https://www.selleckchem.com/products/c188-9.html The outbreak of the COVID-19 in 2020 has a severe impact on all countries. This paper first studies the impact of the epidemic on the macro-economy in China, which is one of the countries with early epidemic situation, in the rapid development stage of the epidemic situation, and the specific performance in macro-economy aspects. On this basis, study the development trend and macroeconomic performance of the United States as one of the most serious countries, and the relationship between the epidemic development and macro-economy in the United States. As for the differences in epidemic control measures between China and the US, China's indicators are significant in terms of sentiment factors, but the impact of COVID-19 on the sentiment factors in the US is different. The Chinese government has not adopted unlimited easing and maintained consistent policies. At present, the economic impact of COVID-19 on the US is far greater than that of China.This study aims to develop a general framework for predicting the duration of the Turning Period (or Turning Phase) for the COVID-19 outbreak in China that started in late December 2019 from Wuhan. A new concept called the Term Structure for Turning Period (instead of Turning Point) is used for this study, and the framework, implemented into an individual SEIR (iSEIR) model, has enabled a timely prediction of the turning period when applied to Wuhan's COVID-19 epidemic, and provided the opportunity for relevant authorities to take appropriate and timely actions to successfully control the epidemic. By using the observed daily COVID-19 cases in Wuhan from January 23, 2020 to February 6 (and February 10), 2020 as inputs to the framework it allowed us to generate the trajectory of COVID-19 dynamics and to predict that the Turning Period of COVID-19 outbreak in Wuhan would arrive within one week after February 14. This prediction turned out to be timely and accurate, which has provi