Particularly, for the case with the largest initial landmark displacement of 15 ± 9 mm, the modified Demons algorithm had a registration error of 1.3 ± 1.1 mm, while the original Demons algorithm had a registration error of 3.6 ± 5.9 mm. We also qualitatively evaluated the modified Demons algorithm using two difficult cases in our routine clinic one lung case with large sliding motion and one head and neck case with large anatomical changes in air cavity. Visual evaluation on the deformed image created by the deformable image registration showed that the modified Demons algorithm achieved reasonable registration accuracy, but the original Demons algorithm produced distinct registration errors.A new method was developed to extract 129I from urine samples and measure it using accelerator mass spectrometry (AMS). The samples were pre-treated in an autoclave with hydrogen peroxide and were then acidified with nitric acid, followed by the precipitation of iodine as silver iodide (AgI) for measurement by AMS. This new procedure is substantially faster than previous methods for the extraction of iodine from urine and results in less chemical waste. The efficiency and reproducibility of this method were evaluated by using 125I as a yield tracer, eventually giving a recovery above 99%. To achieve this, several iterations of the method were required. The method was then successfully applied to measure 129I/127I isotopic ratios and 129I concentrations in 25 human urine samples. The AMS results for 129I in urine ranged 3.3 × 106 atoms/L to 884 × 106 atoms/L and the isotope ratio (129I/127I) in human urine ranged from 7.38 × 10-12 to 3.97 × 10-10 with a median of 1.29 × 10-10. This new method will be useful for investigations into the sources of iodine in the human diet and their relative importance for iodine sufficiency.The present work deals with locating a defect buried in a medium composed of a fluid matrix and small solid inhomogeneities. Classical imaging methods are based on delay and sum principle and would implicitly assume that the undamaged medium is homogeneous. The topological imaging framework however allows to take into account the heterogeneous nature of the undamaged medium and potentially to take advantage of it. In this work, it is applied to a demanding test case with different assumptions on the knowledge of the medium properties using a specifically-designed fluid-solid compatible imaging function. It leads to the definition of three imaging processes whose results are compared using respectively synthetic and experimental data. The results show the relevance of using the inhomogeneities' locations information, but not necessarily at all steps of the imaging process, leading to the definition of so called hybrid topological imaging method.Seagrasses are submerged marine angiosperms often prone to various biotic and abiotic stress factors in the marine environment. Our study investigated the response, adaptation and underlying tolerance mechanism of tropical seagrass Halodule pinifolia upon temperature stress (24°, 29°, 37°, and 45 °C) and evaluated the effect of temperature stress on net photosynthesis (ΔF/F'm) and dark respiration (Fv/Fm). In this study, metabolomic analysis of seagrass H. pinifolia upon heat stress has been performed using GC-MS based omics approach.  https://www.selleckchem.com/products/gsk-j4-hcl.html  As a result, the net photosynthetic efficiency (ΔF/F'm) was found significantly decreased upon heat stress, while the dark respiration rate was increased to 2.903 mg O2/g FW h-1 and 3.87 mg O2/g FW h-1 as compared to the control (24 °C), respectively. Metabolomic analysis showed heat stress could cause large metabolite variations with respect to sugar, amino acids and organic acids. Interestingly, three thermo-protective metabolites such as trehalose (sugar), glycine betaine (amino acid) and methyl vinyl ketone (organic acid) were profiled from H. pinifolia (45 °C) and is the first report on the occurrence of glycine betaine and methyl vinyl ketone from seagrasses and other aquatic species so far. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis demonstrated H. pinifolia exposed to heat stress lead to intense biochemical changes and caused significant variations in the heat responsive metabolic pathways. The present findings would facilitate the further research on identifying gene to metabolite networks for an effective management of seagrass conservation by genetic manipulation.The use of firearms by police in mental health-related events has not been previously researched in New Zealand. This study analysed reports of investigations carried out by the Independent Police Conduct Authority between 1995 and 2019. We extracted data relating to mental health state, demographics, setting, police response, outcome of shooting, and whether the individual was known to police, mental health services, and with a history of mental distress or drug use. Of the 258 reports analysed, 47 (18%) involved mental health-related events compared to 211 (82%) classified as non-mental health events. Nineteen (40.4%) of the 47 mental health events resulted in shootings, compared to 31 (14.8%) of the 211 non-mental health events. Of the 50 cases that involved shootings 38% (n = 19) were identified as mental health events compared to 62% (n = 31) non-mental health events. Over half of the mental health events (n = 11, 57.9%) resulted in fatalities, compared to 35.5% (n = 11) of the non-mental health events. Cases predominantly involved young males. We could not ascertain the ethnicity of individuals from the IPCA reports. Across all shooting events, a high proportion of individuals possessed a weapon, predominantly either a firearm or a knife, and just under half were known to police and had known substance use. Of the 19 mental health events, 47.4% (n = 9) of individuals were known to mental health services and in 89.5% (n = 17) of cases whānau (family) were aware of the individual's current (at the time of the event) mental health distress and/or history. These findings suggest opportunities to prevent the escalation of events to the point where they involve shootings. Lack of ethnicity data limits the accountability of the IPCA and is an impediment to informed discussion of police response to people of different ethnicities, and Māori in particular, in New Zealand.