
  The study aimed to investigate whether N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentration and/or left atrial volume index (LAVI), as atrial cardiopathy biomarkers, were associated with infarct patterns on diffusion-weighted imaging in patients with embolic strokes of undetermined source (ESUS).
 
  We retrospectively evaluated patient with ESUS from our stroke registry between January 2018 and November 2019. Cut-off values for atrial cardiopathy biomarkers were defined as >250 pg/mL for NT-proBNP and >34 mL/m
  for LAVI. Eligible patients were then assigned to 3 groups and infarct patterns were compared according to their atrial cardiopathy markers Group 1 (no atrial cardiopathy markers), Group 2 (one marker), and Group 3 (both markers).
 
  Among 194 eligible patients with ESUS (76 women; mean age, 69.2 years), simultaneous increases of NT-proBNP concentration and LAVI were identified in 39 (20.1%). Group 3 had a significantly larger infarct volume, relative to Group 1 and Group 2 (P=0.0 cardioembolic subtypes and guiding treatment selection in patients with ESUS.Attentional control theory regards individuals with high anxiety as having deficits of inhibitory control when faced with distractors, especially under high-load conditions and with threatening distractors. Research on test anxiety has a long history, but the working memory (WM) characteristics of individuals with high test anxiety (HTA) remain unclear. We used two experiments to test the WM filtering ability of individuals with HTA, and the salient results were those of the contralateral delay activity amplitude rather than K score. The first experiment employed neutral distractors. HTA participants filtered distractors under low-load conditions but not under high-load conditions. Participants with low test anxiety (LTA) filtered distractors under high-load conditions but not under low-load conditions. The second experiment utilized threatening distractors. The participants with HTA exhibited deficits in their ability to filter neutral and threatening distractors, whereas the participants with LTA filtered both types of distractor.