Additionally, considerable amendments in hormonal levels (testosterone, luteinizing and follicle-stimulating hormone) and sperm characteristics were spotted. Further, histological variations in the testes section were detected and this supports the biochemical observations. Otherwise, rats supplemented with bromelain alone diminished TBARS and H
  O
  and augmented mostly other parameters. Furthermore, supplementation with bromelain before Al intoxication in rats exhibited worthy betterment in oxidative stress markers, hormones, and sperm quality compared to Al treated group.
 
  In conclusion, bromelain had a powerful protective role against Al-induced testicular dysfunction so, it represents a novel approach in metal toxicity processing.
 In conclusion, bromelain had a powerful protective role against Al-induced testicular dysfunction so, it represents a novel approach in metal toxicity processing.Herein, we prepared novel reactive oxygen species (ROS) responsive core crosslinked (CCL/TK) polycarbonate micelles conveniently by click reaction between amphiphilic diblock copolymer poly(ethylene glycol)-poly(5-methyl-5-propargylxycar-bonyl-1,3-dioxane-2-one) (PEG-PMPC) with pendant alkynyl group and thioketal containing azide derivative bis (2-azidoethyl) 3, 3'- (propane-2, 2-diylbis (sulfanediyl)) dipropanoate (TK-N3). The CCL/TK micelles were obtained with small size of 146.4 nm, showing excellent stability against dilution and high doxorubicin (DOX) loading. In vitro toxicity tests demonstrated that the obtained CCL/TK micelles have good biocompatibility and low toxicity with cell viability above 95 %. Furthermore, DOX-loaded CCL/TK micelles showed significantly superior toxicity with IC50 values for HeLa and MCF-7 cells about 3.74 μg/mL and 3.91 μg/mL, respectively.  https://www.selleckchem.com/products/ipi-549.html  Confocal laser scanning microscope (CLSM) and flow cytometry showed excellent internalization efficiency and intracellular drug release of DOX-loaded CCL/TK micelles. The obtained ROS-responsive CCL/TK micelles showed great potential for anticancer drug delivery.There are few studies in Greece on sexual offenders. The research aims to contribute knowledge and information related to psychopathology, psychosocial factors and the sexuality of this particular category of convicts for sexual offenses. The search took place in the Greek prison in Grevena, where the largest number of sexual offenders are being held. This is a quantitative study and descriptive and inferential statistical methods were used. The study involved 127 sexual detainees and used the STAI, BDI, EPQ, SCL-90 questionnaires and a special sexual behavior questionnaire. The reliability of the tools was high as the lowest price of Cronbach alpha was equal to 0.733 (STAI) and the highest was 0.975 (SCL-90). The Special Sexual Behavior Questionnaire was 0.877 reliable. RESULTS The results of the research confirmed the heterogeneity of the population of sexual perpetrators in many categories of data. The importance of some factors such as abuse in childhood, substance use, difficulty in having close relationant decrease in the use of pornographic material with adult women and minors, while the use of pornographic material with homosexual content increased. CONCLUSIONS The investigation of psychopathology, sexual behaviour and those psychosocial factors that characterize and determine the lives of sexual offenders, offers important data and knowledge on which we will rely for the development of therapeutic and preventive programs. Future research on sex offenders should focus on further research on psychopathology and how to think about it, as well as the possibility of using reliable relapse prevention tools to protect society as a whole.Deep auto-encoders (DAEs) have achieved great success in learning data representations via the powerful representability of neural networks. But most DAEs only focus on the most dominant structures which are able to reconstruct the data from a latent space and neglect rich latent structural information. In this work, we propose a new representation learning method that explicitly models and leverages sample relations, which in turn is used as supervision to guide the representation learning. Different from previous work, our framework well preserves the relations between samples. Since the prediction of pairwise relations themselves is a fundamental problem, our model adaptively learns them from data. This provides much flexibility to encode real data manifold. The important role of relation and representation learning is evaluated on the clustering task. Extensive experiments on benchmark data sets demonstrate the superiority of our approach. By seeking to embed samples into subspace, we further show that our method can address the large-scale and out-of-sample problem. Our source code is publicly available at https//github.com/nbShawnLu/RGRL.This paper investigates the problem of global μ-synchronization of impulsive pantograph neural networks. In this paper, new concept of ν-asymptotic periodic impulsive interval Tasyν is proposed for pantograph networks. By employing the Lyapunov method combined with the mathematical analysis approach for impulsive systems, some useful criteria are derived to guarantee the global μ-synchronization of coupled pantograph neural networks when the asymptotic logarithmic periodic impulsive interval Tasyln less then ∞ and Tasyln=∞, respectively. Especially when Tasyln=∞, as long as the networks are unstable, impulsive control cannot achieve synchronization regardless of the size of the impulse gain. Numerical simulations are exploited to illustrate our theoretical results.The aim of this systematic review and meta-analysis was to investigate the efficacy of ginger supplementation on circulating levels of C-reactive protein (CRP), high sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-α), soluble intercellular adhesion molecule (sICAM), and interleukin-6 (IL-6) concentrations in randomized controlled trials (RCTs). The search included PubMed-Medline, EMBASE, Scopus, Web of Science and Cochrane Library databases to identify randomized clinical trials on the effect of ginger supplementation on circulation levels of CRP, hs-CRP, IL-6, sICAM, and TNF-α published up until February 1st, 2020. We did not restrict articles based on language of publication. Standard mean differences and 95% confidence intervals were calculated for net changes in inflammatory mediators using a random-effects model. Sixteen RCTs comprising 1010 participants were found to be eligible for this meta-analysis. There was a significant reduction of circulating CRP (SMD -5.11, 95% CI -7.91, -2.