Plasma EBV concentrations ≥ 4000 copies/ml were regarded as positive. RESULTS CLN-EBV concentrations ≥ 787.5 copies/ml were regarded as positive according to receiver-operating characteristic curve analysis. The AUC of the EBV (0.925) concentration in CLN metastasis was significantly larger than the AUC of MRI (0.714) (P  0.05) and 84.62% (P  less then  0.01) for EBV DNA in CLN metastasis, respectively. The sensitivity and specificity of EBV in plasma were 77.2% and 71.8%, respectively. The diagnostic specificity and AUC of EBV in CLNs were higher than those of MRI and plasma EBV (P  less then  0.005). CONCLUSIONS Ultrasound-guided CLN FNA to obtain EBV concentrations may provide a new method to diagnose CLN metastasis with high sensitivity and specificity.BACKGROUND An early diagnosis of acute coronary syndrome (ACS) is crucial for treatment and prognosis. The aim of this study was to evaluate the Manchester triage system (MTS) for patients with ACS, e.g. ST-segment elevation myocardial infarction (STEMI), non-ST elevation myocardial infarction (N-STEMI) and unstable angina pectoris (UAP). METHODS Retrospective analysis of patients diagnosed with ACS (STEMI, N‑STEMI and UAP) who were triaged in the emergency department (ED) with the MTS. RESULTS In this study 282 patients with ACS (STEMI 34.0%, N‑STEMI 61.7%, UAP 4.3%) were triaged as MTS level 1 (immediate assessment) 0.4%, MTS level 2 (very urgent) 51.4%, MTS level 3 (urgent) 41.5%, MTS level 4 (standard) 6.7%, MTS level 5 (non-urgent) 0%. We observed significantly lower mean MTS levels in males (male 2.48 ± 0.59, female 2.68 ± 0.68, p = 0.02) and in patients younger than 80 years (age less then 80 years 2.50 ± 0.61, age ≥80 years 2.70 ± 0.67, p = 0.03). We did not find a significant difference of mean MTS levels in different types of ACS (STEMI 2.46 ± 0.6, N‑STEMI 2.59 ± 0.64, STEMI vs N‑STEMI p = 0.11, UAP 2.67 ± 0.65, STEMI vs UAP p = 0.26) and with respect to diabetes (diabetic 2.47 ± 0.57, non-diabetic 2.58 ± 0.65, p = 0.13). The in-hospital mortality was 2.5% (MTS level 2 n = 3, MTS level 3 n = 3, MTS level 4 n = 1). CONCLUSION The majority of patients with ACS were classified as MTS levels 2 and 3. There was no significant difference of mean MTS levels in patients with STEMI, NSTEMI and UAP. In order to assure an early diagnosis of STEMI, an electrocardiogram (ECG) should be carried out immediately or at least within 10 min after first medical contact in the ED in all patients suspected for ACS, irrespective of the assigned MTS level.The aim of this work is to determine the effect of chronic immobilization stress on kinetics and dosimetry of 67Ga in a mouse model. A control group (CG) and a stress group (SG), each with 15 mice, were included in the study, and the latter group was subjected to a chronic immobilization stress model 2 h daily for 14 consecutive days. At day 13, 67Ga-citrate was administered intraperitoneally (11.24 ± 0.44 MBq) to each mouse. Then, sets of three mice were obtained sequentially at 24, 36, 48, 60 and 72 h, in which the radionuclide activity was measured with an activity counter. The 67Ga biokinetic data showed a fast blood clearance in the SG, with a mean residence time of 0.06 h. The calculated mean radiation absorbed doses were liver (2.45 × 10-03 Gy), heart (3.17 × 10-04 Gy) and kidney (1.88 × 10-04 Gy) in the SG. The results show that stress reduced weight gain by approximately 13% and also increased adrenal gland weight by 26%. On the other hand, chronic stress accelerates 67Ga clearance after 24 h compared to normal conditions.  https://www.selleckchem.com/products/Erlotinib-Hydrochloride.html  It is concluded that murine organisms under chronic immobilization stress have higher gallium-67 clearance rates, decreasing the cumulated activity and absorbed dose in all organs.Monte Carlo codes have been used for approximately 80 years to solve various problems in medical physics. In this paper, the importance of the MCNPX code in treatment planning is highlighted. As illustrative examples of the role of MCNPX in this field, some dosimetric parameters, isodose distribution curves, and figures of merit (FOMs) were considered for photon beams of various energies. To the best of the authors' knowledge, such a systematic study has not been done before. Tissue-air ratio values were obtained as a function of depth in tissue as well as field size. The results of the simulations were in agreement within 3.5% with experimental results reported in the literature. Backscatter factor values were calculated as a function of beam energy, and found to be in agreement with published experimental values within 5.9%. The isodose curves for different conditions and beam arrangements were also simulated. Besides, FOMs were calculated for different radiation energies. All the results were in agreement with related data in the literature. It is concluded that the MCNPX code and the models developed in the present study can be used in different conditions where these parameters are involved, improving individualized treatment planning for individual patients.The study examines the consequences of climate change in Malus (apple) and Pyrus (pear) on four phenological stages bud swelling (code 51 BBCH Monograph), budburst (code 53), beginning of flowering (code 61), and end of flowering (code 69) in the temperate-continental climate of southern Romania. The hypothesis tested is how much the onset dates (TOD) of phenology stages moved earlier due to climate change. Weather and phenological data were collected from 1969 to 2018 and were statistically processed. There was an increase in air temperature (T) during the first 5 months in the year, with a significant rise in March and April; significant linear relationships show an advance in TOD with the years elapsed. Inverse linear relationships were found between TOD, maximum (Tmax), mean (Tmean), minimum (Tmin) temperature, and sunshine hours (Sh). The relationships between TOD and Tmax were the strongest. The early stages of flowering phenology are advancing more strongly than later flowering stages. For apple, in the last 50 years, there was an advance of 13.