Peri-implant bone tissue enhancement by the sub-periosteal peri-implant increased level strategy plus a bovine-derived bone fragments prevent: An incident record.
  Mortality may be lowered when cases are relatively mild, and there are sufficient medical resources to care and treat the disease. © 2020 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.OBJECTIVE To assess functional outcomes in patients treated by compartmental tongue surgery (CTS) and reconstruction for advanced oral tongue/floor-of-mouth cancer. STUDY DESIGN Retrospective case series. METHODS A retrospective cohort of patients (n = 48) treated by CTS and free flap reconstruction was prospectively evaluated concerning postoperative functional outcomes at different time points (6 months and 1 year). Swallowing was studied by videonasal endoscopic evaluation (VEES) and videofluoroscopy (VFS), testing various food consistencies and grading the results with the Donzelli scale. Speech articulation, lingual strength, and endurance were studied by phone call and Iowa Oral Performance Instrument (IOPI). Subjective tests (EORTC H&N35 and UWQOL) were administered. RESULTS After 1 year, VEES showed a Donzelli scale of 67% level 1, 23% level 2, and 10% level 3. Vallecular pouch was present in 81% of patients. VFS showed levels 1, 2, and 3 in 42%, 25%, and 33%, respectively, with liquids (L); 48%, 19%, and 33%, with semi-liquids (SL); and 54%, 33%, and 13%, with semi-solids (SS). Vallecular pouch residue was present in 69% with L, 73% with SL, and 87% with SS. The mean number of words recognized at phone call was 56 of 75 (range, 27-74). IOPI showed a mean tongue strength of 19.2 kPa (range, 0-40), and a mean endurance of 16.2 seconds (range, 0-60). CONCLUSION CTS does not significantly affect speech. Sub-clinical food aspiration and vallecular pouch are present in a significant proportion of patients, especially when adjuvant treatments are administered. Residual tongue strength is not affected when proper reconstruction is performed. LEVEL OF EVIDENCE 4 Laryngoscope, 2020. © 2020 The American Laryngological, Rhinological and Otological Society, Inc.BACKGROUND This is an updated version of the original Cochrane Review, published in 2016, Issue 7. Sudden Unexpected Death in Epilepsy (SUDEP) is defined as sudden, unexpected, witnessed or unwitnessed, non-traumatic or non-drowning death of people with epilepsy, with or without evidence of a seizure, excluding documented status epilepticus and in whom postmortem examination does not reveal a structural or toxicological cause for death. SUDEP has a reported incidence of 1 to 2 per 1000 patient-years and represents the most common epilepsy-related cause of death. The presence and frequency of generalised tonic-clonic seizures (GTCS), male sex, early age of seizure onset, duration of epilepsy, and polytherapy are all predictors of risk of SUDEP. The exact pathophysiology of SUDEP is currently unknown, although GTCS-induced cardiac, respiratory, and brainstem dysfunction appears likely. Appropriately chosen antiepileptic drug treatment can render around 70% of patients free of all seizures. However, around one-tffect for additional nocturnal supervision (physical checks less then 15 minutes apart; use of listening devices; dormitory setting; and use of bed sensors). However the same study did ascertain a difference between centres the residential centre with the lowest level of supervision had the highest incidence of SUDEP. The case-control studies did not report on quality of life or depression and anxiety scores. AUTHORS' CONCLUSIONS We found limited, very low-certainty evidence that supervision at night reduces the incidence of SUDEP. Further research is required to identify the effectiveness of other current interventions - for example seizure detection devices, safety pillows, SSRIs, early surgical evaluation, educational programmes, and opiate and adenosine antagonists - in preventing SUDEP in people with epilepsy. Copyright © 2020 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.DISEASE OVERVIEW Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm with an incidence of 1-2 cases per 100 000 adults. It accounts for approximately 15% of newly diagnosed cases of leukemia in adults. DIAGNOSIS CML is characterized by a balanced genetic translocation, t(9;22)(q34;q11.2), involving a fusion of the Abelson gene (ABL1) from chromosome 9q34 with the breakpoint cluster region (BCR) gene on chromosome 22q11.2. This rearrangement is known as the Philadelphia chromosome. The molecular consequence of this translocation is the generation of a BCR-ABL1 fusion oncogene, which in turn translates into a BCR-ABL oncoprotein. FRONTLINE THERAPY Four tyrosine kinase inhibitors (TKIs), imatinib, nilotinib, dasatinib, and bosutinib are approved by the United States Food and Drug Administration for first-line treatment of newly diagnosed CML in chronic phase (CML-CP). Clinical trials with second generation TKIs reported significantly deeper and faster responses, but they had no impact on survival proTKI anti-CML agents (hydroxyurea, omacetaxine, azacitidine, decitabine, cytarabine, busulfan, others). © 2020 Wiley Periodicals, Inc.AIM Quantitative studies using validated questionnaires on core competencies of emergency nurses in China are rare and the baseline core competencies must first be evaluated before improvizations to the competencies can be implemented. This study aimed to investigate the factors potentially involved in the level of core competencies of emergency nurses from tertiary hospitals in northwest China. METHODS In this cross-sectional study, male and female emergency nurses (n = 277) from tertiary hospitals of northwest China were enrolled to complete the Competency Inventory for Registered Nurses (CIRN) questionnaire comprising of a total of seven dimensions with 58 items. General self-efficacy and perceived stress were also evaluated. Pearson correlation test and multivariate stepwise linear regression analysis were performed to assess the association between various factors associated with core competencies. RESULTS Senior nurses had higher CIRN scores than junior nurses (p  less then  .001). Married and widowed nurses had higher CIRN scores than unmarried and divorced nurses (p = .008). Nurses satisfied with their career had better CIRN scores than those who were dissatisfied (p  less then  .001). CIRN scores were correlated with age (r = .356, p  less then  .001), working years (r = .374, p  less then  .001), and the general self-efficacy scale (r = .547, p  less then  .001). Multivariable stepwise linear regression analysis showed that higher professional titles and job satisfaction were independently associated with higher CIRN scores (both p  less then  .001).  https://www.selleckchem.com/products/favipiravir-t-705.html  CONCLUSIONS Emergency nurses from tertiary hospitals of northwest China with senior titles and job satisfaction had high CIRN scores which necessitates empowering the junior nurses by way of education and training programs to gain higher core competencies in order to deliver better nursing care to patients.  https://www.selleckchem.com/products/favipiravir-t-705.html  © 2020 Japan Academy of Nursing Science.