https://www.selleckchem.com/products/grazoprevir.html Over the past century, groundwater levels in California's San Joaquin Valley have dropped more than 30 m in some areas mostly due to excessive groundwater extraction used to irrigate agricultural lands and sustain a growing population. Between 2012 and 2015 California experienced the worst drought in its recorded history, depleting surface water supplies and further exacerbating groundwater depletion in the region. Due to a lack of groundwater regulation, exact quantities of extracted groundwater in California are unknown and hard to quantify. Recent adoption of the Sustainable Groundwater Management Act has intensified efforts to identify sustainable groundwater use. However, understanding sustainable use in a highly productive agricultural system with an extremely complex surface water allocation system, variable groundwater use, and spatially extensive and diverse irrigation practices is no easy task. Using an integrated hydrologic model coupled with a land surface model we evaluated how water management activities, specifically a suite of irrigation and groundwater pumping scenarios, impact surface water-groundwater fluxes and storage components, and how those activities and the relationships between them change during drought. Results showed that groundwater pumping volume had the most significant impact on long-term water storage changes. Comparison with total water storage anomaly (TWSA) estimates from NASA's Gravity Recover and Climate Experiment (GRACE) provided some insight as to which combinations of pumping and irrigation matched the GRACE TWSA estimates, lending credibility to these scenarios. Additionally, the majority of long-term water storage changes during the recent drought occurred in groundwater storage in the deeper subsurface. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.An optimal habitat-selecting organism should