Despite the complexity of the lesions treated, use of simulation qualitatively enhanced surgeon confidence. There were no perioperative complications for patients treated with open surgery.
 
  Surgical simulation may aid in the treatment of complex pediatric aneurysmal malformations.
 Surgical simulation may aid in the treatment of complex pediatric aneurysmal malformations.
  Despite the significant role that stress plays in clinical care and education and the potential benefit of virtual reality (VR) as a simulation modality, there is a dearth of literature on stress and VR. The results of this scoping review have shown the positive effect that VR simulation can have on mitigating the negative aspects of stress during simulation and clinical training as well as improving provider performance and affect. Virtual reality technology, and immersive VR specifically, has the potential to powerfully transform how simulation education is being conducted. Because of this, the authors encourage researchers to put more focus into this topic and in determining how VR can be used to provide simulations with excellent training and a strong sense of presence for the purpose of addressing how stress can impact learners' clinical training and performance.
 Despite the significant role that stress plays in clinical care and education and the potential benefit of virtual reality (VR) as a simulation modality, there is a dearth of literature on stress and VR. The results of this scoping review have shown the positive effect that VR simulation can have on mitigating the negative aspects of stress during simulation and clinical training as well as improving provider performance and affect. Virtual reality technology, and immersive VR specifically, has the potential to powerfully transform how simulation education is being conducted. Because of this, the authors encourage researchers to put more focus into this topic and in determining how VR can be used to provide simulations with excellent training and a strong sense of presence for the purpose of addressing how stress can impact learners' clinical training and performance.
  This article documents the creation and implementation of a unique approach to translational simulation in a large, tertiary hospital setting. By creating a simulation consultation service, the ethos of translational simulation can be made more accessible to all areas of the hospital. Through the referral-consultation process, simulation exercises can be specifically designed, in conjunction with the referring individual/team, to directly address specific objectives. The service provides a wide range of multiprofession, multidiscipline simulation expertise and ensures simulation facilitation in a consistent, safe, and objective specific manner accessible to all areas of a large, hospital setting.
 This article documents the creation and implementation of a unique approach to translational simulation in a large, tertiary hospital setting. By creating a simulation consultation service, the ethos of translational simulation can be made more accessible to all areas of the hospital. Through the referral-consultation process, simulation exercises can be specifically designed, in conjunction with the referring individual/team, to directly address specific objectives. The service provides a wide range of multiprofession, multidiscipline simulation expertise and ensures simulation facilitation in a consistent, safe, and objective specific manner accessible to all areas of a large, hospital setting.
  Failure of airway management remains a significant source of morbidity and mortality.  https://www.selleckchem.com/products/LY2603618-IC-83.html  Advanced airway management has been addressed effectively by simulation-based training. However, simulation of difficult airways in manikins is limited by the pre-set conditions provided by the manufacturer. Life-like conditions in the form of the softness of the tissue and true anatomy as seen in cadaver models are needed to create simulated models with a closer resemblance to real patients. The goal of this study was to determine the feasibility of simulating difficult airway from submandibular abscess in cadaver models by surgical modification of the cadaver heads for use in enhanced experiential learning of the management of difficult airways.
 
  The cadaver heads were modified surgically to simulate a submandibular abscess. The models were used in an airway course where participants provided feedback on the realistic nature of the model and its benefits for difficult airway training. The ease of tracheal intubation of the models with the assistance of video laryngoscopy was assessed.
 
  The modified cadavers were acceptable in simulating difficult airway as demonstrated by the feedback from the participants. All participants (100% [95% confidence interval = 89.1%-100%]) found the models to be realistic and beneficial for difficult airway training. A good proportion (56.3%) felt that the intubation technique was made easier with the video laryngoscopy.
 
  Cadavers can be modified to simulate pathologies associated with difficult airways. These models can be used to enhance experiential learning and the management of difficult airways.
 Cadavers can be modified to simulate pathologies associated with difficult airways. These models can be used to enhance experiential learning and the management of difficult airways.
  Interindividual variations in the efficacy of antiseizure medications make epilepsy treatment challenging. This is due to genetic factors such as gene polymorphisms in Adenosine-triphosphate (ATP)-binding cassette sub-family B member 1 (ABCB1). In this article, the impact of polymorphisms in the P-glycoprotein-encoding gene, ABCB1 (C1236T, G2677T/A, and C3435T), on levetiracetam disposition was evaluated in Uygur Chinese children with epilepsy.
 
  MDR1 C3435T polymorphism was analyzed by polymerase chain reaction-fluorescence staining in situ hybridization. The χ test and Fisher exact test were used to analyze the allelic and genotypic distribution of ABCB1, C1236T, G2677T, and C3435T between the drug-resistant and drug-responsive groups. Differences in steady-state and dose-corrected levetiracetam serum concentrations between the different genotypes were analyzed using 1-way analysis of variance and Mann-Whitney test.
 
  Total 245 Uygur children with epilepsy were analyzed [drug-resistant, n = 117 (malesfemales = 5364) and drug-responsive, n = 128 (malesfemales = 7652)].