https://www.selleckchem.com/products/17-AAG(Geldanamycin).html The concentration of nitrate (NO3-) in Narragansett Bay has been shown to undergo considerable temporal and spatial variation. However, the dynamics of this flux has never been monitored on a fine-scale ( less then 100 m, less then 1 d) or in real-time. Whole-cell bio-reporters are promising candidates for low cost environmental sensing of bioavailable nutrients. Yet difficulties remain in creating sensors for long term deployment in the marine environment. This paper describes the creation and validation of a low-cost sensor using a self-bioluminescent strain of the cyanobacteria Synechococcus elongatus pcc 7942 for the direct measurement of bioavailable nitrate. Nitrate bioavailability was measured by monitoring light emission from a luxAB based promotor fusion to glnA using a light to frequency sensor and single board microcontroller. Sensor designs are presented in this manuscript with specific focus on storage, cell viability, and compatibility with the marine environment. Sensors were able to consistently assess nitrate standards as low as 1 ppm (16.3 μM). Using a wavelet denoising approach to reduce white noise and hardware noise, nitrate detection of standards as low as 0.037 ppm (0.65 μM) was achieved. Good sensitivity and low cost make these sensors ideal candidates for continuous monitoring of biological nitrates in estuarine systems.Olfactory dysfunction, one of the earliest non-motor symptoms of Parkinson disease (PD), is accompanied by abnormal deposition of SNCA/α-synuclein in the olfactory bulb (OB). The macroautophagy/autophagy-lysosome pathway (ALP) plays an important role in degrading pathological SNCA and modulating this pathway may be a promising treatment strategy. P2RX4 (purinergic receptor P2X, ligand-gated ion channel 4), a member of the purinergic receptor X family, is a key molecule regulating ALP. Piperine (PIP) is a Chinese medicine with anti-inflammatory and anti-oxidant eff