The Active Kids voucher is a universal, state-wide voucher program, provided by the New South Wales (NSW) Government, Office of Sport. All school-aged children in NSW are eligible to receive a voucher to reduce registration costs of structured physical activity programs. This study explores reasons behind lower uptake among children who are overweight or obese, from cultural and linguistically diverse families and those living in low socio-economic areas.
 
  Participants were recruited through a convenience sample of parent/carers who participated in the NSW Health Go4Fun program. Qualitative data were collected using focus groups. The Framework method was adapted for the analysis, taking an interpretive phenomenological approach.
 
  Study participants (n=54) were all parents of children who were overweight or obese from both low and high socio-economic status (SES). Most reported speaking a primary language other than English at home (65%). Parents were mostly aware of the Active Kids program (91%) and reporh comprehensively address the remaining barriers, such as access and flexibility of programs with local stakeholders and activity providers.A new visible light induced step-growth polymerization of dibromoxylene, and diols using dimanganese decacarbonyl and diphenyliodonium salt is described. The polymerization is suggested to proceed by substitution reaction between dixylenium cations formed upon visible light irradiation in the presence of dimanganese decacarbonyl and diphenyl iodonium salt. For the described substitution reaction with diols as nucleophilic component, the scope of the process is studied.  https://www.selleckchem.com/products/monocrotaline.html  Furthermore, the presence of halide groups at chain ends of the resulting polymers provided the possibility of initiating subsequent free radical and free radical promoted cationic resulting in the formation of polyether-based block copolymers.Electrospinning is the most favourable method for production of polymer nanofibres. In this study, we prepared a samarium β-diketonate complex that incorporated pure, surface-roughened and coaxial hollow poly(methylmethacrylate) (PMMA) nanofibres through electrospinning. The successful incorporation of this samarium complex into the PMMA nanofibres with different architectures was elucidated through various structural and morphological studies. Optical investigations as well as other characterization techniques for the pure, surface-roughened and coaxial hollow PMMA nanofibres before and after incorporating the samarium β-diketonate complex explained the host matrix nature of the PMMA nanofibres. Photoluminescence properties of the pure and structurally modified PMMA nanofibres were enhanced two or three times after incorporating the samarium complex into the fibre. Comparison of the optical properties between the pure and structurally modified PMMA nanofibres incorporating the samarium β-diketonate complex demonstrated the structural and optical improvements as well as the better host matrix nature of the surface-roughened and coaxial hollow PMMA nanofibres over pure PMMA nanofibres for the samarium β-diketonate complex. These optical enhancements make these materials applicable for various optical devices.
  Homozygous and compound heterozygous variants in glucocerebrosidase (GBA) can cause Gaucher disease (GD), whereas heterozygous variants increase the risk of developing Parkinson's disease (PD). GD patients display altered peripheral immune proteins. However, it is unknown if these are altered in GBA carriers with PD.
 
  To determine whether plasma cytokines and immune biomarkers associated with GD are also altered in GBA carriers with or without PD.
 
  Inflammatory cytokines and established GD biomarkers, ferritin, CD162, CCL18, and chitotriosidase (28 biomarkers) were measured in GBA pathogenic variant carriers with (n = 135) and without (n = 83) PD, and non-carriers with (n = 75) and without PD (n = 77).
 
  PD patients with biallelic pathogenic variants in GBA had elevated plasma levels of ferritin, CCL18, and MIP1α. These biomarkers were not elevated in heterozygous GBA carriers.
 
  GD plasma biomarkers are not promising candidates for stratifying the risk for PD in carriers of heterozygous GBA pathogenic variants. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
 GD plasma biomarkers are not promising candidates for stratifying the risk for PD in carriers of heterozygous GBA pathogenic variants. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.Abscisic acid (ABA), a well-known natural phytohormone reportedly exerts anti-inflammatory and anti-oxidative properties in diabetes and colitis. However, the efficacy of ABA against allergic airway inflammation and the underlying mechanism remain unknown. Herein, an OVA-induced murine allergic airway inflammation model was established and treated with ABA in the presence or absence of PPAR-γ antagonist GW9662. The results showed that ABA effectively stunted the development of airway inflammation, and concordantly downregulated OVA-induced activation of NLRP3 inflammasome, suppressed oxidative stress and decreased the expression of mitochondrial fusion/fission markers including Optic Atrophy 1 (OPA1), Mitofusion 2 (Mfn2), dynamin-related protein 1 (DRP1) and Fission 1 (Fis1). Moreover, ABA treatment further increased OVA-induced expression of PPAR-γ, while GW9662 abrogated the inhibitory effect of ABA on allergic airway inflammation as well as on the activation of NLRP3 inflammasome and oxidative stress. Consistently, ABA inhibited the activation of NLRP3 inflammasome, suppressed oxidative stress and mitochondrial fusion/fission in LPS-stimulated Raw264.7 cells via PPAR-γ. Collectively, ABA ameliorates OVA-induced allergic airway inflammation in a PPAR-γ dependent manner, and such effect of ABA may be associated with its inhibitory effect on NLRP3 inflammasome and oxidative stress. Our results suggest the potential of ABA or ABA-rich food in protecting against asthma.