japonicus was significant decreased while the IAP and Lys expression of L. vannamei still maintained at a high level. The results suggested that the metabolic rate of MPs in P. monodon was significantly higher than that in M. japonicus and L. vannamei. The tolerance of L. vannamei to MPs was higher than that of P. monodon and M. japonicas and their different responses in anti-microbial gene might be one of the reasons for the difference of their mortality. This study provides the first report comparing the organism response distinction in cultured shrimp and enriching to the understanding of the impact of MPs on ecosystem.The Bokashi leachate (BL) is a by-product from the anaerobic digestion of food waste, following the Bokashi composting method. Bokashi leachate is acidic and it contains effective microorganisms hence it has potential to be a functional feed additive to the plant proteins based diets for fish farming. This study evaluated the growth performance and feed utilization of the red tilapia (Oreochromis sp.) fingerlings fed with the BL supplemented soybean meal (SBM) based diets. After an 8-week feeding trial, fish fed with the 5% BL supplemented SBM diet attained the highest weight gain. This result was significantly higher (p 0.05) to those fed with the control full fish meal (FM) diet. Generally, dietary inclusion of BL enhanced the fish feed intake on the SBM diet but it did not show clear sign of improvement in their feed utilization. In addition, no significant difference was found across the hepatosomatic index and viscerosomatic index from all dietary treatments. These outcomes concluded that dietary inclusion of BL can enhance the feed intake and growth performance of the red tilapia fingerlings fed with the SBM based diet without compromising their health, and the optimum BL inclusion level was 5%. Nevertheless, further study on the properties and substances content of the BL produced from different types and ratios of food waste is strongly recommended. In this study, BL was also discovered to be capable of reducing the crude fiber content in the SBM diets. Such observation deserves a further exploitation on the application of BL to manipulate the crude fiber content in the plant proteins based diets in fish farming.Considering the live SARS-CoV-2 was detected and isolated from the excrement and urine of infected patients, the potential public health risk of its waterborne transmission should be paid broad and close attention. The purpose of the current study is to investigate the associations between COVID-19 incidences and hydrological factors such as lake area, river length, precipitation and volume of water resources in 30 regions of China. All confirmed cases for each areas were divided into two clusters including first cases cluster driven by imported cases during the period of January 20th to January 29th, 2020 and second cases cluster driven by local cases during the period of January 30th to March 1st, 2020. Based on the results of descriptive analysis and nonlinear regression analysis, positive associations with COVID-19 confirmed numbers were observed for migration scale index (MSI), river length, precipitation and volume of water resources, but negative associations for population density. The correlation coefficient in the second stage cases cluster is apparently higher than that in the first stage cases cluster. Then, the negative binomial-generalized linear model (NB-GLM) was fitted to estimate area-specific effects of hydrological variables on relative risk (RR) with the incorporation of additional variables (e.g., MSI) and the effects of exposure-lag-response. The statistically significant associations between RR and river length, the volume of water resources, precipitation were obtained by meta-analysis as 1.24 (95% CI 1.22, 1.27), 2.56 (95% CI 2.50, 2.61) and 1.59 (95% CI 1.56, 1.62), respectively. The possible water transmission routes of SARS-CoV-2 and the potential capacity of long-distance transmission of SARS-CoV-2 in water environment was also discussed. Our results could provide a better guidance for local and global authorities to broaden the mind for understanding the natural-social system or intervening measures for COVID-19 control at the current or futural stage.Genetic and environmental factors are thought to influence the activity of systemic lupus erythematosus (SLE), but relatively little is known about the effects of ambient air pollution. Using pollution data from air monitoring stations in the urban centers in Santiago Chile, along with daily patient hospitalization data from 2001 to 2012, an association between ambient air pollution and daily hospital admissions for SLE was tested using generalized linear models. Averaged over all regions pollutant mean 24 h concentrations were 0.96 ppm carbon monoxide (CO), 64 ppb ozone (O3), 43 ppb nitrogen dioxide (NO2), 9 ppb sulphur dioxide (SO2), 29 μg/m3 particulate matter ≤ 2.5 μm in mean aerodynamic diameter (PM2.5), and 67 μg/m3 particulate matter ≤ 10 μm in diameter (PM10). The relative risk estimates in single pollutant models for an interquartile range (IQR) increase in pollutant were RR = 1.34 (95% CI 1.06-1.83) for SO2, RR = 1.60 (95% CI 1.15-2.24) for CO, and RR = 1.41 (95% CI 1.14-1.86) for PM2.5. In two-pollutant models, the significance of SO2 and PM2.5 persisted despite adjustments for each of the other measured pollutants. These findings suggest that acute increases in air pollution increase the risk of hospitalization with a primary diagnosis of SLE.The spread of pharmaceutically active chemicals (PACs), such as antibiotics and estrogenic hormones from animal manures can pose threats to the ecologic environment. In this work, animal manure samples were collected from 71 concentrated animal feedlots in Northern China and investigated for 24 antibiotics and 4 estrogenic hormones. Results showed that these micropollutants were ubiquitous in manures with the concentration ranges of undetectable (ND)-543,445 μg/kg (mean 44,568 μg/kg) for antibiotics and ND-249.8 μg/kg (mean 24.78 μg/kg) for estrogens.  https://www.selleckchem.com/products/FK-506-(Tacrolimus).html  There was a significant variation in the amounts of PACs in different animal manures. The amounts of antibiotics in manures had following order swine (83,177 μg/kg) >chicken (52,932 μg/kg) >beef (37,120 μg/kg) >dairy (305 μg/kg), while the estrogens in dairy (mean 39.27 μg/kg) and chicken manures (mean 40.08 μg/kg) were higher than those in beef (2.7 μg/kg) and swine manures (1.8 μg/kg). Based on the estimated farmland application rate of manure, antibiotics and estrogens may cause high ecological risks to terrestrial organisms according to the risk quotient evaluation.