It is known that, in ancient Mexico, diseases of the respiratory system were a major cause of death in the population. Severe epidemics in the XVI Century ravaged and killed nine out of ten indigenous persons. Pre-Hispanic physicians served as medical sorcerers and dealt with the physical and spiritual diseases that afflicted the population. Important medical knowledge pertaining to each culture has been identified; this knowledge explained the diseases depending on the religious beliefs of each culture, and it tried to solve the health problems that afflicted the population at that time.
  Autoimmune encephalitis occurs as a subacute condition with a strong infectious association in children. In the last 20 years, the frequency of non-infectious cases has increased significantly.
 
  A previously healthy eight-year-old male child with normal neurodevelopment, without a history of consanguinity, manifested progressive neurological deterioration with autoimmune encephalitis-limbic encephalitis up to hypothalamic dysfunction.
 
  In the mentioned case, it was documented that an inborn error of the immune system generated a severe neurological clinical picture, with permanent and irreversible damage, secondary to lack of immunological memory in the broad clinical context of a common variable immunodeficiency.
 In the mentioned case, it was documented that an inborn error of the immune system generated a severe neurological clinical picture, with permanent and irreversible damage, secondary to lack of immunological memory in the broad clinical context of a common variable immunodeficiency.
  In recent years, there have been reports of contact dermatitis due to the beta-blockers that are used in the treatment of glaucoma, such as timolol, levubonolol, carteolol, or betaxolol.
 
  A 37-year-old male patient, who was diagnosed with bilateral primary open-angle glaucoma two years ago, was in therapy with dorzolamide and a topical β-adrenergic blocker (timolol) in drops twice a day. Months later, he reported conjunctival hyperemia, stinging, and inflammation of both eyelids, followed by erythematous dermatitis, which improved upon treatment discontinuation. The patch test came back negative, but the conjunctival provocation test came back positive 48 hours later.
 
  Sensitization to the ophthalmic drops that are used to control glaucoma proved to be the mechanism that was causing the clinical picture of the patient. Performing a tolerance test for active anti-glaucoma agents may be helpful in improving tolerance to the medical treatment of some patients, thus, avoiding laser procedures and/or precipitated antiglaucomatous surgeries.
 Sensitization to the ophthalmic drops that are used to control glaucoma proved to be the mechanism that was causing the clinical picture of the patient. Performing a tolerance test for active anti-glaucoma agents may be helpful in improving tolerance to the medical treatment of some patients, thus, avoiding laser procedures and/or precipitated antiglaucomatous surgeries.
  Asthma has a global prevalence of 18%. In work-related asthma, there is an association between asthma and the exposure to dust, vapors, or fumes only at the workplace, in patients with or without a previous asthma diagnosis; it represents approximately 5-25% of the cases of adult onset asthma. In Mexico, the information about this topic is scarce.
 
  A series of 17 patients with an asthma diagnosis and occupational exposure to dust, vapors, or fumes is reported; occupational asthma was determined by the Allergy and Clinical Immunology Service at Centro Médico Nacional Siglo XXI.
 
  Occupational health is essential for the proper performance of the staff, the optimal performance of the work unit, and for avoiding health damages, economic losses, and social implications. The role of the physician in charge of occupational health in terms of prevention, diagnosis, and timely management of frequent pathologies according to the work sector, represents a great area of opportunity that is important to fulfill in many work centers.
 Occupational health is essential for the proper performance of the staff, the optimal performance of the work unit, and for avoiding health damages, economic losses, and social implications. The role of the physician in charge of occupational health in terms of prevention, diagnosis, and timely management of frequent pathologies according to the work sector, represents a great area of opportunity that is important to fulfill in many work centers.In general, diagnostic tests are the necessary tools to determine the presence or absence of illness, but they can be useful also for excluding other differential conditions, assessing severity, establishing specific treatments, and estimating possible prognosis results.  https://www.selleckchem.com/products/beta-aminopropionitrile.html  In order to determine how much a new diagnostic test can contribute in the clinical setting, studies with different research designs and populations are required. Since it might be complex to understand the development process of a diagnostic test based on its initial stages, this article synthesizes and gives examples of the four phases that have been proposed to define this process. The goals of these four phases are phase I, establishing reference values; phase II, analyzing the validity of the test; phase III, the impact of its incorporation in diagnostic-therapeutic plans; and phase IV, a long-term assessment after incorporating the diagnostic test.In 2017, the Pediatric Hospital of Sinaloa (PHS) began its affiliation to the registry of patients with primary immunodeficiency or inborn errors of immunity (IEI) on the platform of the Latin American Society for Immunodeficiencies (LASID). During this period, twelve cases with IEI have been diagnosed and treated at the hospital. The age category at the time of diagnosis varied from two days to sixteen years old, and the range of the onset of the symptoms varied from nineteen days to four years, with a predominance of males (67%). The most frequent IEI was predominantly antibody deficiency (33.3%), followed by defects in the number or function of phagocytes (16.6%), autoinflammatory disorders (16.6%), immunodeficiencies that affect cellular and humoral immunity (16.6%), combined immunodeficiencies associated with syndromic findings (8.3%), and defects in intrinsic and inborn immunity (8.3%). 84% of patients received intravenous immunoglobulin and, in one case of a patient with Wiskott-Aldrich syndrome, a pathogenic variant in the WAS gene was identified; a patient received hematopoietic stem cell transplantation, 33.