https://www.selleckchem.com/products/Nolvadex.html The particles with PDMAEMA shell showed the highest release of DOX at pH = 7.4 whereas PMAA shells displayed the least cumulative release. Inversely, the lowest cumulative release at pH = 1.2 was shown by PDMAEMA-coated carriers. Moreover, particles with spherical morphology had better drug release than cauliflower-like ones originated from smart nature of carriers. Graphene is composed of a two-dimensional (2D) layer of carbon atoms arranged in a honeycomb lattice configuration. In this paper, we adopted a green synthetic method of producing reduced graphene oxide using glucose as a reducing and stabilizing agent. We also investigated the fabrication of electrospun nanofibers of glucose-reduced graphene oxide (GRGO) (0-1.0 wt%) reinforced with polyvinyl alcohol (PVA) as (PG) scaffolds, and chemically crosslinked with acidic glutaraldehyde (GA) in acetone medium to mimic the extracellular matrix (ECM) for skin tissue engineering applications. These PG scaffolds were evaluated for morphology, mechanical strength, surface wettability, thermal properties, hemocompatibility, and biocompatibility. Field emission-scanning electron microscopy (FE-SEM) revealed an increase in the thickness of nanofibers in PG scaffolds with an increase in the concentration of GRGO. X-ray diffraction and attenuated total reflectance-infrared and Raman spectra showed the GRGO was incorporated in the PVA nanofibrous matrix. As the concentration of GRGO was increased in PG scaffolds, tensile strengths and elongations at break decreased, whereas thermal properties increased. The biological activities of PG scaffolds were evaluated using in vitro hemolysis, using CCD-986Sk (a human skin fibroblast cell line) viability and proliferation assays, and by live/dead cell imaging. Results showed GRGO inclusion in PVA nanofibers caused a slight hydrophilic to hydrophobic shift. PG scaffolds did not cause hemolysis of red blood cells even at a GRGO loadin