Cornerstones of project success included project planning, open communication, institutional buy-in, piloting the implementation, implementing custom solutions to address specific problems, data quality improvement, and data governance, unique aspects of which are featured here. We describe our experience in selecting, configuring, and loading molecular data into the molecular data warehouse. Specifically, we developed solutions for heterogeneous genomic sequencing cohorts (many different platforms) and integration with our existing clinical data warehouse.
 
  The implementation was ultimately successful despite challenges encountered, many of which can be generalized to other research cancer centers.
 The implementation was ultimately successful despite challenges encountered, many of which can be generalized to other research cancer centers.Purpose The purpose of this study was to evaluate the readability and suitability of Spanish-language hearing aid user guides. Method Hearing aid user guides in English and Spanish were downloaded for analysis. Readability for the English guides was calculated using the Flesch Reading Ease Scale and the Flesch-Kincaid Readability Formula, and readability for the Spanish guides was calculated using the Fernandez-Huerta and Spaulding Formula and Fry Graph. The Suitability Assessment of Materials was used to rate the suitability of each Spanish and English pair of hearing aid user guides. Results Of the nine manufacturers that had materials available in English, only five had guides available in Spanish. Although readability for the Spanish and English user guides was similar, both guides were written, on average, at the eighth grade level. Suitability for the analyzed Spanish and English user guides was 78% and 80%, respectively. Conclusions Spanish-language hearing aid user guides were lacking in readability and suitability. Given that patients with limited proficiency in English, including the Hispanic population, are at risk for low health literacy, providers and manufacturers are encouraged to create more Spanish-language materials. User guides in both languages would benefit from revisions to improve readability and suitability. Supplemental Material https//doi.org/10.23641/asha.14569497.The Current Insights feature is designed to introduce life science educators and researchers to current articles of interest in other social science and education journals. In this installment, I highlight three that explore how different types of stress can produce different educational outcomes, how studying by writing questions can improve performance, and how faculty beliefs about intelligence can influence students' interest in and evaluation of a course.A regioselective radical C-H trifluoromethylation of aromatic compounds was developed using cyclodextrins (CDs) as additives. The C-H trifluoromethylation proceeded with high regioselectivity to afford the product in good yield, even on the gram scale. In the presence of CDs, some substrates underwent a single trifluoromethylation selectively, whereas mixtures of single- and double-trifluoromethylated products were formed in the absence of the CD. 1H NMR experiments indicated that the regioselectivity was controlled by the inclusion of a substrate inside the CD cavity.A new synthetic approach has recently been developed for the fabrication of freestanding crystalline perovskite oxide nanomembranes, which involves the epitaxial growth of a water-soluble sacrificial layer. By utilizing an ultrathin capping layer of SrTiO3, here we show that this sacrificial layer, as grown by pulsed laser deposition, can be stabilized in air and therefore be used as transferrable templates for ex situ epitaxial growth using other techniques. We find that the stability of these templates depends on the thickness of the capping layer.  https://www.selleckchem.com/products/Sunitinib-Malate-(Sutent).html  On these templates, freestanding superconducting SrTiO3 membranes were synthesized ex situ using molecular beam epitaxy, enabled by the lower growth temperature which preserves the sacrificial layer. This study paves the way for the synthesis of an expanded selection of freestanding oxide membranes and heterostructures with a wide variety of ex situ growth techniques.Herein, we report a novel organocatalytic process for synthesis of complex 1,3,4-oxadiazoles from readily accessible aldehydes. By exploiting the nucleophilicity of the putative Breslow intermediate and the inherent electrophilicity of α-diazo iodonium triflate, we have found that N-heterocyclic carbene catalyst promotes efficient cyclization of various aldehydes and α-diazo iodonium triflates. The reaction proceeds under mild conditions with a wide range of functional group tolerance. The heterocyclic products can be readily further functionalized, rendering the protocol highly valuable.Recently, hybrid perovskites have gained attention as sensitizers for molecular triplet generation. Layered, two-dimensional (2D) perovskites are especially well-suited for this purpose because the triplet donor (inorganic framework) and triplet acceptor (organic layer) are self-assembled into adjacent sheets, so that with the appropriate energetics, triplets can be driven across the interface. Here we examine interlayer energy transfer in a series of mixed-halide Dion-Jacobson 2D perovskites containing divalent naphthalene cations. We find that the sensitized phosphorescence in these compounds is dominated by naphthalene triplet excimer emission, but when the inorganic exciton is tuned near resonance with the naphthalene triplet, naphthalene monomer phosphorescence competes with triplet excimer formation. The interlayer energy-transfer process is further revealed by ultrafast transient absorption spectroscopy through kinetic variations in triplet excimer formation times. Ultimately, gaining control over interlayer interactions in 2D perovskites through cation design will help uncover new functions and applications for these materials.Deciphering the exact electronic and geometric changes of photoexcited molecules is an important task not only to understand the fundamental atomistic mechanisms but also to rationally design molecular properties and functions. Here, we present a combined experimental and theoretical study of the twisted intramolecular charge transfer (TICT) process in hemithioindigo photoswitches. Using ultrafast transient IR spectroscopy as the main analytical method, a detailed understanding of the extent and direction of charge transfer within the excited molecule is obtained. At the same time, the geometrical distortion is monitored directly via changes of indicative vibrational modes over the time course of the photoreaction. These high-resolution data deliver a detailed molecular movie of the TICT process in this important class of chromophores with picosecond time resolution.