These interactions, together with Notch1 and Jagged1 ectodomain dimensions and flexibility, determined by small-angle X-ray scattering, support the formation of nonlinear architectures. Combined, the data suggest that critical Notch1 and Jagged1 regions are not distal but engage directly to control Notch1 signaling, thereby redefining the Notch1-Jagged1 activation mechanism and indicating routes for therapeutic applications.Individuals with depression are prone to maladaptive patterns of thinking, known as cognitive distortions, whereby they think about themselves, the world, and the future in overly negative and inaccurate ways. These distortions are associated with marked changes in an individual's mood, behavior, and language. We hypothesize that societies can undergo similar changes in their collective psychology that are reflected in historical records of language use. Here, we investigate the prevalence of textual markers of cognitive distortions in over 14 million books for the past 125 y and observe a surge of their prevalence since the 1980s, to levels exceeding those of the Great Depression and both World Wars. This pattern does not seem to be driven by changes in word meaning, publishing and writing standards, or the Google Books sample. Our results suggest a recent societal shift toward language associated with cognitive distortions and internalizing disorders.Teleost fishes comprise one-half of all vertebrate species and possess a duplicated genome. This whole-genome duplication (WGD) occurred on the teleost stem lineage in an ancient common ancestor of all living teleosts and is hypothesized as a trigger of their exceptional evolutionary radiation. Genomic and phylogenetic data indicate that WGD occurred in the Mesozoic after the divergence of teleosts from their closest living relatives but before the origin of the extant teleost groups. However, these approaches cannot pinpoint WGD among the many extinct groups that populate this 50- to 100-million-y lineage, preventing tests of the evolutionary effects of WGD. We infer patterns of genome size evolution in fossil stem-group teleosts using high-resolution synchrotron X-ray tomography to measure the bone cell volumes, which correlate with genome size in living species. Our findings indicate that WGD occurred very early on the teleost stem lineage and that all extinct stem-group teleosts known so far possessed duplicated genomes. WGD therefore predates both the origin of proposed key innovations of the teleost skeleton and the onset of substantial morphological diversification in the clade. Moreover, the early occurrence of WGD allowed considerable time for postduplication reorganization prior to the origin of the teleost crown group. This suggests at most an indirect link between WGD and evolutionary success, with broad implications for the relationship between genomic architecture and large-scale evolutionary patterns in the vertebrate Tree of Life.Long-lived quasi-stationary states (QSSs) are a signature characteristic of long-range interacting systems both in the classical and in the quantum realms. Often, they emerge after a sudden quench of the Hamiltonian internal parameters and present a macroscopic lifetime, which increases with the system size. Despite their ubiquity, the fundamental mechanism at their root remains unknown. Here, we show that the spectrum of systems with power-law decaying couplings remains discrete up to the thermodynamic limit. As a consequence, several traditional results on the chaotic nature of the spectrum in many-body quantum systems are not satisfied in the presence of long-range interactions. In particular, the existence of QSSs may be traced back to the finiteness of Poincaré recurrence times. This picture justifies and extends known results on the anomalous magnetization dynamics in the quantum Ising model with power-law decaying couplings. The comparison between the discrete spectrum of long-range systems and more conventional examples of pure point spectra in the disordered case is also discussed.Fault friction is central to understanding earthquakes, yet laboratory rock mechanics experiments are restricted to, at most, meter scale. Questions thus remain as to the applicability of measured frictional properties to faulting in situ. In particular, the slip-weakening distance [Formula see text] strongly influences precursory slip during earthquake nucleation, but scales with fault roughness and is challenging to extrapolate to nature. The 2018 eruption of K̄ılauea volcano, Hawaii, caused 62 repeatable collapse events in which the summit caldera dropped several meters, accompanied by [Formula see text] 4.7 to 5.4 very long period (VLP) earthquakes. Collapses were exceptionally well recorded by global positioning system (GPS) and tilt instruments and represent unique natural kilometer-scale friction experiments. We model a piston collapsing into a magma reservoir. Pressure at the piston base and shear stress on its margin, governed by rate and state friction, balance its weight. Downward motion of the piston compresses the underlying magma, driving flow to the eruption. Monte Carlo estimation of unknowns validates laboratory friction parameters at the kilometer scale, including the magnitude of steady-state velocity weakening. The absence of accelerating precollapse deformation constrains [Formula see text] to be [Formula see text] mm, potentially much less. These results support the use of laboratory friction laws and parameters for modeling earthquakes. We identify initial conditions and material and magma-system parameters that lead to episodic caldera collapse, revealing that small differences in eruptive vent elevation can lead to major differences in eruption volume and duration. Most historical basaltic caldera collapses were, at least partly, episodic, implying that the conditions for stick-slip derived here are commonly met in nature.Information about dangers can spread effectively by observation of others' threat responses.  https://www.selleckchem.com/products/pf-04620110.html  Yet, it is unclear if such observational threat information interacts with associative memories that are shaped by the individual's direct, firsthand experiences. Here, we show in humans and rats that the mere observation of a conspecific's threat reactions reinstates previously learned and extinguished threat responses in the observer. In two experiments, human participants displayed elevated physiological responses to threat-conditioned cues after observational reinstatement in a context-specific manner. The elevation of physiological responses (arousal) was further specific to the context that was observed as dangerous. An analogous experiment in rats provided converging results by demonstrating reinstatement of defensive behavior after observing another rat's threat reactions. Taken together, our findings provide cross-species evidence that observation of others' threat reactions can recover associations previously shaped by direct, firsthand aversive experiences.