Meanwhile, we also design a novel rank loss and jointly use it with the Dice loss in segmentation networks to address the issues caused by class imbalance and hard-easy pixel imbalance. We evaluate the proposed MB-DCNN model on the ISIC-2017 and PH2 datasets, and achieve a Jaccard index of 80.4% and 89.4% in skin lesion segmentation and an average AUC of 93.8% and 97.7% in skin lesion classification, which are superior to the performance of representative state-of-the-art skin lesion segmentation and classification methods. Our results suggest that it is possible to boost the performance of skin lesion segmentation and classification simultaneously via training a unified model to perform both tasks in a mutual bootstrapping way.Recent advances in positron emission tomography (PET) have allowed to perform brain scans of freely moving animals by using rigid motion correction. One of the current challenges in these scans is that, due to the PET scanner spatially variant point spread function (SVPSF), motion corrected images have a motion dependent blurring since animals can move throughout the entire field of view (FOV). We developed a method to calculate the image-based resolution kernels of the motion dependent and spatially variant PSF (MD-SVPSF) to correct the loss of spatial resolution in motion corrected reconstructions. The resolution kernels are calculated for each voxel by sampling and averaging the SVPSF at all positions in the scanner FOV where the moving object was measured. In resolution phantom scans, the use of the MD-SVPSF resolution model improved the spatial resolution in motion corrected reconstructions and corrected the image deformation caused by the parallax effect consistently for all motion patterns, outperforming the use of a motion independent SVPSF or Gaussian kernels. Compared to motion correction in which the SVPSF is applied independently for every pose, our method performed similarly, but with more than two orders of magnitude faster computation time. Importantly, in scans of freely moving mice, brain regional quantification in motion-free and motion corrected images was better correlated when using the MD-SVPSF in comparison with motion independent SVPSF and a Gaussian kernel. The method developed here allows to obtain consistent spatial resolution and quantification in motion corrected images, independently of the motion pattern of the subject.Public understanding of contemporary scientific issues is critical for the future of society. Public spaces, such as science centers, can impact the communication of science by providing active knowledge-building experiences of scientific phenomena. In contributing to this vision, we have previously developed an interactive visualization as part of a public exhibition about nano. We reflect on how the immersive design and features of the exhibit contribute as a tool for science communication in light of the emerging paradigm of exploranation, and offer some forward-looking perspectives about what this notion has to offer the domain.Learning an expressive representation from multi-view data is a key step in various real-world applications. In this paper, we propose a Semi-supervised Multi-view Deep Discriminant Representation Learning (SMDDRL) approach. Unlike existing joint or alignment multi-view representation learning methods that cannot simultaneously utilize the consensus and complementary properties of multi-view data to learn inter-view shared and intra-view specific representations, SMDDRL comprehensively exploits the consensus and complementary properties as well as learns both shared and specific representations by employing the shared and specific representation learning network. Unlike existing shared and specific multi-view representation learning methods that ignore the redundancy problem in representation learning, SMDDRL incorporates the orthogonality and adversarial similarity constraints to reduce the redundancy of learned representations.  https://www.selleckchem.com/products/vardenafil.html  Moreover, to exploit the information contained in unlabeled data, we design a semi-supervised learning framework by combining deep metric learning and density clustering. Experimental results on three typical multi-view learning tasks, i.e., webpage classification, image classification, and document classification demonstrate the effectiveness of the proposed approach.Smart homes equipped with anonymous binary sensors offer a low-cost, unobtrusive solution that powers activity-aware applications such as building automation, health monitoring, behavioral intervention and home security. However, when there are multiple residents living in the smart home, the data association between sensor events and residents can pose a major challenge. Previous approaches to multi-resident tracking in smart homes rely on extra information, such as sensor layout, floor plan and annotated data, which may not be available or inconvenient to obtain in practice. To address those challenges in real-life deployment, we introduce the sMRT algorithm that simultaneously tracks the location of each resident and estimates the number of residents in the smart home, without relying on ground-truth annotated sensor data or other additional information. We evaluate the performance of our approach using two smart home datasets recorded in real-life settings and compare sMRT with two other methods that rely on sensor layout and ground truth-labeled sensor data.OBJECTIVE The ability to measure event-related potentials (ERPs) as practical, portable brain vital signs is limited by the physical locations of electrodes. Standard electrode locations embedded within the hair result in challenges to obtaining quality signals in a rapid manner. Moreover, these sites require electrode gel, which can be inconvenient. As electrical activity in the brain is spatially volume distributed, it should be possible to predict ERPs from distant sensor locations at easily accessible mastoid and forehead scalp regions. METHODS An artificial neural network was trained on ERP signals recorded from below hairline electrode locations (Tp9, Tp10, Af7, Af8 referenced to Fp1, Fp2) to predict signals recorded at the ideal Cz location. RESULTS The model resulted in mean improvements in intraclass correlation coefficient relative to control for all stimulus types (Standard Tones = +9.74%, Deviant Tones = +3.23%, Congruent Words = +15.25%, Incongruent Words = +25.43%) and decreases in RMS Error (Standard Tones = - 26.