κ-Selenocarrageenan is made from natural κ-carrageenan, in which Se partially replaces Sulfur (S). The underlying mechanism of κ-selenocarrageenan degradation remain unreported so far. Here, we describe the complete genome of a cold seep bacterium, Bacillus sp. N1-1, which can degrade κ-selenocarrageenan. The strain has a circular genome of 4,497,340 bp and 40.48 mol% G + C content, consisting of 4272 protein-coding sequences (CDSs), 87 tRNAs, as well as 28 rRNA operons as 5S-16S-23S rRNA. N1-1 genome contains several protein-coding genes relating to polysaccharide degradation and the potential of this bacterium to produce enzymes for the hydrolysis of κ-selenocarrageenan on the basis of complete genome analysis could be discovered. V.'Relapse prevention' has become a familiar concept and practice for those engaged with drug treatment services. The ways that 'relapse prevention' is currently practised and talked about departs primarily from research produced within the discipline of psychology, and especially by researchers and practitioners adopting cognitive behavioural (Marlatt and Donovan, 2005;Witkiewitz and Marlatt, 2009)and neurocognitive approaches (Tapert et al., 2004). The outcome has been the production of 'tools' and 'mechanisms', put in place to 'prevent' people from relapsing. This way of thinking about relapse has generated the assumption that once access to these 'tools' has been granted, relapse becomes a problem of the individual, a personal 'success' or 'failure', depending on how these tools are used, a measurement of how much one 'really' wants to recover. This system of thought reproduces longstanding discourses of blame against AOD users and fuels the discussion on the 'revolving doors' of recovery (White and Kelly, 2010), holding treatment services accountable for 'failing' to produce and maintain 'recovered' bodies. In this paper my aim is to challenge the production of relapse as a 'threat' and to rethink it as a desire to connect, a desire that can be either enhanced, or broken. Drawing on empirical data produced in two recovery services, one in Liverpool (UK) and one in Athens (Greece), analysed through a Deleuzo-Guattarian system of thought, I discuss relapse in two different ways(a) as part of the temporality of recovery, a way to start building connections with services; as the expression of an emerging desire under exploration, and(b) as the consequence of broken and interrupted connections when policy fails to support the encounters emerging in the recovery space, disrupting thus the recovery process. Crown V. All rights reserved.BACKGROUND Bariatric surgery is an effective treatment for adults affected by obesity.  https://www.selleckchem.com/products/nvp-bgt226.html  Demand is greater than supply and a prioritization system for patients is needed. OBJECTIVE Clinical practice guidelines recommends bariatric surgery as a management strategy for adults with severe obesity (body mass index ≥40 or 35-40 kg/m2 with co-morbidities). Eligible patient's access surgery on a first-come-first-serve basis and wait times can be several years. This study quantifies patient preferences toward attributes that could be evaluated when prioritizing patients for surgery. SETTING A Canada-wide study of adults living with obesity. METHODS A discrete choice experiment was conducted via email with a sample of Canadian adults with obesity. Six relevant attributes were identified through focus groups. Respondents completed 12 choice tasks and demographic and weight loss-related questions. A multinomial logit model was used to estimate preference weights of each attribute. RESULTS A total of 515 individuals completed the survey. Fifty-nine percent were female, 97% made previous weight loss attempts, and 5% had bariatric surgery. On average patients prioritized individuals with significant problems with daily activities versus none (odds ratio [OR] 4.41; 95% confidence interval [CI] 4.31-4.52); 3 existing cardiovascular co-morbidities versus 0 (OR 4.24; 95%CI 4.12-4.36); extreme impact on mental health versus no impact (OR 3.73; 95%CI 3.64-3.84); 6 other co-morbidities versus 0 (OR 3.43; 95%CI 3.31-3.55); waiting 5 versus 1 year (OR 1.59; 95%CI 1.46-1.68); and a body mass index of 60 versus 40 (OR 1.52; 95%CI 1.43-.62). CONCLUSION All 6 attributes were important to patients in the prioritization for bariatric surgery. However, the number of cardiovascular co-morbidities and the impact on daily activities were considered most important. BACKGROUND nursing home-acquired pneumonia (NHAP), is among the main causes of hospitalization and mortality of frail elderly patients. Aim of this study was analysis of patients residing in long-term care facilities (LTCF) and developing pneumonia to reach a better knowledge of criteria for hospitalization and outcomes. MATERIALS/METHODS this is a prospective, observational study in which patients residing in 3 LTCFs (metropolitan area of Rome, Italy) and developing pneumonia, hospitalized or treated in LTCF, were recruited and followed up from January 2017 to June 2019. Primary endpoint was 30-day mortality, secondary endpoint was analysis of risk factors associated with hospitalization. RESULTS Overall, 146 episodes of NHAP were enrolled in the study 57 patients were treated in LTCF, while 89 patients were hospitalized. Overall incidence rates of NHAP varied from 2.6 to 7.5 per 1000 residents. Methicillin-resistant Staphylococcus aureus was the most frequently isolated pathogen (25%), and in 28 (55%) patients was documented a MDR pathogen. For hospitalized patients was reported a higher 30-day mortality (43.8% Vs 7%, p  less then  0.001). Multivariate analysis showed that severe pneumonia, neoplasm, chronic hepatitis, antibiotic monotherapy, and malnutrition were independent risk factors for hospitalization from LTCF. MDR pathogen, severe pneumonia, COPD, and moderate to severe renal disease were independently associated with death at 30 days. CONCLUSION frail elderly patients in LTCF have a high risk of MDR etiology with a higher risk to receive an inadequate antibiotic therapy and a fatal outcome. These results point to the need for increased provision of acute care and strategies in LTCF.