Purpose This study aims to (1) establish GENEActiv intensity cutpoints in older adults and (2) compare the classification accuracy between dominant (D) or non-dominant (ND) wrist, using both laboratory and free-living data. Methods Thirty-one older adults participated in the study. They wore a GENEActiv Original on each wrist and performed nine activities of daily living. A portable gas analyzer was used to measure energy expenditure for each task. Testing was performed on two occasions separated by at least 8 days. Some of the same participants (n = 13) also wore one device on each wrist during 3 days of free-living. Receiver operating characteristic analysis was performed to establish the optimal cutpoints. Results For sedentary time, both dominant and non-dominant wrist had excellent classification accuracy (sensitivity 0.99 and 0.97, respectively; specificity 0.91 and 0.86, respectively). For Moderate to Vigorous Physical Activity (MVPA), the non-dominant wrist device had better accuracy (ND sensitivity 0.90, specificity 0.79; D sensitivity 0.90, specificity 0.64). The corresponding cutpoints for sedentary-to-light were 255 and 375 g · min (epoch independent 42.5 and 62.5 mg), and those for the light-to-moderate were 588 and 555 g · min (epoch-independent 98.0 and 92.5 mg) for the non-dominant and dominant wrist, respectively.  https://www.selleckchem.com/products/lenalidomide-s1029.html  For free-living data, the dominant wrist device resulted in significantly more sedentary time and significantly less light and MVPA time compared to the non-dominant wrist.This article is the result of an ethnographic work on baton twirling clubs in Switzerland clubs with few members coming from a modest origin, offering a social and physical activity with little resonance, composed of children, and young girls. The supervision is mainly the responsibility of close volunteers family members, friends or neighbors and, for the majority of them, women. It is therefore an environment where people know each other, where gestures of familiarity are the rule and where tensions may sometimes arise due to various conflicts of proximity. Baton twirling is based on a public display of participants and the competitive aspiration for a self-presentation that solicits feminine stereotypes. It shows sociabilities and socialities framed by gender and age relationships within clubs, knowledge transmission and childcare are combined in women's practices. The relationships between women and children transcend learning relationships. These relationships, which go beyond a vertical transmission of knowledge, call for approaches inspired by the theories of care. What is the meaning of these relationships based on women's care from the point of view of sociality and in relation to the institution of sport? This is the main question that will be addressed here. Approaches of care emphasize accompaniment, maintenance. They seem to be a good way to identify the contours of a "sports maternalism" which makes such a commitment valid while at the same time conferring legitimacy on a sports practice that is poorly considered.High-throughput screening of cell-biomaterial interactions combined with machine learning algorithms leads the way toward the future of medical device manufacturing in silico modeling of cell and tissue response. Bio-compatible medical implants will have a huge clinical impact.
  Heterogeneous government responses have been reported in reaction to COVID-19. The aim of this study is to generate an exploratory review of healthcare policies published during COVID-19 by health-care institutions in Mexico. Analyzing policies within different health sub-systems becomes imperative in the Mexican case due to the longstanding fragmentation of the health-care system and health inequalities.
 
  Policies purposely included in the analysis were published by four public health institutions (IMSS, ISSSTE, SSA and PEMEX) during the COVID-19 epidemic in Mexico (from February 29th to June 15th, 2020) on official institutional websites. Researchers reviewed each document and classified them into seven policy categories set by the Rapid Research Evaluation and Appraisal Lab (RREAL) public health response, health-care delivery, human resources, health-system infrastructure and supplies, clinical response, health-care management, and epidemiological surveillance.
 
  Policy types varied by health institution. The largest number of policies were aimed at public health responses followed by health-care delivery and human resources. Policies were mainly published during the community transmission phase.
 
  The pandemic exposed underlying health-care system inequalities and a reactive rather than prepared response to the outbreak. Additionally, this study outlines potential policy gaps and delays in the response that could be avoided in the future.
 The pandemic exposed underlying health-care system inequalities and a reactive rather than prepared response to the outbreak. Additionally, this study outlines potential policy gaps and delays in the response that could be avoided in the future.
  Venous thrombo-embolism is now well-recognised as a common complication of severe COVID-19 disease. Arterial thrombosis has been less well recognised, although it is increasingly reported, mostly in the context of myocardial infarction and stroke.
 
  A 63-year-old man developed a pale, cold foot with an absent dorsalis pedis pulse 7 days into his admission with COVID-19. A CT angiogram demonstrated a large thrombus in the lower thoracic aorta, which had not been present on CT pulmonary angiogram the preceding week, along with occlusion of both popliteal arteries. He was managed with therapeutic dose of low molecular weight heparin (LMWH) for 6 weeks.
 
  This case adds to the growing list of potential sites and consequences of thrombosis in COVID-19.
 
  This case underscores the urgent need for pathophysiological studies and clinical trials to target treatments and guidelines for thromboprophylaxis in COVID-19.
 This case underscores the urgent need for pathophysiological studies and clinical trials to target treatments and guidelines for thromboprophylaxis in COVID-19.