https://www.selleckchem.com/products/fsen1.html EV extracellular vesicle; PRISM PRogramming of Intergenerational Stress Mechanisms pregnancy cohort; LSCR Life Stressor Checklist-Revised survey; NLE negative life event; CRISYS-R Crisis in Family Systems-Revised survey; KEGG Kyoto Encyclopaedia of Genes and Genomes; NYC New York City; SD standard deviation; IQR interquartile range; Cq relative cycle threshold values; PCA principal component analysis.Objective L-theanine, a non-proteinic amino acid found in tea, is known to enhance attention particularly in high doses, with no reported adverse effects. We aimed to determine whether oral administration of L-theanine acutely enhances neurophysiological measures of selective attention in a dose-dependent manner. Methods In a double-blind, placebo-controlled, counterbalanced, 4-way crossover study in a group of 27 healthy young adults, we compared the effects of 3 doses of L-theanine (100, 200 and 400 mg) with a placebo (distilled water) on latencies of amplitudes of attentive and pre-attentive cognitive event-related potentials (ERPs) recorded in an auditory stimulus discrimination task, before and 50 min after dosing. Results Compared to the placebo, 400 mg of theanine showed a significant reduction in the latency of the parietal P3b ERP component (p  less then  0.05), whereas no significant changes were observed with lower doses. A subsequent exploratory regression showed that each 100-mg increase in dose reduces the P3b latency by 4 ms (p  less then  0.05). No dose-response effect was observed in P3b amplitude, pre-attentive ERP components or reaction time. Discussion The findings indicate L-theanine can increase attentional processing of auditory information in a dose-dependent manner. The linear dose-response attentional effects we observed warrant further studies with higher doses of L-theanine. Suriname has one of the highest stillbirth rates in Latin America and the Caribbean. To facilitate data comparison of peri