Facing rapidly ageing populations, many Western countries aim to stimulate informal care provision as a way to meet the growing long-term care (LTC) demand. While various studies report the impact of providing informal care on the health of caregivers, it is less clear whether and to what extent this impact differs across countries. Using propensity score matching we match caregivers to similar non-caregiving individuals using four waves of the Dutch Study on Transitions in Employment, Ability and Motivation and the UK Household Longitudinal Study. The samples consist of 8129 Dutch and 7186 UK respondents, among which respectively 1711 and 1713 individuals are identified as caregivers. We explore whether the health impact of providing informal care differs by country once similar caregivers, in terms of the intensity of provided care, are compared. In both countries we find negative mental health effects of providing informal care. While these effects slightly differ by country, the main differences arise between subgroups of caregivers. Individuals that provide more than 20 hours of informal care per week, and those who face a double burden of care and full-time employment experience the most severe negative mental health effects. These results indicate that health effects of providing informal care are mediated by the specific caregiving context, allowing policymakers to use information on this context to provide targeted aid. In addition, it suggests that previously reported differences of caregiving effects across countries could be driven by differences in the population of informal caregivers which are shaped by countries' LTC policies.
  While it is likely that changing food environments have contributed to the rise in obesity rates, very few studies have explored historical trends in the food environment with little, if any, consideration at a nationwide level. This longitudinal, nationwide, and geospatial study aims to examine change over time inproximity tofood environments in all urban areas of New Zealand from 2005 to 2015.
 
  This study used high quality food outlet data by area-level deprivation within the three largest urban areas of Auckland, Christchurch and Wellington. We hypothesise that distance and travel time by car to supermarkets and fast-food outlets will have decreased over time with the most notable decreases in distance and time occuring in the most deprived areas of urban New Zealand. Change in major chain "fast-food" and "supermarket" outlets as identified by Territorial Authorities between 2005 and 2015 was analysed through the use of multilevel regression models.
 
  Findings show a decrease in distance and time to both fast-food outlets and supermarkets. The biggest decrease in distance for supermarkets was seen in the most deprived areas.
 
  Our findings contrast and add to previous evidence to demonstrate how changes in the food environment are not uniform, varying by area-level deprivation and by city with more equitable access to supermarkets occurring over time.
 Our findings contrast and add to previous evidence to demonstrate how changes in the food environment are not uniform, varying by area-level deprivation and by city with more equitable access to supermarkets occurring over time.Although most patients with metastatic or inoperable locally recurrent differentiated thyroid cancer have radioiodine-avid disease, the outcome for patients who do not achieve remission with radioiodine therapy is poor. Most centres use fixed empirical activities of radioiodine to treat these patients, which is in contrast to other areas of oncology, where there is a shift to more individualised treatment. The use of dosimetry techniques to calculate a more appropriate activity of radioiodine for each patient may increase the effectiveness of radioiodine therapy but is more complex, time-consuming and of unproven benefit. This review addresses some of the limitations of empirical radioiodine therapy, discusses existing dosimetry-based approaches to individualising therapy and proposes further work in this area. A prospective randomised controlled trial comparing empirical activities of radioiodine with activities guided by a combination of lesional dosimetry and maximum safe dose has not been carried out previously. Although considerable challenges in the design of such a study remain, a network of centres in the UK now has the potential to take this forward.
  The poor prognosis in patients with floating knee injuries is mainly contributed to articular involvement (Fraser's type Ⅱ). This study aims to evaluate and compare the functional outcomes among different Fraser's type Ⅱ floating knee injuries after surgical management.
 
  Twenty-seven patients with Fraser's type Ⅱ floating knee injuries (54 fractures) between September 2014 and December 2015 were enrolled prospectively in this study and were distributed according to Fraser's floating knee classification into three different groups as type ⅡA (ipsilateral femoral shaft and tibial intra-articular involvement, n=11), type ⅡB (ipsilateral tibial shaft and femoral intra-articular involvement, n=9) and type ⅡC (both femoral and tibial intra-articular involvement, n=7).  https://www.selleckchem.com/products/motolimod-vtx-2337.html  The differences among the groups were evaluated and compared. The functional outcomes of these injuries at one year were analyzed using Knee Injury and Osteoarthritis Outcome Score (KOOS) which covers 5 subscales of pain, other symptoms, activitiesd a better functional outcome as compared to those with type ⅡB and ⅡC fractures. This might be due to the open intra-articular involvement of the distal femur of the latter two fracture types.
 The results of this study show that patients with Fraser's type ⅡA fractures had a better functional outcome as compared to those with type ⅡB and ⅡC fractures. This might be due to the open intra-articular involvement of the distal femur of the latter two fracture types.
  To prospectively validate electromagnetic hand motion tracking in interventional radiology to detect differences in operator experience using simulation.
 
  Sheath task Six attending interventional radiologists (experts) and 6 radiology trainees (trainees) placed a wire through a sheath and performed a "pin-pull" maneuver, while an electromagnetic motion detection system recorded the hand motion. Radial task Eight experts and 12 trainees performed palpatory radial artery access task on a radial access simulator. The trainees repeated the task with the nondominant hand. The experts were classified by their most frequent radial artery access technique as having either palpatory, ultrasound, or overall limited experience. The time, path length, and number of movements were calculated. Mann-Whitney U tests were used to compare the groups, and P < .05 was considered significant.
 
  Sheath task The experts took less time, had shorter path lengths, and used fewer movements than the trainees (11.7 seconds ± 3.3 vs 19.