https://www.selleckchem.com/products/etc-159.html Constipation is a common, treatable condition that can be experienced by all age groups. This article outlines the different types of constipation and explains how the condition is diagnosed. A comprehensive and person-centred assessment is fundamental to identifying constipation, and should include taking the patient's clinical history and discussing any lifestyle factors that may be causing or contributing to the condition. This article also details the pharmacological and non-pharmacological interventions that nurses can employ in the management of constipation, including providing advice on lifestyle changes and the use of laxatives. The current study aims to observe the expression of hsa_circ_0141720 in the serum of patients with acute cerebral infarction (ACI) and to explore its clinical value in the diagnosis of ACI. Eighty patients with ACI within the previous 48 hours were selected, and 30 healthy persons in the same period were selected as the control. Microarray analysis was performed to evaluate the changes of circRNA profiles, and RT-PCR was used to validate the findings. Pearson's correlation assay was performed to analyze the correlation between the level of hsa_circ_0141720 and other clinical indicators. Microarray analysis identified eight differentially expressed cirRNAs in the serum of ACI patients. RT-PCR validated that the expression of hsa_circ_0141720 in serum of ACI patients was increased the most. Hence, we mainly focused on hsa_circ_0141720 in the following study. ROC curve analysis showed that when the cutoff value for serum hsa_circ_0141720 was 2.03, the sensitivity and specificity were 89.7% and 95.6%, respectively. Further study showed that enhanced hsa_circ_0141720 expression was positively correlated with the National Institutes of Health Stroke Scale (NIHSS) scores and infarct volume of ACI patients. Moreover, upregulation of hsa_circ_0141720 was also positively correlated with increa