To determine the current role of bisantrene, an anthracene with anthracycline-like activity which was shown in earlier studies to be effective therapy in relapsed/refractory acute myeloid leukemia with no discernible cardiotoxicity, in the treatment of patients with R/R AML.
 
  This phase 2, single-center study (NCT03820908) enrolled adult R/R AML to receive bisantrene (250mg/m
  daily for 7days) which was administered via an intravenous infusion over 2hours on days 1-7. Disease assessment included routine blood work and bone marrow studies.
 
  In all, 10 patients were enrolled with a median of 3 lines of prior therapy including seven patients who had relapsed following allogeneic stem cell transplantation. The most frequently reported grade ≥3 treatment-attributed hematologic AE was thrombocytopenia, whereas the most frequently reported grade ≥3 treatment-attributed non-hematologic AE was mucositis. Of the 10 patients, one (10%) achieved a complete remission and three patients achieved a partial remission resulting in an overall response rate of 40%. Next-generation sequencing of patient samples identified a wide array of mutations associated with activated signaling, splicing, and epigenetic modification.
 
  In view of the observed low toxicity, a follow-up study combining bisantrene with complementary anti-leukemic therapy is planned.
 In view of the observed low toxicity, a follow-up study combining bisantrene with complementary anti-leukemic therapy is planned.By analyzing the gene expression of endometrial carcinoma (EC) patients, the key factors in PI3K signaling pathway and its related genes mediating EC were explored. The EC samples and normal endometrial samples were downloaded from TCGA database and GTEx database. The R language "limma" package was used for differential analysis, and the expression level of genes in each tissue was analyzed by "gganatogram" package. Functional enrichment analysis of differential genes was carried out by KOBAS, an online bioinformatics website. The correlation between key genes and differential genes was evaluated using TCGA data and GTEx combined gene expression data. The corresponding clinical data were downloaded from TCGA database and GTEx database, and the R language "survival" package was used to assess the potential of candidate differential genes as a key factor of EC. Based on the combined differential analysis of TCGA and GTEx databases, 299 genes with significant differential in expression were finally got. Functionhey may be potential markers for the prognosis of patients with EC.The purpose of this study was to evaluate the relationships of smoking, alcohol consumption, and obesity with thyroid cancer in Korean residents.  https://www.selleckchem.com/products/choline-hydroxide.html  The Korean National Health Insurance Service-Health Screening Cohort includes individuals ≥ 40 years who were assessed from 2002 to 2013. In total, 4977 thyroid cancer participants were matched with respect to age, sex, income, and region of residence with 19,908 controls at a ratio of 14. Crude and adjusted (for the Charlson comorbidity index, smoking status, frequency of alcohol consumption, and obesity) odds ratios (ORs) were analyzed using conditional logistic regression analyses. Additionally, 95% confidence intervals (CIs) were calculated. The adjusted OR of smoking for thyroid cancer was 0.62 (95% CI 0.54-0.72, P  less then  0.001), and that of alcohol consumption was 0.83 (95% CI 0.75-0.92, P  less then  0.001). The adjusted ORs of the BMI categories were 1.13 (95% CI 1.05-1.22, P = 0.002) for obese I, and 1.24 (95% CI 1.04-1.47, P = 0.014) for obese II. The ORs of smoking and alcohol consumption were lower, and those of overweight and obesity were higher in thyroid cancer patients than in individuals in the control group.An amendment to this paper has been published and can be accessed via a link at the top of the paper.Autism spectrum disorder (ASD) is characterized by a core deficit in theory-of-mind (ToM) ability, which extends to perturbations in moral judgment and decision-making. Although the function of the right temporoparietal junction (rTPJ), a key neural marker of ToM and morality, is known to be altered in autistic individuals, the neurocomputational mechanisms underlying its specific impairment in moral decision-making remain unclear. Here, we addressed this question by employing a novel fMRI task together with computational modeling and representational similarity analysis (RSA). ASD patients and healthy controls (HC) decided in public or private whether to incur a personal cost for funding a morally-good cause (Good Context) or receive a personal gain for benefiting a morally-bad cause (Bad Context). Compared with HC, individuals with ASD were much more likely to reject the opportunity to earn ill-gotten money by supporting a bad cause than HC. Computational modeling revealed that this resulted from unduly wein immoral action can benefit themselves, and suffer an undue concern about their ill-gotten gains and the moral cost. Moreover, a selectively reduced rTPJ representation of information concerning moral rules was observed in ASD patients. These findings deepen our understanding of the neurobiological roots that underlie atypical moral behaviors in ASD patients.Editor's NoteThe authors have been made aware of concerns and are working to address them in proofs, before the final version of this article is published.Arthropod herbivores cause substantial economic costs that drive an increasing need to develop environmentally sustainable approaches to herbivore control. Increasing plant diversity is expected to limit herbivory by altering plant-herbivore and predator-herbivore interactions, but the simultaneous influence of these interactions on herbivore impacts remains unexplored. We compiled 487 arthropod food webs in two long-running grassland biodiversity experiments in Europe and North America to investigate whether and how increasing plant diversity can reduce the impacts of herbivores on plants. We show that plants lose just under half as much energy to arthropod herbivores when in high-diversity mixtures versus monocultures and reveal that plant diversity decreases effects of herbivores on plants by simultaneously benefiting predators and reducing average herbivore food quality. These findings demonstrate that conserving plant diversity is crucial for maintaining interactions in food webs that provide natural control of herbivore pests.