To compare the risk of hospitalization for adult Medicaid beneficiaries with bipolar I disorder treated with lurasidone vs. other oral atypical antipsychotics (AAPs) as monotherapy.
 
  A retrospective cohort study of the IBM MarketScan Multi-State Medicaid Claims database identified adults with bipolar I disorder who initiated an AAP (index date) between 1 January 2014 and 30 June 2019. Patients were continuously enrolled 12 months pre- and 24 months post-index date. Each month during the post-index period was categorized as monotherapy with lurasidone, aripiprazole, olanzapine, quetiapine or risperidone, no/minimal treatment, or other. Marginal structural models were performed to estimate hospitalization risk and length of stay (LOS) (all-cause and bipolar I disorder-related) compared to lurasidone.
 
  The analysis included 8262 adults. Compared to lurasidone, the adjusted odds ratios (aORs) of all-cause hospitalization were significantly higher for olanzapine (aOR = 1.60, 95% CI = 1.09-2.10) and quetiapine ization than quetiapine and risperidone. Bipolar I disorder-related hospital LOS was significantly shorter for patients treated with lurasidone compared to quetiapine.Health benefits have been attributed to the consumption of watermelon (Citrullus lanatus L.) seeds in sub-Saharan Africa and Asia but the potential toxicity especially on chronic use remains to be investigated. Here, diets containing watermelon seeds (WMSs) at 2.5% or 5% were eaten ad libitum daily for 21 d by male and female Wistar rats. Changes in body and organ (liver, kidney, brain, testis, and ovary) weights following diet supplementation were monitored. Biomarkers of organ injury, such as alanine aminotransferase (ALT), alkaline phosphatase (ALP), cholesterol (CHO), triglyceride (TRI), urea, and creatinine (CRE) were measured. WMS-formulated diet led to a decrease in body weight in male but not in female rats compared to the control group.  https://www.selleckchem.com/products/bay80-6946.html  Also, testes weight significantly increased, whereas a decrease in that of the ovaries was noted. Although the ingestion of WMS did not significantly alter the weights of the liver and brain, a trend toward reduction was noticed. No significant changes were observed for the serum levels of ALT, ALP, CHO, and TRI in all rats. However, the kidney may be targeted for toxicity as indicated by significant elevations in serum urea and CRE levels in male and female rats when compared to controls. Furthermore, the sperm morphology anomalies observed after WMS supplementation demonstrate the potentially detrimental effects of high consumption of the seeds on the male reproductive system. We conclude that WMSs at 2.5% or 5% dose in the diet may elicit negative effects in organs particularly on the kidney and testes in rats.The goals of this study were to assess retention on antiretroviral therapy (ART) and to identify predictors of loss to follow-up (LTFU) among people living with HIV (PLHIV) in Senegal. HIV-positive individuals presenting for initiation of ART in Dakar and Ziguinchor were enrolled and followed for 12 months. Data were collected using interviews, clinical evaluations, laboratory analyses, chart review, and active patient tracing. Of the 207 individuals enrolled, 70% were female, 32% had no formal education, and 28% were severely food insecure. At the end of the follow-up period, 58% were retained on ART, 15% were deceased, 4% had transferred care, 5% had migrated, and 16% were lost to follow-up. Enrollment in Ziguinchor (OR 2.71 [1.01-7.22]) and severe food insecurity (OR 2.55 [1.09-5.96]) were predictive of LTFU. Sex, age, CD4 count, BMI less then 18.5, country of birth, marital status, number of children, household size, education, consultation with traditional healers, transportation time, and transportation cost were not associated with LTFU. The strongest predictor of severe food insecurity was lack of formal education (OR 2.75 [1.30-5.80]). Addressing the upstream drivers of food insecurity and implementing strategies to enhance food security for PLHIV may be effective approaches to reduce LTFU and strengthen the HIV care cascade in the region.The essential oils (EOs) of six Hypenia species that are endemic in the central Brazilian Cerrado were assessed by GC/MS and chemometric analysis. EO variations according to two taxonomic sections, combined with two phenophases (vegetative and reproductive), showed that 23.2% of total variance was explained by such predictors. Variation partitioning showed that the largest pure contribution was attributed to section (43.7%), followed by phenophase (39.3%), with 17% of joint influence. A multivariate regression tree (MRT) indicated that 13 EO constituents may be potential chemomarkers for distinguishing sections and two developmental stages in the genus.Literature suggests that federal funding allocation for HIV-related research in the US may not align with HIV disease burden but is influenced by structural disparities. This study sought to examine how federal funding allocation is associated with HIV disease burden and research capacity of states by applying Big Data integration, text mining, and statistics. Using text mining, we identified 20,678 HIV-related federal projects from 2008 to 2018 in NIH ExPORTER, which were then integrated with data from AtlasPlus and US Census Bureau. We developed Gini coefficients to assess the inequality of funding and the Generalized Estimating Equations model to examine the associations between funding allocation and (1) state HIV disease burden, (2) state research capacity, and (3) geographic regions, respectively. The Gini coefficients (0.60 to 0.80) suggest a highly skewed funding distribution. Funding allocation was not associated with state HIV disease burden (p = 0.269) but HIV research capacity (p = 0.000). The South (with the heaviest HIV disease burden) did not receive significantly more federal funding. Our findings for the first time identified disparities of federal funding allocation, suggesting that federal agencies favor states of high research capacity over heavy disease burden, which may reinforce the HIV-related health disparities.