In PSMA-ligand PET/CT imaging, standardized evaluation frameworks and image-derived parameters are increasingly used to support prostate cancer staging. Clinical applicability remains challenging wherever manual measurements of numerous suspected lesions are required. Deep learning methods are promising for automated image analysis, typically requiring extensive expert-annotated image datasets to reach sufficient accuracy. We developed a deep learning method to support image-based staging, investigating the use of training information from two radiotracers.
 
  In 173 subjects imaged with 
  Ga-PSMA-11 PET/CT, divided into development (121) and test (52) sets, we trained and evaluated a convolutional neural network to both classify sites of elevated tracer uptake as nonsuspicious or suspicious for cancer and assign them an anatomical location. We evaluated training strategies to leverage information from a larger dataset of 
  F-FDG PET/CT images and expert annotations, including transfer learning and combined raining examples from a different radiotracer improved performance. The investigated methods are promising for enabling efficient assessment of cancer stage and tumor burden.
 The evaluated algorithm showed good agreement with expert assessment for identification and anatomical location classification of suspicious uptake sites in whole-body 68Ga-PSMA-11 PET/CT. With restricted PSMA-ligand data available, the use of training examples from a different radiotracer improved performance.  https://www.selleckchem.com/products/isa-2011b.html  The investigated methods are promising for enabling efficient assessment of cancer stage and tumor burden.
  Comminuted inferior patellar pole fractures are challenging injuries and require effective treatment due to the extension mechanism of the knee. This study aims to evaluate the outcome of above fractures treated with a modified technique of cerclage-wire-augmented separate vertical wiring (SVW) with cerclage wiring passed through the proximal patella.
 
  Retrospective analysis (1/2017-1/2020) were performed for patients that were treated with three SVWs through the posterior margin of proximal fragment and directly to the anterosuperior border of patella, combined with a cerclage wiring passed through the proximal patella. Patients who experienced comminuted inferior patellar pole fractures within 3weeks were included, and the outcome was evaluated radiologically and clinically by Bostman score after a minimum of 12months following surgery. Further evaluation included the operation time and complication rate.
 
  A total of 20 patients (10 males, 10 females) with a mean age of 54 ± 14.5years (26-83years) and a follow-up of 18.9 ± 6.6months (12-36months) were evaluated. The average operation time was 45.7 ± 8.8min (30-60min). At final follow-up, the average range of motion was 131.3° ± 3.5° (125°-135°), and the mean Bostman score was 29.4 ± 0.7 points (28-30) and graded excellent in all cases. Two patients experienced occasional giving way of the knee. Radiologically no loss of reduction, implant breakage, nonunion or skin irritation was observed.
 
  The cerclage-wire-augmented SVW with cerclage wiring passed through the proximal patella appears to be a safe and simple technique which can effectively treat the comminuted inferior patellar pole fractures.
 The cerclage-wire-augmented SVW with cerclage wiring passed through the proximal patella appears to be a safe and simple technique which can effectively treat the comminuted inferior patellar pole fractures.Binaural beat (BB) is a promising technique for memory improvement in elderly or people with neurological conditions. However, the related modulation of cortical networks followed by behavioral changes has not been investigated. The objective of this study is to establish a relationship between BB oscillatory brain activity evoked by stimulation and a behavioral response in a short term memory task. Three Groups A, B, and C of 20 participants each received alpha (10 Hz), beta (14 Hz), and gamma (30 Hz) BB, respectively, for 15 min. Their EEG was recorded in pre, during, and post BB states. Participants performed a digit span test before and after a BB session. A significant increase in the cognitive score was found only for Group A while a significant decrease in reaction time was noted for Groups A and C. Group A had a significant decrease of theta and increase of alpha power, and a significant increase of theta and decrease of gamma imaginary coherence (ICH) post BB. Group C had a significant increase in theta and gamma power accompanied by the increase of theta and gamma ICH post BB. The effectiveness of BB depends on the frequency of stimulation. A putative neural mechanism involves an increase in theta ICH in parieto-frontal and interhemispheric frontal networks.Agricultural land accounts for 37% of the world's terrestrial area, and the multiple functions of agroecosystems-providing food, soil and water retention, and various cultural services-are of great importance for sustainable land management. To ensure that multifunctionality, payment for ecosystem services (PES) schemes have been developed for heterogeneous agroecosystems. However, the effects of the schemes have not been fully measured because, in most cases, they have been implemented as action-oriented programs rather than outcome-based payments. This study examines the effect of a community-based PES (CB-PES) program on the prevention of farmland abandonment to assess the agricultural outcomes of PES implementation in hilly and mountainous areas in Japan. We interviewed farmers in enrolled communities, mapped enrolled plots, and analyzed agricultural census data on the socioeconomic characteristics and farmland management conditions of 12,261 farmers in 960 agricultural communities in a typical hilly and mountainous area of Noto Peninsula in northern Japan. The results confirm that direct payments are effective in enhancing community management and in preventing additional farmland abandonment. In addition, we found that several socioeconomic and environmental factors at both the community and farmer levels-including geographical conditions, collective management activities, absence of successors, farm scale, and off-farm income dependency-simultaneously affected the farmland abandonment process. Specifically, collective practices within and between communities is a significant factor in preventing farmland abandonment more than collaboration with outsiders. Considering the depopulation and aging of rural communities throughout Japan, intercommunity enrollment could improve the effectiveness of CB-PES by upscaling the current payment scheme to maintain community functions.