ssification we developed based on longitudinal heart rate assessment may be used in the late 2nd or early 3rd trimester to identify iCCHB cases at high risk of adverse perinatal outcome. This prognostic stratification should help refine counseling and perinatal management earlier in pregnancy instead of waiting for late gestation or predelivery assessment.
  The objective of this study is to investigate the allergen sensitization pattern among 4,203 children in the Shanxi region of China and to provide guidance for diagnosis and prevention of allergic diseases.
 
  A retrospective analysis was conducted on the allergen-specific immunoglobulin E (sIgE) results of 4,203 children aged 0-12 years from January to December in 2019. SIgE antibodies to 19 allergens in the serum sample were detected by enzyme ALLERGO-SORBENT testing.
 
  In total, 49.70% (2,089/4,203) of children with allergic diseases were positive for sIgE, and the top 5 allergens were egg white 18.63% (783/4,203), artemisia 14.47% (608/4,203), milk 13.04% (548/4,203), ragweed 8.66% (364/4,203), and poplar/willow/elm 8.52% (358/4,203). Significant differences in the positive rate of food allergens and aeroallergens in different ages were found (p < 0.05). 50.98% (1,065/2,089) patients were sensitive to 2 or more allergens. The high sensitization rate in the >3-year group was significantly higher than the ≤3-year group (p < 0.05).
 
  Egg white and artemisia are the most common allergens in children in northern China. This study provides allergic sensitization pattern of children and clinical epidemiological data in the region.
 Egg white and artemisia are the most common allergens in children in northern China. This study provides allergic sensitization pattern of children and clinical epidemiological data in the region.Cervical spondylogenic myelopathy (CSM) represents a common differential diagnosis for spinal onset Amyotrophic Lateral Sclerosis (ALS). Identifying occurrence of ALS in patients with CSM may be challenging. We evaluated the accuracy of Awaji criteria in the diagnosis of ALS in a cohort of patients with CSM. We screened all patients attending Turin ALS Center during the 2006-2018 period. We selected only patients for whom cervical cord MRI showed radiological signs of CSM. All patients underwent electromyography (EMG), and Awaji criteria were used for diagnosis of clinically probable ALS. All patients were followed up clinically for at least 6 months, and ALS diagnosis was eventually confirmed according to El-Escorial revised criteria, based on disease progression. Of 2,059 patients screened, in 42 cases, MRI showed signs of CSM; CSM incidence and prevalence risks were 0.16 and 2.04%, respectively. Based on clinical progression, 72.7% of patients were diagnosed as CSM and 27.3% as CSM + ALS. At EMG 6 (18.2%) patients fulfilled the criteria for ALS, 5 of them (83.3%) during clinical follow-up were diagnosed as clinical definite ALS + CSM. Accuracy of Awaji criteria in diagnosing ALS was good (AUC = 0.757, p = 0.03). Sensitivity and specificity of Awaji criteria were, respectively, 55.6 and 95.8%. Positive predictive value was 83.3%, while negative predictive value was 85.2%. CSM-ALS comorbidity is a relatively common problem in clinical practice. To better choose patients who could benefit from surgery, EMG should be performed in CSM patients, due to its good accuracy in recognizing ALS.The ZnCo2O4@NiCo2S4@PPy core-shell nanosheets material is prepared by directly growing leaf-like ZnCo2O4 nanosheets derived from the metal-organic framework (MOF) on Ni foam (NiF) via chemical bath deposition and annealing methods and then combining with NiCo2S4 and PPy via electrodeposition methods. The special core-shell structure formed by MOF-derived ZnCo2O4, NiCo2S4 and PPy creates a bi-interface, which could significantly promote the contact between electrode and electrolyte, provide more active sites and accelerate electron/ion transfer. And the combination of these three materials also produces a strong synergistic effect, which could further improve the capacitive performance of the electrode. Therefore, the ZnCo2O4@NiCo2S4@PPy/NiF electrode exhibits the maximum areal capacitance (3.75 F cm-2) and specific capacitance (2507.0 F g-1) at 1 mA cm-2 and 0.5 A g-1, respectively. Moreover, its capacitance retention rate is still 83.2% after 5000 cycles. In addition, a coin-type hybrid supercapacitor is assembled and displays a high energy density of 44.15 Wh kg-1 and good cycling performance.The aim of this study was to evaluate the biocompatibility and osteogenic potential of 50%Nb-xTi-Zr (NTZ, x=20%, 30%, 40% by weight) alloys as compared with dental commercial pure titanium (cpTi). Cell cytotoxity assay, fluorescence microscopy and electron microscopy were used to measure the in vitro biocompatibility of NTZ. The expression of alkaline phosphatase (ALP), integrin β1, osteocalcin (OC), Ki67 and collagen-I (Col-I) at the mRNA level was measured by real-time reverse transcription-polymerase chain reaction (RT-PCR). Osseointegration ability was determined using X-ray evaluation and histological analysis in vivo. Compared with the MG63 cells grown on cpTi on day 3, the viability, adherence and proliferation rates of cells cultured on NTZ alloys were significantly improved (p less then 0.05). Furthermore, similar expression levels of Ki67, Col-Ⅰ, OC and ALP were found in the MG63 cells grown on NTZ alloys and those grown on cpTi. The Cbf α1 level was significantly higher for the 50%Nb-30%Ti-Zr (NTZ3) than for the cpTi group on day 6 (p less then 0.01), indicating that NTZ alloys can induce osteogenesis.  https://www.selleckchem.com/products/cc-122.html  A considerable amount of new bone formation and osseointegration was observed around NTZ3 implants compared with cpTi implants in vivo. Collectively, NTZ3 showed superior biocompatibility and osteogenic activity; therefore, NTZ3 may be an excellent replacement for dental Ti implants.In this paper we investigate a magnetic racetrack consisting of a junction of three materials with different properties. Indeed, this magnetic system is composed by two distinct regions (racetracks) connected by a thin interface the first region (termed sector 1) has isotropic in-plane magnetic chirality and supports skyrmion (S) excitations while the second (sector 3) has anisotropic chirality and consequently supports antiskyrmions (A). The interface, which would be a third region (sector 2, connecting sectors 1 and 3) located in the central part of the racetrack, is an easy-axis Heisenberg ferromagnetic material. The topological structures S and A are put in motion by applying a spin-polarized current. Under certain conditions, we show that the skyrmion and the antiskyrmion created in their respective sectors are simultaneously impelled to the interface (due to the Magnus force) to apparently become a unique object (a skyrmion-antiskyrmion pair or SAP). After glued by sector 2, the skyrmion and the antiskyrmion move together (as a SAP) along the direction of the applied current.