Sequential extraction tests were used to study partitioning of U in the bottom sediments of two reservoirs that have been used for the temporary storage of nuclear waste at the "Mining and Chemical Combine" (Zheleznogorsk, Krasnoyarsk region, Russia). Various sequential extraction protocols were applied to the bottom sediment samples and the results compared with those obtained for laboratory-prepared simulated samples with different speciation and partitioning, e.g., U(VI) sorbed onto various inorganic minerals and organic matter, as well as uranium oxides. The distributions of uranium in fractions extracted from simulated and actual contaminated samples were compared to shed light on the speciation of U in the bottom sediments. X-ray absorption spectroscopy, X-ray diffraction, and scanning electron microscopy were also used to analyze the partitioning of U in contaminated sediments. We also compared the results obtained using the spectroscopic and microscopic techniques, as well as sequential extraction.A novel approach is proposed to detect underground nuclear explosions (UNEs) through the displacement of natural radon isotopes (222Rn and 220Rn). Following an explosion, it is hypothesized that the disturbance and pressurization of the sub-surface would facilitate the movement of radon from the depth of the UNE towards the surface resulting in increased soil gas activity. The resulting signal may be magnified by a factor of 2.0-4.9 by the decay of radon to its short-lived progeny. Increases in background activity may be useful for identifying locations to perform additional measurements, or as a detectable signal at monitoring stations. To validate this hypothesis, radon detection instrumentation was deployed at the Dry Alluvium Geology (DAG) site of the Source Physics Experiment (SPE) at the Nevada National Security Site (NNSS). Natural fluctuations in the soil gas activity due to barometric pumping, and the lower yield of the chemical explosions (1-50 t) made it difficult to confirm a displacement of radon from the explosions, and further study to validate the proposed hypothesis is recommended.Within the last decade, Para sport has experienced increased growth, global popularity, and scientific research. Likewise, there is increasing application of systems ergonomics methods to optimise sports performance. Despite this, few studies have attempted to analyse Para sport as a complex system. The aim of this study was to apply a systems ergonomics framework to redesign a current Para sport system via a multi staged approach. The Cognitive Work Analysis framework was used to model and redesign the Para sport system, via the insertion of design interventions. The findings offer insights into the complexity of the Para sport system via the multiple interacting factors that influence the performance of the system. In addition, the design interventions had substantial influence on the Para sport system by creating multiple new processes, functions, measures, and purposes, and enhanced multiple components of the existing system. This study provides a unique contribution to ergonomic science and extends system ergonomics theory and methods in sport. This study has practical implications for policy development by providing a template that can be used by others wanting to optimise able-bodied sport, Para sport, and non-sport systems.This study aimed to investigate the dynamic effects of the traditional Chinese medicine compound Longdan Xiegan Decoction (LXD) on the inhibition of Notch signaling pathway activation and T helper (Th) cell differentiation in rats with experimental autoimmune uveitis (EAU). Based on a network pharmacology strategy, we conducted protein interaction network analysis to construct an active ingredient-disease treatment network. Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were further used to screen out the possible signaling pathways regulated by LXD in the treatment of uveitis. In the subsequent functional studies, we established an EAU rat model and investigated the regulatory role of LXD in the Notch signaling pathway and Th cell differentiation in rats with EAU. Female Lewis rats were randomly divided into a normal control (NC) group, an EAU group, and an LXD group. After the induction of EAU, the ocular inflammation and pathological changes in ter treatment with LXD, the expression of Notch1, DLL4 and IL-17 mRNA and proteins was significantly decreased (all P  less then  0.05), and the CD4+/CD8+ and Th17/Treg ratios significantly gradually returns to balance. LXD can efficiently inhibit Th17 cell differentiation, decrease inflammatory cytokine expression, and restore the CD4+/CD8+ and Th17/Treg balance by inhibiting the activation of the Notch signaling pathway in rats with EAU, thus effectively alleviating eye inflammation, protecting eye tissue structures, and positively regulating the immune state of the whole body and the intraocular microenvironment.Heart valve replacement is a very effective method to treat severe valvular stenosis or valvular insufficiency. The valve can be divided into the mechanical valve and biological valve according to the main materials of the valve leaflets. The former has good durability, but the patients need to take anticoagulants all their lives, otherwise, thrombosis will occur; the latter has good blood compatibility, and only 3-6 months of postoperative anticoagulation is required, but its durability is lower than the former. Compared with a traditional valve used materials, the fabric composite valve leaflets have both mechanical valve and biological valve advantages, i.e.  https://www.selleckchem.com/products/fht-1015.html  it can have both good blood compatibility and excellent fatigue resistance. This material is comprised of the internal fabric layer and bilateral external polyurethane layers jointed with adhesive, and it can adjust the flexibility, wear-resistance and fatigue resistance of the valve leaflet through adjusting the thickness of the outer polyurethane protective layer, the weaving method, the fiber diameter and the surface density of the inner ultra-high molecular weight polyethylene (UHMWPE) fabric. In this article, we tested the long-term durability of a fabric composite with its property close to the valve leaflet made of bovine pericardium, to evaluate the material performance loss under long-term fatigue and the wear degree of this material with different polyurethane layer thicknesses. As many as two hundred million cycles of fatigue test and the hydrodynamic performance test before and after the fatigue test proved that the material could withstand a service life of at least five years without structural failure or functional degradation. According to the SEM images after the experiment, it can be predicted that this material can achieve a longer fatigue life.