https://www.selleckchem.com/products/n-ethylmaleimide-nem.html 47; p = 0.03; without using BMD, HR, 1.54; p = 0.01). A history of recurrent falls was also a significant predictor of both incident MOFs and hip fractures. However, when the subjects were stratified based on age group, a history of falling and recurrent falls were strong predictors of MOFs and hip fractures in the younger but not the older subgroup. A fall history can predict incident fracture independently of FRAX probability, particularly in subjects younger than 75years old. A fall history can predict incident fracture independently of FRAX probability, particularly in subjects younger than 75 years old. Being physically active has multiple salutary effects on human health, likelymediated by changes in energy metabolism. Recent reviews have summarized metabolomic responses to acute exercise. However, metabolomic profiles of individuals who exercise regularly are heterogeneous. We conducted a systematic review to identify metabolites associated with physical activity (PA), fitness, and sedentary time in community-dwelling adults and discussed involved pathways. Twenty-two studies were eligible because they (1) focused on community-dwelling adults from observational studies; (2) assessed PA, fitness, and/or sedentary time, (3) assessed metabolomics in biofluid, and (4) reported on relationships of metabolomics with PA, fitness, and/or sedentary time. Several metabolic pathways were associated with higher PA and fitness and less sedentary time, including tricarboxylic acidcycle, glycolysis, aminoacyl-tRNA biosynthesis, urea cycle, arginine biosynthesis, branch-chain amino acids, and estrogen metabolism. Ling physically active and less sedentary indicate active skeletal muscle biosynthesis supported by enhanced oxidative phosphorylation and glycolysis and associated with profound changes in lipid and estrogen metabolism. Future longitudinal studies are needed to understand whether these metabolomic chang