Our data reinforce the importance of zebrafish as an accurate investigative toxicology model to assess acute toxicity as well as cardiotoxicity and neurotoxicity of molecules in the preclinical phase of development.Pyrethrins and their synthetic derivatives known as pyrethroids are highly effective insecticides used worldwide in the agricultural fields and households. Cypermethrin is a type II pyrethroid which acts primarily by delaying the closure of voltage-sensitive sodium channels at higher concentrations. Its toxicity in humans occur due to accidental or intentional exposure through inhalation, skin contact or via ingestion. Acute oral intoxication of cypermethrin commonly manifests with neurotoxic and gastrointestinal effects in humans. Cardiotoxic effects following ingestion of this compound have occurred in a few cases but underreported to date. This case highlights a case of intentional cypermethrin poisoning with acute effects in the form of prolonged bradycardia symptomatically managed with a muscarinic antagonist like atropine sulphate.[This corrects the article DOI 10.1016/j.jcte.2018.12.006.][This corrects the article DOI 10.1016/j.jcte.2019.100196.][This corrects the article DOI 10.1016/j.jcte.2018.11.004.][This corrects the article DOI 10.1016/j.jcte.2019.100190.][This corrects the article DOI 10.1016/j.jcte.2019.100214.][This corrects the article DOI 10.1016/j.jcte.2018.02.001.].[This corrects the article DOI 10.1016/j.jcte.2018.12.008.][This corrects the article DOI 10.1016/j.jcte.2018.03.002.][This corrects the article DOI 10.1016/j.jcte.2018.06.001.][This corrects the article DOI 10.1016/j.jcte.2020.100224.][This corrects the article DOI 10.1016/j.jcte.2019.100187.][This corrects the article DOI 10.1016/j.jcte.2019.100202.][This corrects the article DOI 10.1016/j.jcte.2019.100195.][This corrects the article DOI 10.1016/j.jcte.2020.100222.][This corrects the article DOI 10.1016/j.jcte.2020.100230.][This corrects the article DOI 10.1016/j.jcte.2018.09.001.].Renal myopericytoma is an extremely rare entity with just 11 cases reported in the literature. We report the case of a 57 year old Caucasian man who was found to have a renal myopericytoma following nephrectomy for suspected renal cell carcinoma. Renal myopericytoma has a distinct morphological overlap with other pericytic tumours and significant histological variation has been noted between cases reported to date. Further characterising this novel tumour is vital to identify subtypes within this spectrum, understand its behaviour and to identify imaging trends which may lead to pre-operative diagnosis in order to potentially avoid radical treatment.Testicular cancer is the most common form of cancer in young men aged 15-35 years and renal cell carcinoma accounts for 3% of all adult malignancy but a synchronous presentation is rare, especially a metastatic classical pattern seminoma with no testicular involvement. We report a case of metastatic seminoma in para-aortic lymph nodes after open radical nephrectomy and retroperitoneal lymph node dissection for a large left clear cell RCC. This case highlights the atypical presentation of testicular cancer, the consideration of a non-RCC associated lymphadenopathy and the importance of lymph node dissection as a treatment option for RCC-associated nodal disease.Renal ectopia with stone is a rare case with no specific reported incidence rate. The treatment of kidney stone in ectopic kidneys poses a challenge to urologists. A 48-year-old male presenting with colicky pain on the right flank since one year ago. CT urography revealed an right-crossed renal ectopia and hyperdense lesions (25 × 20 mm and 10 × 10 mm) in the ureteropelvic junction of the right kidney. Under general anesthesia, we performed open pyelolithotomy for the patient and removed two stones completely. Open surgery could be the choice for patients with complex stone burden and associated renal anomalies such as ectopic kidney.Biliary fistulas are most commonly caused by cholelithiasis. Other causes include malignancies and peptic ulcer disease. A biliary fistula caused by a penetrating trauma is a rare entity, and a post-traumatic biliary fistula to the renal collecting system is extremely uncommon.  https://www.selleckchem.com/products/wnt-c59-c59.html  We present an extremely rare case of a post-traumatic nephrobiliary fistula incurred after penetrating trauma that was successfully treated with endoscopic retrograde cholangiopancreatography (ERCP), biliary stents, and percutaneous drainage.
  We describe two adult brothers with lower limb neuropathy and one with progressive optic neuropathy. One brother was found to have profound biotinidase deficiency by identifying biallelic pathogenic variants of the 
  gene by whole exome sequencing, which was confirmed by markedly decreased serum biotinidase activity.
 
  The first brother had progressive optic atrophy and vision loss over 10years and progressive peripheral neuropathy with weakness, pain, and fatigue for 20years. Profound biotinidase deficiency was also identified in an older brother, who exhibited peripheral neuropathy since four years of age, but had no vision loss.
 
  The first brother's vision loss and neuropathy improved markedly with biotin in six months. However, the neuropathy of the other brother did not improve with 16months of biotin therapy.
 
  The first brother's neurological issues partially reversed with biotin. However, the longer-term symptoms of the other brother were irreversible. These cases emphasize the importance of considering biotinidase deficiency in the differential diagnosis of adolescents and adults with peripheral neuropathy with or without optic neuropathy/atrophy before symptoms become irreversible. Although WES initially identified the disorder in this family, measuring serum biotinidase activity was a necessary confirmatory step after WES and is less expensive than performing whole exome sequencing.
 The first brother's neurological issues partially reversed with biotin. However, the longer-term symptoms of the other brother were irreversible. These cases emphasize the importance of considering biotinidase deficiency in the differential diagnosis of adolescents and adults with peripheral neuropathy with or without optic neuropathy/atrophy before symptoms become irreversible. Although WES initially identified the disorder in this family, measuring serum biotinidase activity was a necessary confirmatory step after WES and is less expensive than performing whole exome sequencing.