This paper presents two studies on the development and validation of a ten-item scale of epistemic vice and the relationship between epistemic vice and misinformation and fake news. Epistemic vices have been defined as character traits that interfere with acquiring, maintaining, and transmitting knowledge. Examples of epistemic vice are gullibility and indifference to knowledge. It has been hypothesized that epistemically vicious people are especially susceptible to misinformation and conspiracy theories. We conducted one exploratory and one confirmatory observational survey study on Amazon Mechanical Turk among people living in the United States (total N = 1737). We show that two psychological traits underlie the range of epistemic vices that we investigated indifference to truth and rigidity. Indifference manifests itself in a lack of motivation to find the truth. Rigidity manifests itself in being insensitive to evidence. We develop a scale to measure epistemic vice with the subscales indifference and rigidity. The Epistemic Vice Scale is internally consistent; has good convergent, divergent, and discriminant validity; and is strongly associated with the endorsement of misinformation and conspiracy theories. Epistemic vice explains additional variance in the endorsement of misinformation and conspiracy theories over and above demographic and related psychological concepts and shows medium to large effect sizes across outcome measures. We demonstrate that epistemic vice differs from existing psychological constructs, and show that the scale can explain individual differences in dealing with misinformation and conspiracy theories. We conclude that epistemic vice might contribute to "postfactive" ways of thinking.
  The online version contains supplementary material available at 10.1007/s13164-021-00562-5.
 The online version contains supplementary material available at 10.1007/s13164-021-00562-5.Urbanisation is changing food systems globally, and in particular in sub-Saharan Africa and South Asia. This transformation can affect rural livelihoods in multiple ways. Evidence on what enabling conditions are needed to materialise the opportunities and limit risks is scattered. Here we review scientific literature to elaborate on how urbanisation affects food systems, and on the enabling conditions that subsequently shape opportunities for rural livelihoods. We find that urbanisation leads to a rising and changing food demand, both direct and indirect land use changes, and often to more complex market linkages. Evidence shows that a wide range of enabling conditions can contribute to the materialisation of opportunities for rural livelihoods in this context. Reviewed evidence suggests that the connectivity to urban centres is pivotal, as it provides access to finance, inputs, information, services, and off-farm employment. As a result, physical and communication infrastructure, the spatial pattern of urbanisation, and social networks connecting farmers to markets are identified as important enabling factors for the improvement of rural livelihood outcomes. Our findings suggest that coordinated and inclusive efforts are needed at different scales to make sure rural livelihoods benefit from urbanisation and food system transformation.Agriculture is the most natural resource-intensive and climate-sensitive sector. This study examines the perceptions and attitudes of small family farmers toward climate change and identifies adaptation strategies supporting household food security in the Middle Eastern context, Lebanon. The study uses cross-sectional, primary data of households that own small family farms in the Central Bekaa region. The results show that the majority of the households believe that climate change is occurring, has adverse impacts on livelihoods, and is attributable to human factors. They perceived an increase in temperature and a decrease in rainfall patterns over the last 20 years.  https://www.selleckchem.com/products/2-aminoethyl-diphenylborinate.html  In response, the households used multiple agricultural practices to adapt to climate change. Based on the Household Food Insecurity Access Scale (HFIAS) scores, only 7.5% of the households were food secure, while 89% were mild to moderately food insecure. Generally, the households had modest access to nutritious diets. All the households used two or more environmentally sustainable agricultural practices. However, the use of multiple environmentally sustainable practices did not correlate with improved food security. This latter result may be due to the limited knowledge of the farmers about trade-offs between various climate change adaptation measures. The findings suggest the need to refocus research from the question of whether small family farmers are willing to adopt (or not) climate change adaptation practices to identifying those practices that are capable of balancing economic, social, and environmental goals in a specific context.
  This study investigated changes in small-world topology and brain functional connectivity in patients with optic neuritis (ON) by resting-state functional magnetic resonance imaging (rs-fMRI) and based on graph theory.
 
  A total of 21 patients with ON (8 males and 13 females) and 21 matched healthy control subjects (8 males and 13 females) were enrolled and underwent rs-fMRI. Data were preprocessed and the brain was divided into 116 regions of interest. Small-world network parameters and area under the integral curve (AUC) were calculated from pairwise brain interval correlation coefficients. Differences in brain network parameter AUCs between the 2 groups were evaluated with the independent sample 
  -test, and changes in brain connection strength between ON patients and control subjects were assessed by network-based statistical analysis.
 
  In the sparsity range from 0.08 to 0.48, both groups exhibited small-world attributes. Compared to the control group, global network efficiency, normalized clustering c HC brain networks. The brain network in ON has a small-world attribute but shows reduced and abnormal connectivity compared to normal subjects and likely causes symptoms of cognitive impairment.Diabetic nephropathy (DN) is one of the most lethal complications of diabetes mellitus with chronic inflammation. We have examined the role of the inflammatory chemokine CCL24 in DN. We observed that serum levels of CCL24 were significantly elevated in patients with DN. Not only that, the expression of CCL24 was significantly increased in the kidneys of DN mice. The kidney of DN mice showed increased renal fibrosis and inflammation. We characterized an in vitro podocyte cell model with high glucose. Western blot analysis showed that expression of CCL24 was significantly increased under high-glucose conditions. Stimulation with high glucose (35 mmol/L) resulted in an increase in CCL24 expression in the first 48 hours but changed little after 72 hours. Moreover, with glucose stimulation, the level of podocyte fibrosis gradually increased, the expression of the proinflammatory cytokine IL-1β was upregulated, and the expression of the glucose transporter GLUT4, involved in the insulin signal regulation pathway, also increased.