Reactivity measures the transient response of a system following a perturbation from a stable state. For steady states, the theory of reactivity is well developed and frequently applied. However, we find that reactivity depends critically on the scaling used in the equations. We therefore caution that calculations of reactivity from nondimensionalized models may be misleading. The attempt to extend reactivity theory to stable periodic orbits is very recent. We study reactivity of periodically forced and intrinsically generated periodic orbits. For periodically forced systems, we contribute a number of observations and examples that had previously received less attention.  https://www.selleckchem.com/products/6-benzylaminopurine.html  In particular, we systematically explore how reactivity depends on the timing of the perturbation. We then suggest ways to extend the theory to intrinsically generated periodic orbits. We investigate several possible global measures of reactivity of a periodic orbit and show that there likely is no single quantity to consistently measure the transient response of a system near a periodic orbit. Dexamethasone is the most clinically used glucocorticoid with an established role in the treatment of a wide spectrum of inflammatory-related diseases. While the therapeutic actions are well known, dexamethasone treatment causes a number of cardiovascular side effects, which are complex, frequent and, in some cases, clinically unnoticeable. Here, we investigated whether a therapeutic regimen of dexamethasone affects cardiac arrhythmogenesis, focusing on the contribution of Nox-derived reactive oxygen species (ROS). Male Wistar rats were treated with dexamethasone (2 mg/kg, i.p.) for 7 days. Afterward, hemodynamic measurements, autonomic modulation, left ventricular function, cardiac fibrosis, reactive oxygen species (ROS) generation, Nox protein expression, superoxide dismutase (SOD) and catalase activities, and arrhythmias incidence were evaluated. Here, we show that dexamethasone increases blood pressure, associated with enhanced cardiac and vascular sympathetic modulation. Moreover, a marked increase in thuring dexamethasone treatment, uncovering the pivotal role of ROS-generating NADPH oxidases for arrhythmias vulnerability. AIM To investigate the comparative effectiveness of renin-angiotensin system inhibitor (RASI) therapy on major clinical outcomes in patients with acute myocardial infarction (AMI) and prediabetes or diabetes after successful percutaneous coronary intervention (PCI) with newer-generation drug-eluting stents (DESs). METHODS A total of 11,962 patients with AMI were divided into six groups according to glycemic status and the presence or absence of RASI therapy normoglycemia (n = 3,080; RASI+ [n = 2,496], RASI- [n = 584]), prediabetes (n = 3,709; RASI+ [n = 2,944], RASI- [n = 765]), and diabetes (n = 5,173; RASI+ [n = 4,133], RASI- [n = 1,040]). The major endpoint was major adverse cardiac events (MACEs), defined as all-cause death, recurrent myocardial infarction (re-MI), or any repeat revascularization. RESULTS After adjustment, in RASI users, the cumulative incidence of re-MI of the diabetes group was significantly higher than that of the prediabetes group (aHR, 1.999; 95% CI, 1.153-3.467; p = 0.014). However, the cumulative incidences of MACEs, all-cause death, and any repeat revascularization were similar between the two groups during a 2-year follow-up period. CONCLUSIONS In the era of newer-generation DESs, RASI therapy did not reduce re-MI in patients with AMI and diabetes in this study. The development of primordial germ cells and gonads are determinants of reproductive health and fertility. Although the gonadal development process is similar for both genders, the gender-determining process and the mechanism of development of female and male gonads have different molecular mechanisms. Spermatogenesis and oogenesis are also included in this process for a healthy gonadal development. Many specific molecular signaling pathways play role in oogenesis and spermatogenesis and it is important to know at which stage these factors are effective, to understand the mechanism of a healthy gonadal development. With this review, we defined the importance of stage specific genes expressing during the events such as oogenesis and spermatogenesis with the prenatal and postnatal gonadal development. It will be important to know about the cellular signals involved in the control of the gonadal development. When ambiguous visual stimuli are presented to the eyes, conscious perception can spontaneously alternate across the competing interpretations - which was known as bistable perception. The spontaneous alternation of perception might indicate a connection between bistable perception and the dynamic interaction of brain networks. Here, we hypothesized that individual differences in perceptual dynamics may be reflected in dynamics of spontaneous neural activities. To test this idea, we investigated the relationship between the percept duration and the reconfiguration patterns of dynamic brain networks as measured by the functional connectivity (FC) during the resting state. Firstly, we found that individual difference of percept duration is associated with the temporal variability of the brain regions which were previously reported in studies of bistable perception, including anterior cingulate cortex (ACC), dorsal medial prefrontal cortex (DMPFC), dorsal lateral prefrontal cortex (DLPFC), superior parietal lobule (SPL), inferior parietal lobule (IPL), precuneus, insula, and V5. Secondly, there is a positive relationship between the temporal variability within the frontal-parietal network (FPN) and the percept duration. Thirdly, our results indicated that individual difference of bistable perception was related to the dynamic interaction between large-scale functional networks including default mode network (DMN), FPN, cingulo-opercular network (CON), dorsal attention network (DAN), salience network (SN), memory retrieval network (MRN). Altogether, our results demonstrated that inter-individual variability in bistable perception was associated with dynamic coupling of brain regions and networks involved in primary visual processing, spatial attention, and cognitive control.