e. the directed and weighted network, is more suitable and effective to reflect relationships in the financial field. In addition, the results also show that under the global financial crisis, the co-movement between financial sectors of a country/region and the global financial sector as well as between financial sectors and real economy sectors is increased. However, some sectors in particular Utilities and Healthcare are impacted slightly. This study tries to use the financial network indicators in modeling to study contagion channels on the real economy and the industry aggregation effects and suggest how network indicators can be practically used in financial fields.Dredging is considered a major threat/impedance to anadromous fish migrating to spawning habitat. Due to the perceived threat caused by dredging, environmental windows that restrict dredge operations are enforced within many rivers along the east coast. However, it is generally unknown how anadromous fish react to encountering an active dredge during spawning migrations. Atlantic sturgeon (ATS) are an endangered, anadromous species along the Atlantic slope of North America. To determine if and how an active dredge may affect ATS spawning migration, a Vemco Positioning System array was deployed around an active hydraulic-cutterhead dredge that adult ATS must traverse to reach spawning habitat in the James River, VA.  https://www.selleckchem.com/  Telemetry data showed that all ATS that entered the study area survived. ATS that migrated upstream during dredge operations (N = 103) traversed the dredge area and continued upstream to spawning habitat. Many ATS made multiple trips through the study area during dredge operations. There was no noticeable difference in swim behavior regardless of whether the dredge was absent or working within the study area. We suggest that dredging in the lower James River does not create a barrier for adult ATS migrating to spawning habitat or cause adults to significantly modify swim behavior. This is the first study to utilize fine-scale telemetry data to describe how an organism moves in relation to an active dredge. This methodology could be used to describe dredge-sturgeon interactions on different life stages and in other locations and could be expanded to other aquatic organisms of concern.The placental epigenome plays a critical role in regulating mammalian growth and development. Alterations to placental methylation, often observed at imprinted genes, can lead to adverse pregnancy complications such as intrauterine growth restriction and preterm birth. Similar associations have been observed in offspring derived from advanced paternal age fathers. As parental age at time of conception continues to rise, the impact of advanced paternal age on these reproductive outcomes is a growing concern, but limited information is available on the molecular mechanisms affected in utero. This longitudinal murine research study thus investigated the impact of paternal aging on genomic imprinting in viable F1 embryonic portions of the placentas derived from the same paternal males when they were young (4-6 months) and when they aged (11-15 months). The use of a controlled outbred mouse model enabled analysis of offspring throughout the natural lifetime of the same paternal males and excluded confounding factors like female age or infertility. Firstly, paternal age significantly impacted embryonic placental weight, fetal weight and length. Targeted bisulfite sequencing was utilized to examine imprinted methylation at the Kcnq1ot1 imprinting control region, with significant hypermethylation observed upon natural paternal aging. Quantitative real-time PCR assessed imprinted gene expression levels at various imprinting clusters, resulting in transcript level alterations attributable to advanced paternal age. In summary, our results demonstrate a paternal age effect with dysregulation at numerous imprinted loci, providing a mechanism for future adverse placental and offspring health conditions.[This corrects the article DOI 10.1371/journal.pone.0228499.].This paper proposes a new supervised method for blood vessel segmentation using Zernike moment-based shape descriptors. The method implements a pixel wise classification by computing a 11-D feature vector comprising of both statistical (gray-level) features and shape-based (Zernike moment) features. Also the feature set contains optimal coefficients of the Zernike Moments which were derived based on the maximum differentiability between the blood vessel and background pixels. A manually selected training points obtained from the training set of the DRIVE dataset, covering all possible manifestations were used for training the ANN-based binary classifier. The method was evaluated on unknown test samples of DRIVE and STARE databases and returned accuracies of 0.945 and 0.9486 respectively, outperforming other existing supervised learning methods. Further, the segmented outputs were able to cover thinner blood vessels better than previous methods, aiding in early detection of pathologies.[This corrects the article DOI 10.1371/journal.pone.0227475.].This study aimed to evaluate the analgesic efficacy of two dosage regimens using two different concentrations of buprenorphine in cats undergoing dental extractions. Twenty-three cats with oral disease (8.2 ± 2.2 years old; 4.9 ± 0.9 kg) were included in a prospective, blinded, randomized clinical trial. Cats randomly received either Simbadol (1.8 mg/mL; 0.24 mg/kg, subcutaneously, every 24h SG, n = 11) or Vetergesic (0.3 mg/mL; 0.02 mg/kg, intramuscularly, every 8h VG, n = 12) throughout the study. They were admitted at day 0, underwent oral examination/radiographs/treatment under general anesthesia (buprenorphine-propofol-isoflurane-meloxicam-local anesthetic blocks) at day 1 and discharged at day 4. Sedation and pain were scored using the dynamic interactive visual analog scale (day 1) and the Glasgow Composite Measure Pain Scale-Feline (CMPS-F; up to postoperative 8 hours at day 1, 8 am, 4 pm and midnight at days 2 and 3, and 8 am at day 4), respectively. Rescue analgesia was administered with hydromorphone (0.