https://www.selleckchem.com/products/i-191.html Significant gender and age differences in personality as well as in coping skills emerged. Girls scored higher on Harm Avoidance, Reward Dependence, Persistence and Problem Focus, and boys scored higher on Novelty Seeking and Distraction. Moreover, pre-adolescents (10-12 years) reported lower scores on Novelty Seeking and higher on Problem Focus than early adolescents (13-14 years). Overall, the results suggest that bio-psycho-social individual factors linked to personality, gender, and age have an important role in shaping pre- and early adolescents' coping and adaptation responses. Practical implications of the results and future developments are discussed.Titanium dioxide (TiO2) nanoparticles (NPs) are used extensively in a variety of commercial, industrial, and medical products, due to which human exposure is inevitable. This study aimed to explore the potential of eugenol and thymoquinone (TQ), two well-known antioxidants, in counteracting the NP-induced toxicity in human blood cells in vitro. Fresh lymphocytes and erythrocytes were isolated from volunteer human blood donors and incubated with 50 μg/mL of TiO2 NPs in the presence and absence of 50 μM of TQ and 20 μg/mL of eugenol for 3 h. Results showed that NP-treatment-induced hemolysis, oxidative stress, lactate dehydrogenase (LDH) leakage, and reduced ATPase activity in the erythrocytes. In the lymphocytes treated with NPs alone (50 μg/mL), cytotoxicity in MTT assay and DNA damage in comet assay were observed; in addition, mitochondrial membrane potential collapsed and ADP/ATP ratio increased indicating mitochondrial function impairment. However, in the presence of antioxidants, all these NP-induced changes were mitigated significantly. The results were more significant when both antioxidants eugenol and TQ were given together. Thus, it seems that antioxidants eugenol and TQ can be used as a protective agent against TiO2 NP-induced toxicity.Objectives The purp