Background Several studies suggest that maternal obesity might be associated with intraoperative and postoperative complications of cesarean delivery. However, these results are not validated in the Pakistani population. Aim We aimed to assess the association between maternal obesity and intraoperative and postoperative complications of cesarean delivery. Methods We performed a retrospective observational study recording the prevalence of intraoperative and postoperative complications in women undergoing cesarean delivery. For all consecutive cesarean deliveries in Fehmida Sarfaraz hospital, Sialkot, Pakistan, we recorded the data of the maternal age, weight, body mass index (BMI), gestational age at delivery, intraoperative and postoperative complications, and the adverse pregnancy outcomes. We used the chi-square test, Spearman correlation, and linear regression to test the relationship between the study variables. Results We included 245 women in this study (non-obese group n = 83; obese group n = 162). BMI positively correlated with the incidence of deep venous thrombosis (DVT; r = 0.249), endometritis (r = 0.148), pyrexia (r=0.139), and wound infections (r = 0.155). Also, BMI could significantly predict DVT (Beta coefficient 2.886, P = 0.003), hospital stay (Beta coefficient 0.801, P = 0.001), pyrexia (Beta coefficient 0.819, P = 0.003), and wound infection (Beta coefficient 0.449, P = 0.049). Conclusion Our data suggest that BMI was significantly correlated with several cesarean section (CS) delivery complications. Obese women undergoing CS delivery are at higher risk of several CS delivery complications. Also, they had a longer hospital stay and higher birth weight for their neonates compared with non-obese women. Future multicentre studies are needed in our population to determine the magnitude of risk across different BMI subgroups. Copyright © 2020, Saadia et al.Colonic perforation is an uncommon but known and feared complication of colonoscopy, which carries a high mortality rate. We present an uncommon case of extensive intra- and extraperitoneal air following colonic perforation in a patient undergoing inpatient colonoscopy for evaluation of unintentional weight loss and constipation. During colonoscopy, a splenic flexure stricture was identified and dilated. Postprocedural hemodynamic instability prompted further imaging which revealed pneumoperitoneum, bilateral pneumothorax, pneumomediastinum, pneumopericardium, and severe subcutaneous emphysema. Emergent exploratory laparotomy found perforation of the proximal transverse colon which required resection and transverse colostomy placement. The patient also underwent bilateral chest tube placement and was treated with antibiotics for peritonitis. The patient was eventually diagnosed with Crohn's disease and discharged to an extended care facility with outpatient follow-up. Extraperitoneal colonic perforations are fairly rare, and to our knowledge, we present the most severe case that has been published in recent years. Copyright © 2020, Weng et al.Crohn's disease is a systemic illness with a plethora of extraintestinal manifestations affecting various organs, of which the lungs are relatively rare. Pulmonary involvement may include airway diseases, lung parenchymal diseases, pleural diseases, or drug-related diseases. Tracheobronchial involvement is the most common respiratory presentation, whereas Crohn's disease-related interstitial lung disease is seen less frequently. A 41-year-old woman with a past medical history of Crohn's disease (status-post subtotal colectomy) presented to the hospital for an enlarging ground-glass opacity in her right middle lobe detected on routine computed tomography of the abdomen six months earlier. The opacity had increased in size from 21 x 18 mm to 28 x 18 mm and another ground-glass opacity in the right lower lobe increased in size from 5 mm to 12.4 mm. A robotic right middle lobectomy with lymph node dissection was done and bronchoscopy showed benign nodular lymphoid hyperplasia and a single perivascular epithelioid dealing with Crohn's disease to avoid further impairment of health status and alleviate patient symptoms by prompt recognition and treatment. Copyright © 2020, Garg et al.Proper craniocervical alignment during craniocervical reduction, stabilization, and fusion optimizes cerebrospinal fluid (CSF) flow through the foramen magnum, establishes the appropriate "gaze angle", avoids dysphagia and dyspnea, and, most importantly, normalizes the clival-axial angle (CXA) to reduce ventral brainstem compression. To illustrate the metrics of reduction that include CXA, posterior occipital cervical angle, orbital-axial or "gaze angle", and mandible-axial angle, we present a video illustration of a patient presenting with signs and symptoms of the cervical medullary syndrome along with concordant radiographic findings of craniocervical instability as identified on dynamic imaging and through assessment of the CXA, Harris, and Grabb-Oakes measurements. Copyright © 2020, Henderson et al.Introduction Sexual function is one of the aspects upon which quality of life (QoL) is based. Although previous studies have evaluated the influence of sacrococcygeal pilonidal sinus disease (SPSD) on QoL, no data are available on the influence of SPSD on sexual function in a highly active sexual population based on the age range. The aim of this prospective study was to evaluate whether SPSD has a negative impact on sexual function and whether this is influenced by the surgical treatment of SPSD. Methods  Sexual function was pre- and postoperatively assessed by the Sexual Self-Consciousness Scale (SSCS; score range 0-48), subdivided into the sexual embarrassment (SE; score range 0-24) and sexual self-focus subscale (SFF; score range 0-24). The higher the score, the higher is the sexual dysfunction.  https://www.selleckchem.com/products/gcn2ib.html  Patients were also asked whether SPSD influenced their sexual functioning. Results  A total of 88 male patients who underwent surgical treatment for SPSD were included in the study. The mean (±SD) preoperative SSCS score was 14.5±9.1 and 13.9±8.4 two weeks postoperatively (p=0.394). Six and twelve weeks after surgery, there was a significant reduction to 12.2±9.0 (p=0.002) and 12.3±8.8 (p=0.013), respectively. SE decreased from 5.5±5.1 preoperatively to 5.1±4.6 (p=0.258), 4.2±4.7 (p=0.004) and 4.0±4.6 (p=0.013) two, six, and twelve weeks after surgery. For SFF, there was a decrease from 9.0±5.0 to 8.9±4.9 (p=0.717), 7.8±5.2 (p=0.004) and 8.2±5.3 (p=0.168), respectively. Preoperatively, 70% of the patients totally or partially disagreed that SPSD influenced their sexual functioning, and this increased to 80% of the patients 12 weeks after surgery. Conclusion  This prospective study showed a significant decrease in sexual dysfunction, both six and twelve weeks after surgery, compared to preoperatively in patients suffering from SPSD. Copyright © 2020, Pronk et al.