This study explored the association between history of orthodontic treatment and changes in self-esteem among British adolescents.
 
  Birth cohort study.
 
  United Kingdom.
 
  Data from 2600 participants of the British Cohort Study were analysed.
 
  Participants completed the Lawrence Self-Esteem Questionnaire (LAWSEQ) at the ages of 10 and 16 years. The change in LAWSEQ score over six years was the outcome. Participants were divided into two groups according to parental reports of orthodontic treatment at the same ages. The association between history of orthodontic treatment and six-year changes in LAWSEQ score was tested in linear regression models adjusting for demographic factors (adolescents' sex and ethnicity), family socioeconomic status (parental social class and mothers' education), perceived orthodontic treatment need and baseline LAWSEQ score.
 
  According to parental reports, 8% of participants had a history of orthodontic treatment. The mean LAWSEQ score at baseline was 13.7 (95% confidence interval [CI] 13.6-13.9) and increased significantly over time by 1.7 units (95% CI 1.5-1.9). Orthodontic treatment history was positively, albeit not significantly, associated with change in LAWSEQ score (coefficient 0.08, 95% CI -0.56 to 0.72). The direction of the association reversed but remained non-significant after adjustment for all confounders (coefficient -0.19; 95% CI -0.68 to 0.30). Improvements in self-esteem were positively associated with mothers' education (coefficient 0.85; 95% CI 0.09-1.61) and negatively associated with self-esteem at baseline (coefficient -0.79; 95% CI -0.82 to -0.75).
 
  This six-year longitudinal study provided no evidence for an association between history of orthodontic treatment and changes in self-esteem during adolescence.
 This six-year longitudinal study provided no evidence for an association between history of orthodontic treatment and changes in self-esteem during adolescence.The relationship between gender and public engagement in the literature is unclear. Unlike with other factors, research has not conclusively shown whether gender affects involvement in public engagement activities and, if it does so, in what direction. This article aims to investigate this ambiguity and intends to contribute to the understanding of underlying factors. Using survey data from a large national sample of Italian academics from all disciplines (N = 5123), we find a gender gap in public engagement activities in the mass media and not in community-based activities. These results suggest a different analytical approach for investigating gender differences in public engagement.Trilobatin is a common type of flavonoids compounds derived from Lithocarpus polystachyus Rehd leaves. Previous report suggests that trilobatin was potentially involved in pro-and anticancer, antioxidative and anti-hyperglycemic activities. Here, we investigated the anticancer efficiency of trilobatin on gefitinib resistant lung cancer cells. In this study, MTT assays, EdU incorporation assays, DAPI staining, tumor sphere formation assays, immunofluorescent staining and Western blot analysis were performed to explore the functional role of trilobatin on gefitinib resistant lung cancer cells. The results showed that trilobatin inhibits proliferation of gefitinib resistant lung cancer cells. In addition, the proportions of apoptotic cells were increased along with down-regulated expression levels of Bcl-2 and mitochondrial Cytochrome C while up-regulated Bax, Cleaved Caspase-3, -9, and cytosolic Cytochrome C expression. Moreover, trilobatin decreased tumor sphere formation and expression levels of multiple stemness markers (ALDH1, CD133, Nanog, and ABCG2) in gefitinib resistant lung cancer cells. Furthermore, investigation of the mechanism indicated that trilobatin suppressed activity of NF-κB via decreasing constitutive phosphorylation of NF-κB p65 and IκB-α in gefitinib resistant lung cancer cells. All these results indicate that trilobatin induces apoptosis and attenuates stemness phenotype of gefitinib resistant lung cancer cells, involved with, or partly, the suppression of NF-κB activity.Ferritin is an important iron storage protein, which is widely existed in all forms of life.  https://www.selleckchem.com/products/Temsirolimus.html  Ferritin can regulate iron homeostasis when iron ions are lacking or enriched in the body, so as to avoid iron deficiency diseases and iron poisoning. Ferritin presents a hollow nanocage, which can store ions or other small molecular substances in the cavity. Therefore, ferritin shows its potential as a functional nanomaterial that can deliver nutrients or drugs in a targeted manner to improve bioavailability. Due to the special structure, the research on ferritin has attracted more and more attention in recent years. In this paper, the structural characteristics of ferritin were introduced, and the natural purification and prokaryotic expression methods of ferritin from different sources were described. At the same time, ferritin can bind to small molecules, so that it has the activity of small molecules, to construct a new type of ferritin. As a result, ferritin plays an important role as a nutrient substance, in targeted transport, and disease monitoring, etc. In conclusion, the yield of ferritin can be improved by means of molecular biology. Meanwhile, molecular modification can be used to make ferritin have unique activity and function, which lays a foundation for subsequent research. HighlightsThe molecular and structural properties of ferritins were clearly described.Isolation and purification technologies of ferritin were compared.Characterization, functions and molecular modifications mechanism of ferritin were reviewed.The applications of ferritin in pharmaceutical and food industry were prospected.Recent advances in developmental, molecular and cellular biology as well as biomedical technologies show a promising future for crossing the gap between biomedical basic sciences and clinical orthodontics. Orthodontic research shall utilise the advances and technologies in biomedical fields including genomics, molecular biology, bioinformatics and developmental biology. This review provides an update on the novel and promising evolutions in biomedicine and highlights their current and likely future implementation to orthodontic practice. Biotechnological opportunities in orthodontics and dentofacial orthopaedics are presented with regards to CRISPR technology, multi-omics sequencing, gene therapy, stem cells and regenerative medicine. Future orthodontic advances in terms of translational research are also discussed. Given the breadth of applications and the great number of questions that the presently available novel biomedical tools and techniques raise, their use may provide orthodontic research in the future with a great potential in understanding the aetiology of dentofacial deformities and malocclusions as well as in improving the practice of this clinical specialty.