Across all women there was a weak relationship between bile acid concentrations and itch severity.
 
  There was no subgroup of women with ICP in whom a beneficial effect of treatment with UDCA on bile acid concentration or itch score could be identified. This confirms that its routine use in women with this condition for improvement of bile acid concentration or itch score should be reconsidered.
 
  PITCHES No group of women with ICP has been found in whom UDCA reduces bile acid concentrations or pruritus.
 PITCHES No group of women with ICP has been found in whom UDCA reduces bile acid concentrations or pruritus.
  Recent reports have highlighted the emergence of 'wasp dope' as an issue of concern, but epidemiological evidence is lacking. Wasp dope is a crystalline substance created by electrifying pyrethroid-containing insecticides (e.g. wasp sprays) that may give users a methamphetamine-like 'rush'. This paper describes wasp dope use and correlates of use in a sample of people who use drugs (PWUD) in Appalachian Kentucky, a region that has been an epicenter of opioid use and related harms in the United States.
 
  Respondent-driven sampling and targeted street outreach were used to recruit PWUD. Eligibility criteria included being aged at least 18years, residing in one of five Appalachian Kentucky counties, and having either used opioids or injected any drug to get high in the prior 30days. Interviewer-administered surveys queried participants' (n=278) recent (past 6months) wasp dope use, other substance use and demographic characteristics. Prevalence ratios (PR) were estimated using generalized estimating equations aomelessness, transportation access, methamphetamine use and injection drug use.
 Among people who use drugs in rural Kentucky, USA, more than one in six people surveyed reported using wasp dope in the past 6 months, nearing the percentage using cocaine/crack (20%) and fentanyl/carfentanil (25%). Wasp dope use was higher among men and strongly associated with homelessness, transportation access, methamphetamine use and injection drug use.Merkel cell carcinoma (MCC) is a rare but very aggressive neuroendocrine cancer of the skin, with very limited therapeutic options. Although immunotherapy is effective in some cases, there is an unmet need for new therapeutic approaches in MCCs. In this issue of EMBO Molecular Medicine, Leiendecker et al identify a selective vulnerability of MCC for inhibitors of the lysine-specific histone demethylase 1A (LSD1). LSD1 inhibitors promote differentiation of tumor cells toward normal Merkel cell fate, impairing tumor cell growth in vivo, and opening new avenues for the treatment of patients with MCC.Solitary primary pelvic intraperitoneal hydatid cysts are rare. We report the case of a 22-year-old women who presented with a dull ache in her lower abdomen for 2 years and increased urinary frequency over 3 months. Ultrasonography and CT indicated a solitary primary peritoneal pelvic hydatid cyst. Hydatid serology was positive. Perioperative albendazole was prescribed and laparoscopic cystectomy planned. Intraoperatively, dense adhesions to the omentum, urinary bladder, and left fallopian tube were taken down laparoscopically. A small Pfannenstiel incision was made to separate the bladder's left lateral edge and deliver the cyst externally. This report details our experience of managing this case and reviews pertinent literature.
  Myocardial perfusion is evaluated in first-pass MRI using a gadolinium-based contrast agent, which limits its repeatability and restricts its use in patients with abnormal kidney function. Arterial spin labeling (ASL) is a promising technique for measuring myocardial perfusion without contrast injection. The ratio of stress to rest perfusion, termed myocardial perfusion reserve (MPR), is an indicator of the severity of stenosis in patients with coronary artery disease (CAD).
 
  To quantify perfusion increases with pharmacological vasodilation, explore MPR differences between segments with and without perfusion defects, and examine the correlations between quantitative ASL and semiquantitative first-pass measurements.
 
  Prospective.
 
  Sixteen patients with suspected CAD 10 classified as "healthy," having normal perfusion on first-pass and no enhancement on late gadolinium enhancement (LGE), and six as "nonhealthy," having hypoperfused segments including ischemic and infarcted.
 
  Flow-sensitive alternating invrements were correlated (MPR r = 0.64, P = 0.008 and perfusion rho = 0.47, P = 0.007).
 
  This study demonstrates the feasibility of ASL to detect hyperemia, the potential to differentiate segments with and without perfusion defects, and significant correlations between ASL and semiquantitative first-pass.
 
  2 TECHNICAL EFFICACY STAGE 1.
 2 TECHNICAL EFFICACY STAGE 1.Since the operation of the Three Gorges Reservoir, its tributaries have been eutrophic and flooded many times, the prompt and accurate eutrophication assessment is the foundation of water environmental management for this area. To address the problems existing in the fuzzy comprehensive evaluation, a novel method is proposed to adjust the indicator weight by using the analytic hierarchy process-entropy weight method, improve the fuzzy operation method, and take the weighted average as the basis of comprehensive evaluation. Through this method, the information of each indicator can be comprehensively used, and the subjectivity and blindness of evaluation can be effectively reduced. Then the eutrophication status of Hanfeng Lake is analyzed by it, and compares the results with that of conventional methods. The results show that Hanfeng lake is greatly affected by TN and TP, and it is generally in mesotrophic to mildly eutrophication. Eutrophication degree is as follows Nanhe River > Donghe River > Regulating dam, so the control measures should be strengthened in Nanhe area. Combined with the water pollution control measures proposed in this paper, it can provide guidance for the monitoring and treatment of eutrophication in the Three Gorges Reservoir area and ensure the safety of the water environment.  https://www.selleckchem.com/products/lotiglipron.html  PRACTITIONER POINTS This paper proposes to use the analytic hierarchy process-entropy weight method combined with the fuzzy operation method to assess the eutrophication status of tributaries of the Three Gorges Reservoir, in China. The results indicate that Hanfeng Lake is generally in a light eutrophication state, which is greatly affected by TN and TP, and the Nanhe River is in a relatively high degree of eutrophication, which need to be extra vigilant. The evaluation results are more conformable to reality than that of the traditional fuzzy comprehensive evaluation, which can provide guidance for comprehensive management of eutrophication.