01, CI [1.22-3.31]; P = .006). Conclusion During the COVID-19 pandemic, the prevalence of burnout, anxiety, and distress is high among academic otolaryngologists.Microtubule-associated protein Tau, abundant in the central nervous system (CNS), plays crucial roles in microtubule assembly and stabilization. Abnormal Tau phosphorylation and aggregation are a common pathogenic hallmark in Alzheimer's disease (AD). Hyperphosphorylation of Tau could change its conformation and result in self-aggregation, increased oxidative stress, and neuronal death. In this study, we examined the potential of licochalcone A (a natural chalcone) and five synthetic derivatives (LM compounds) for inhibiting Tau misfolding, scavenging reactive oxygen species (ROS) and providing neuroprotection in human cells expressing proaggregant ΔK280 TauRD -DsRed. All test compounds were soluble up to 100 μM in cell culture media and predicted to be orally bioavailable and CNS-active. Among them, licochalcone A and LM-031 markedly reduced Tau misfolding and associated ROS, promoted neurite outgrowth, and inhibited caspase 3 activity in ΔK280 TauRD -DsRed 293 and SH-SY5Y cells.  https://www.selleckchem.com/products/mavoglurant.html  Mechanistic studies showed that LM-031 upregulates HSPB1 chaperone, NRF2/NQO1/GCLC pathway, and CREB-dependent BDNF/AKT/ERK/BCL2 pathway in ΔK280 TauRD -DsRed SH-SY5Y cells. Decreased neurite outgrowth upon induction of ΔK280 TauRD -DsRed was rescued by LM-031, which was counteracted by knockdown of NRF2 or CREB. LM-031 further rescued the downregulated NRF2 and pCREB, reduced Aβ and Tau levels in hippocampus and cortex, and ameliorated cognitive deficits in streptozocin-induced hyperglycemic 3 × Tg-AD mice. Our findings strongly indicate the potential of LM-031 for modifying AD progression by targeting HSPB1 to reduce Tau misfolding and activating NRF2 and CREB pathways to suppress apoptosis and promote neuron survival, thereby offering a new drug development avenue for AD treatment.200 years ago Ørsted laid the foundation of electromagnetism in his famous experiment deflecting a magnetic needle in the electrical field of a platinum wire. For this he used his own Cu-Zn trough battery, which was among the best then available, but 21 years later it was surpassed by the coal-zinc battery invented by Bunsen, which became highly successful and acclaimed. That year, 1841, Bunsen made his first direct contact with Scandinavia when he visited Berzelius in Stockholm, Palmstedt in Gothenburg, and Ørsted, Scharling and Zeise in Copenhagen. Like almost everybody in continental Europe, they adopted Bunsen's battery, and Ørsted used it for his experiments with a very large electromagnet. The paths of Ørsted's and Bunsen's researches crossed again much later through the synthesis of elemental aluminum, which was first achieved by Ørsted in 1825 (although it was probably not obtained as the pure metal) and performed quite differently by Bunsen, by electrolysis using his coal-zinc battery, in 1854.Wound care is an important realm of nurses' clinical responsibilities, and a broad knowledge and range of skills are needed to perform efficient and safe patient care. Nurses' knowledge on this matter can be measured using knowledge tests. This study aims to identify, define, and analyse the knowledge tests developed for the measurement of nurses' wound care knowledge, and to evaluate the psychometric properties of the tests. This study was a systematic literature review. A total of 52 studies and 18 instruments were found. Of the 18 instruments, only 5 had been used more than once and were successful in a psychometric evaluation. These five instruments were analysed on the basis of their psychometric properties by using Zwakhalen et al.'s (2006) psychometric testing framework. According to the analysis, the Pressure Ulcer Knowledge Test (PUKT) and the Pressure Ulcer Knowledge Assessment Tool (PUKAT) were the most valid and reliable instruments for measuring nurses' wound care knowledge. Most of the instruments identified and analysed focused on pressure ulcers, indicating that future instruments could focus more on other types of wounds or on wound care in general in order to receive a broader understanding of nurses' wound care knowledge.Intestinal fibrosis and subsequent strictures are major clinical challenges in inflammatory bowel disease, resulting in an increased rate of operation and poor prognosis. With the perception of intestinal fibrosis changing from being irreversible to reversible disease in recent years, various candidate serum biomarkers have been studied over the past decades, which may potentially stratify patients based on the stenosis developing risk and enable to detect the early stages of fibrosis. However, reliable and accurate biomarkers are still unavailable due to conflict results and lacking evidence with high quality. In this review we summarized serum biomarkers proposed for intestinal fibrosis in recent years, which includes gene polymorphisms or variants, epigenetic markers, extracellular matrix components, growth factors and antibodies, aiming to provide clues for future research. This article is protected by copyright. All rights reserved.Aim To assess whether relative age was associated with bullying involvement and whether the associations were independent of child psychiatric symptoms. Methods Bullying was assessed among 8576 children in the second grade, aged 8 years, by using four cross-sectional population-based studies with identical methodology completed by children, parents and teachers in 1989 (response rate 97%), 1999 (93%), 2005 (90%) and 2013 (86%). The main outcomes were bullying victimisation and perpetration. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated with the relatively oldest as the reference group and adjusted for child psychiatric symptoms. Results The relatively youngest children, born September to December, were compared with the relatively oldest, born January to April. The youngest children had increased odds of being victims according to child (OR 1.2, 95% CI 1.1-1.4) and parent reports (OR 1.2 95% CI 1.008-1.4). The youngest also had decreased odds of being perpetrators according to child (OR 0.