The aim To study the dietary peculiarities of Ukrainian adolescents with obesity and to identify the eating disorders on the background of metabolic syndrome.
 
  Materials and methods A survey on the nutrition of Ukrainian adolescents was conducted at O. Yaremenko Ukrainian Institute for Social Research within the framework of the international project Health and Behavioral Orientations of Student Youth (HBSC), 2018. As a result, a sample of 200 adolescents with obesity (age 14-18 years 100 boys and 100 girls) was formed, with the following examination by the Institute of Children and Adolescents Health Care of the National Academy of Medical Sciences of Ukraine.
 
  Results A survey conducted revealed the problem of irrational and unbalanced diet in Ukrainian adolescents. Thus, irregular and unbalanced diet naturally causes digestive disorders and contributes to the formation of comorbid pathologies such as obesity and metabolic syndrome. The general analysis of the DEBQ survey results revealed that patients with metabolic syndrome were twice as likely to have abnormalities in eating behavior (71.8 ± 3.7)% than in patients without them (39.4 ± 4.1)%, (φ < 0.05). Adolescents with obesity experienced significant zinc and magnesium deficiency in the body (φ < 0.05).
 
  Conclusions Modification of eating behaviour through healthy balanced nutrition and psychological support is one of the most important tasks in the treatment of patients with obesity and metabolic syndrome.
 Conclusions Modification of eating behaviour through healthy balanced nutrition and psychological support is one of the most important tasks in the treatment of patients with obesity and metabolic syndrome.
  The aim Of the study was to evaluate the early utility changes of the 13C methacetin breath test parameters in patients with NAFLD.
 
  Materials and methods There were included 50 subjects in the study, among them 35 patients had steatosis and 15 patients had steatohepatitis, including 35 (70.0%) male subjects and 15 (30.0%) female subjects. The control group included 17 apparently healthy volunteers, among them 10 (58.8%) subjects were male and 7 (41.2%) subjects were female.
 
  Results It was determined that metabolism kinetics in case of liver steatosis was significant decreased more than 30% compared to the control group (p = 0.0001) and in case of steatohepatitis that decrease was more than 65% (p = 0.00001) compared with normal values. It resulted in less cumulative dose accumulation in steatosis (p = 0.00001) and steatohepatitis (p = 0.00001). Among the reasons for the decrease in the kinetics of metabolism in steatosis, there were insufficient response of hepatocytes on 10 minutes (<10 dose/h,%) in 40% of cases and reduction of metabolism rate amplitude at 20-40 minutes following methacetin administration.
 
  Conclusions The results of 13C-methacetin breath test demonstrate that in patients with NAFLD there is a gradual slowing of metabolism rate in hepatocytes, which leads to a decrease in cumulative dose.
 Conclusions The results of 13C-methacetin breath test demonstrate that in patients with NAFLD there is a gradual slowing of metabolism rate in hepatocytes, which leads to a decrease in cumulative dose.
  The aim Was to evaluate the effectiveness of the use of information technology of intelligent monitoring in solving the problems of assessing the morbidity of a patient with IBD during treatment.
 
  Matherials and methods 183 patients with IBD were observed. Among them 104(56.8%) patients suffered from Crohn's disease and 79(43.1%) patients had ulcerative colitis. For each patient and each disease, the formation of a list of signs, the extraction of information and knowledge will be carried out according to an individual method. At the lower level, tasks are performed determination of the list of patient morbidity conditions, the formation of a list of indicators of the patient morbidity conditions, their identification as classes for machine learning models; formation of a list of signs, which identify the state of the patient's morbidity and whose characteristics obtained after results of medical tests.
 
  Results The number of correctly classified points reached 92%. An analysis of the conditions of patients characterized by incorrectly classified points revealed the information content of this fact.  https://www.selleckchem.com/products/Azacitidine(Vidaza).html  In those cases when the classification results did not coincide with the expert assessment of the patient's condition, additional factors were found that influenced his condition and whose characteristics were not taken into account in the structure of classifier models.
 
  Conclusions The results of the testing of classifier models indicate the effectiveness of the use of information technology of intelligent monitoring to assess the condition of patients with IBD.
 Conclusions The results of the testing of classifier models indicate the effectiveness of the use of information technology of intelligent monitoring to assess the condition of patients with IBD.
  The aim To evaluate the relationship of certain alleles of HLA class II leukocyte antigens and the profile of antibodies to various subunits of nicotinic acetylcholine receptors (nAChR), the level of Treg lymphocytes and the serum concentration of anti-inflammatory IL-10 for various clinical myasthenia gravis phenotypes.
 
  Materials and methods We examined 217 patients with thymus-independent myasthenia (n = 42) and thymus-dependent myasthenia, among them patients with thymus hyperplasia (n = 108) and thymoma (n = 67). We used the following methods ELISA, flow cytometry, light and fluorescence microscopy.
 
  Results Certain genomic (polymorphism of leukocyte HLA-DR antigens) and epigenomic (antibodies to α1 and α7 nAChR subunits, expression of Treg lymphocytes and concentration of cytokines) predictors were identified for various myasthenia phenotypes. The presence of HLA haplotypes DR2 and DR7 in some young patients with M with disease progression led to the development of myasthenia gravis with thymoma (MT) at an older age. The presence of α7 nAChR subunit on thymocyte mitochondria was revealed, which is an additional autoimmune target for autoantibodies in patients with myasthenia gravis. An increase in the concentration of cytokines (IL-4, IL-8, IFN-γ) in all patients with myasthenia gravis was revealed.
 
  Conclusions Estimate the features of the formation of various variants of the immune response in thymus-independent and thymus-dependent myasthenia gravis is a necessary condition for targeted immunocorrection or surgery.
 Conclusions Estimate the features of the formation of various variants of the immune response in thymus-independent and thymus-dependent myasthenia gravis is a necessary condition for targeted immunocorrection or surgery.