Long-term sequelae of coronavirus disease 2019 (COVID-19) due to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are now recognized. However, there is still a lack of consensus regarding the terminology for this emerging chronic clinical syndrome, which includes long COVID, chronic COVID syndrome, post-COVID-19 syndrome, post-acute COVID-19, and long-hauler COVID-19. In this review, I will use the term "long COVID". A review of the medical history and epidemiology of past pandemics and epidemics in modern literature review identifies common long-term post-infectious disorders, with the common finding of altered cognition. In the brain, the cerebral hypoxia induced by SARS-CoV-2 infection may be caused by mitochondrial dysfunction, resulting in "brain fog". Historically, the common symptom of altered cognition has been reported during earlier pandemics, which include the influenza pandemics of 1889 and 1892 (Russian flu), the Spanish flu pandemic (1918-1919), encephalitis lethargica, diphtheria, and myalgic encephalomyelitis (chronic fatigue syndrome or post-viral fatigue syndrome). There are similarities between chronic fatigue syndrome and the "brain fog" described in long COVID. During past viral epidemics and pandemics, a commonality of neural targets may have increased viral survival by conformational matching. The neurological and psychiatric sequelae of SARS-CoV-2 infection, or long COVID, may have emerged from neural effects that have emerged from an invertebrate and vertebrate virosphere. This review aims to present a historical overview of infections and disorders associated with neurological and psychiatric sequelae that have shown similarities with long COVID.BACKGROUND At present, promptly diagnosing sialolithiasis is easy with the assistance of various noninvasive diagnostic procedures. However, the treatment of parotid sialolithiasis remains inadequate. An immense challenge for oral maxillofacial practitioners is the treatment of large radiolucent stones, especially of those that are located in a hard-to-approach positions in the salivary ducts. This case report aims to propose the protocol of a new technique to improve the management of parotid salivary stones. In 2017, our hospital was the first medical center in Vietnam to implement this technique in the treatment of parotid sialolithiasis. CASE REPORT A 38-year-old man was diagnosed with parotid sialolithiasis based on ultrasound and computed tomography (CT) scanning results. He underwent ultrasound-guided sialendoscopy with holmium yttrium aluminum garnet (YAG) laser lithotripsy. The stone was large (22×12 mm) and in an unfavorable position. A narrow strip of fibrous tissue in front of the stone was also noted. However, 1 week after surgery the patient had local swelling of the parotid gland and no manifestation of inflammation, facial paralysis, or obstructed saliva through the drainage ducts. The patient was examined for clinical symptoms and glandular ultrasound at 3 months and 6 months after the procedure. The follow-up examination results showed normal parotid gland function, no complications or recurrence of stones, and no narrowing of the gland duct. CONCLUSIONS Ultrasound-guided sialendoscopy with holmium YAG laser is safe and effective for treating parotid salivary gland stones.BACKGROUND Everolimus (EVL) plus tacrolimus (TAC) therapy is effective and safe in renal transplantation. However, the pharmacokinetic and pharmacodynamic information for EVL combined with TAC is limited. We investigated the pharmacodynamic drug-drug interaction between EVL and TAC at their therapeutic concentration range. MATERIAL AND METHODS Isolated peripheral blood mononuclear cells (PBMCs) from 22 healthy participants aged 22 to 24 years were cultured with concanavalin A (Con A) in the presence of EVL and/or TAC for 4 days, and the proliferation rate of the PBMCs was calculated. RESULTS TAC promoted the inhibitory efficacy of EVL against the mitogen-activated proliferation of PBMCs at the EVL therapeutic concentration range. When 0.175 ng/mL or more of TAC was combined with 30 ng/mL or more of EVL, the antagonistic effect of TAC on the inhibitory efficacy of EVL against the mitogen-activated proliferation of PBMCs was observed. Conversely, when 0.4 ng/mL TAC and 10 ng/mL or more of EVL were combined, the antagonistic effect of EVL on the inhibitory efficacy of TAC against the mitogen-activated proliferation of PBMCs was observed.  https://www.selleckchem.com/products/atuzabrutinib.html  CONCLUSIONS The pharmacodynamic synergistic efficacy of EVL and TAC in combination on mitogen-activated PBMCs was evident at the therapeutic concentration range, which is used in renal transplantation. However, these drugs antagonize each other to suppress the proliferation of activated PBMCs at concentrations higher than those clinically used.The Hospice and Palliative Nurses Association's 14th Annual Clinical Practice Forum was designed by hospice and palliative nurses for the hospice and palliative nursing community to support a collaborative educational offering focusing on how nurses lead and transform care for individuals and their families who are facing serious illness. The 2020 abstracts presented here assist in advancing our conference aim and reflect the latest scientific research, quality improvement projects and works in progress from hospice and palliative clinicians. These abstracts are intended to provide learners with a framework to improve patient outcomes through the dissemination of evidence-based palliative research and clinical innovations for potential application into individual practice settings.Dyspnea can be assessed using self-rating scales but, as death approaches, self-reporting becomes difficult. The validated Respiratory Distress Observation Scale measures dyspnea distress. The aim of this study was to develop the Italian version of the Respiratory Distress Observation Scale and to examine its psychometric properties. This was a cross-sectional study, analyzing cultural and linguistic validation, content validity, and psychometric properties. Eighty-nine palliative care subjects were enrolled to validate the Italian version of the Respiratory Distress Observation Scale. Patients had an average age of 74.5 (SD, 11.6) years, and 52% (n = 46) were female. Fourteen experts in palliative care evaluated the Italian Respiratory Distress Observation Scale in terms of the content validity ratio and the content validity index (CVI). The Italian Respiratory Distress Observation Scale was reported with an internal consistency (Cronbach α value) of .72 and an overall substantial interrater reliability (Cohen κ method).