Epidemiological evidence on cardiometabolic health of particulate organic matter (POM) and its sources is sparse. In a panel of 73 healthy adults in Beijing, China, daily concentrations of ambient fine particulate matter-bound polycyclic aromatic hydrocarbons (PAHs) and n-alkanes were measured throughout the study period, and Positive Matrix Factorization approach was used to identity PAHs sources. Linear mixed-effect models and mediation analyses were applied to examine the associations and potential interlink pathways between POM and biomarkers indicative of hemodynamics, insulin resistance, vascular calcification and immune inflammation. We found that significant alterations in cardiometabolic measures were associated with POM exposures. In specific, interquartile range increases in PAHs concentrations at prior up to 9 days were observed in association with significant elevations of 2.6-2.9% in diastolic blood pressure, 6.6-8.1% in soluble ST2, 10.5-14.5% in insulin, 40.9-45.7% in osteoprotegerin, and 36.3-48.7% in interleukin-17A. Greater associations were generally observed for PAHs originating from traffic emissions and coal burning. Mediation analyses revealed that POM exposures may prompt the genesis of hemodynamic abnormalities, possibly via worsening insulin resistance and calcification potential. These findings suggested that cardiometabolic health benefits would be achieved by reducing PM from combustion emissions.Hydrogen sulfide (H2S) is an air pollutant to cause tracheal injury.  https://www.selleckchem.com/products/ozanimod-rpc1063.html  Pyroptosis is responsible for tissue injury through reactive oxygen species (ROS) production. Competitive endogenous RNAs (ceRNAs) chelate microRNAs and reduce their inhibitory effect on other transcripts, thus affecting ROS levels and pyroptosis. However, it is not clear how H2S regulates pyroptosis via the ceRNA axis. Therefore, we established a broilers model of H2S exposure for 42 days to assess pyroptosis and obtain a ceRNA network by immunohistochemistry and RNA sequencing. We detected pyroptosis induced by H2S and verified circRNA-IGLL1-17828/miR-6631-5p/DUSP6 axis by a double luciferase reporter assay. We also measured ROS levels and the expression of pyroptotic indicators such as (Caspase1) Casp-1, Interleukin 1β (IL-1β) and Interleukin 1β (IL-18). miR-6631-5p knockdown decreased pyroptotic indicators induced by H2S. Overexpression of miR-6631-5p or DUSP6 knockdown stimulated ROS generation and upregulated pyroptotic indicators. N-acetyl-L-cysteine (NAC) decreased pyroptotic indicators and ROS levels both induced by miR-6631-5p. Moreover, circRNA-IGLL1-17828, participated in intermolecular competition as a ceRNA of DUSP6. In conclusion, circRNA-IGLL1-17828/miR-6631-5p/DUSP6 crosstalk regulated H2S-induced pyroptosis in broilers trachea via ROS generation. This is the first study to reveal regulation mechanism of circRNA-related CeRNAs on pyroptosis induced by H2S, providing important reference for environmental toxicology.Simultaneously capturing organic pollutants and heavy metal can greatly reduce the water remediation time and cost, however it is still a great challenge presently. Herein, two novel thiol/methylthio-functionalized porous aromatic frameworks were synthesized as sorbents via the Sonogashira-Hagihara reaction of 1,3,5-triethynylbenzene and 1,3,5-tris(4-bromophenyl) benzene, the subsequent chloromethylation of the phenyl rings, and the final nucleophile substitution of -Cl groups by NaSH/NaSMe. These two sorbents were characterized by FT-IR spectra, energy dispersive X-ray spectra, scanning electron microscope, nitrogen adsorption analysis, thermo-gravimetric analysis, and elemental analyses. Adsorption experiments displayed that new sorbents had high uptake abilities and fast adsorption kinetics for aromatic pollutants and mercury (II) (Hg(II)). The maximum adsorption capacity (Qmax) of toluene and m-xylene on both new sorbents were 531.9-571.4 mg/g with the kinetic binding rate constants (kobs) of 0.00276-0.02422 g/mg/min, and the Qmax values of Hg(II) were 148.1-180.3 mg/g with kobs of 0.00592-0.01573 g/mg/min. Moreover, new sorbents indicated high simultaneous uptake abilities for these pollutants with good reusability, and finally they were successfully applied to the simultaneous remediation of these pollutants in two simulated sewages with high and low concentration, indicating their great practical application potential in wastewater remediation.A novel, bio-derived cyclodextrin-based trifunctional adsorbent has been successfully synthesized for efficient, rapid and simultaneous removal of a broad-spectrum of toxic ionic (anionic and cationic dyes) and non-ionic organic pollutants from water. The composition, morphology and the presence of functional groups in the obtained sorption material were characterized by elemental analysis, XRD, SEM, and FTIR spectroscopy. The adsorption results were represented by cationic dye (crystal violet, CV) and endocrine disrupting compound (bisphenol A, BPA) as an adsorbate. The sorption processes of the model pollutants were studied with both kinetic and equilibrium models. The results showed that the sorption was rapid (less than 1 min) and the time evolution could be fitted using a pseudo-second order model. According to Langmuir isotherm model, the maximum adsorption capacities were found at 113.64 and 43.10 mg g-1 for BPA and CV, respectively. The adsorption ability of β-CDPs was kept nearly on the same level after five regeneration cycles. Furthermore, almost complete removal of the pollutants was observed during the treatment of real effluents samples thus the bio-derived, cheap and reusable BAN-EPI-CDP has a promising potential for practical applications.Phenolics are size products present in tons concentrations in industrial wastewater that can cause adverse health effects when released in the environment. As such, there is a growing interest in the development of efficient strategies for the removal of phenolic compounds from polluted water. Herein we describe the use of poly(3,4-ethylenedioxythiophene) (PEDOT)-Au/peroxidase micromotors as dynamic biocatalytic platforms for the removal of model phenolics (phenol, bisphenol A, guaiacol, pyrogallol and catechol). Micromotors are synthetized by using a simplified template electrodeposition protocol followed by covalent enzyme immobilization in the inner Au layer. Kinetic parameters revealed that enzyme immobilization in the inner micromotor layer increased over 2-fold the enzymatic activity, along with increasing operational pH and thermal stabilities. The micromotors can propel at speed of up to 60 µm/s, generating an enhanced fluid mixing that results in removal efficiencies of up to 60% as compared with the 27% removal when using free peroxidase under the same conditions.