05). The survival curves of gender, N stage and HCPT in combination of PYM chemotherapy had certain predictive value on the survival of patients with advanced OSCC. CONCLUSIONS Gender, N stage and HCPT in combination of PYM chemotherapy are independent risk factors for the survival of patients with advanced OSCC, and their survival curves can be used as a survival prediction model.PURPOSE：To investigate the effects of adenoid hypertrophy and maxillary sinus mucosal thickening on dentofacial development. METHODS：The selected subjects were divided into 4 groups according to the inclusion criteria group A (adenoid hypertrophy with maxillary sinus mucosal thickening), group B (adenoid hypertrophy without maxillary sinus mucosal thickening), group C (normal adenoid with maxillary sinus mucosal thickening), and group D (normal adenoid without maxillary sinus mucosal thickening). There were 20 subjects in each group, aging from 12 to 14 years old. The volume of maxillary sinus was measured by Mimics software. The adenoid, dental arch width, basal bone width and palatal height were measured by Dolphin software and dentofacial measurements were performed in the lateral cephalograms derived from cone-beam CT (CBCT). The data were analyzed with SPSS 24.0 software package. RESULTS： There was no significant difference in dentofacial measurements between group B and group D or group C and group D，except for ANB angle (P less then 0.05). Compared with group D, SNB, ANB, Wits appraisal, NA-APo, MP-HP, N-Me, S-Go/N-Me, N-ANS (perp HP), sum of three angles, Ar-Go of group A were significantly different (P less then 0.05). Neither left nor right maxillary sinus bony volume had significant difference between group B and D or group C and D. CONCLUSIONS： Both adenoid hypertrophy and maxillary sinus mucosal thickening have impact on dentofacial development.  https://www.selleckchem.com/products/sn-011-gun35901.html  Moderate or more severe adenoid hypertrophy with maxillary sinus mucosal thickening has greater impact on dentofacial development over adenoid hypertrophy or maxillary sinus mucosal thickening alone.PURPOSE The aim of this study was to evaluate condylar asymmetry in different skeletal patterns with cone-beam CT (CBCT). METHODS A total of 110 subjects aged from 18 to 30 years were selected from patients who had undergone CBCT examinations retrospectively. All the subjects were divided into three groups according to their skeletal patterns Class Ⅰ (Cl Ⅰ 0°≤ANB≤5°), Class Ⅱ (Cl Ⅱ ANB>5°) and Class Ⅲ (Cl Ⅲ ANB0.05). CONCLUSIONS Condyle-plus-ramus and the ramus asymmetry were affected by different skeletal patterns and the differences were caused by the height primarily. Patients of Class Ⅲ usually manifest mandibular protrusion while Class Ⅱ with mandibular retrognathism. Whether the degree of chin deviation differs according to the condylar asymmetry needs further investigation.PURPOSE To assess the influence of chin prominence on facial aesthetics with 3D images, to investigate the cognitive boundaries of chin prominence among orthodontists, general dentists and laypeople and compare the variance of their cognitive data, in order to provide quantitative reference for selection of clinical treatment. METHODS A 3D facial image was obtained by 3dMD. The soft tissue pogonion point was altered in 2 mm increments from -10 to 10 mm with Geomagic Wrap 2015, in order to represent retrusion and protrusion of the chin. These images were rated by orthodontists, general dentists and laypeople with VAS scores. Multivariate mixed linear regression was used to analyze the influence of gender, age and chin prominence on VAS scores, and whether there were differences among different groups with SAS 9.4 software package. ANOVA was also applied for comparison of each prominence. RESULTS This study was composed of 243 subjects, including 90 orthodontists, 101 general dentists and 52 laypeople. Chin prominence had significant effect on VAS scores. VAS scores decreased by 0.8910 for each unit increase in chin retrusion and decreased by 1.0958 for each unit increase in chin protrusion（P less then 0.01）. Desire for treatment started when chin retrusion exceeded 6 mm in orthodontist group and layperson group, 4 mm in general dentist group, and chin protrusion reached 6 mm in all groups（VAS scores less then 5）. There was no significant difference in the scores among orthodontists, general dentists and laypeople with the variance of chin prominence, and there was no significant difference in gender and age. CONCLUSIONS Chin prominence had significant effect on facial aesthetics. Soft tissue pogonion point located on the zero meridian was considered as the most attractive. Treatment needs increased significantly when chin protrusion reached 6 mm or chin retrusion exceeded 6 mm. There was no significant difference in the assessment among orthodontists, general dentists and laypeople.PURPOSE The main purpose of this study was to explore the experience associated with patient's decision to have or not have orthognathic treatment. METHODS Phenomenological methodology was used in this study. Ten patients were collected from January 2018 to March 2018, who were consulted in the Department of Oral and Craniomaxillofacial Surgery, Center of Craniofacial Orthodontics in Shanghai Ninth People's Hospital. They were interviewed by semi-structured, face to face in-depth interviews. Data were organized and analyzed by Colaizzi methods. RESULTS By reading, analysis and extraction, two topics, i.e, motivation and interference factor were obtained. CONCLUSIONS The treatment information service was limited. Further research is needed to improve the information services that support the treatment decision of malocclusion patients and help them to make the best choice.PURPOSE To investigate the clinical normal values of juveniles with normal occlusions of She and Han nationality in Lishui area of Zhejiang province, and compare the craniofacial characteristics between She and Han nationality. METHODS Two hundred juveniles of She nationality and 200 juveniles of Han nationality with normal occlusion were recruited. Lateral cephalometric radiographs were taken, and Downs cephalometric analysis was performed. The data were compared using paired samples t test with SPSS 12.0 software package. RESULTS There was no significant difference between males and females in the values of juveniles of both She and Han nationality. Compared to the male and female juveniles of Han nationality, MP-FH and U1-L1 of the She juveniles increased (P less then 0.05), while convexity decreased significantly (P less then 0.05). In addition, L1-MP of She female juveniles decreased significantly in comparison to that of Han female juveniles (P less then 0.05). There was no significant difference in other values between She and Han nationality.