Cancer-associated macrophage-like cells (CAMLs) are a potential peripheral blood biomarker for disease progression. This study used data from a phase 2 clinical trial to evaluate prognostic utility of CAMLs for locally advanced non-small-cell lung cancer treated with definitive chemoradiotherapy (CRT) and atezolizumab (DETERRED; ClinicalTrials.gov NCT02525757).
 
  Sample collection occurred at baseline (T0), during CRT (T1), at end of CRT (T2), and at first follow-up (T3). CAMLs were captured and quantified by the CellSieve system using multiplex immunostaining. Giant CAMLs were defined as characteristic CAMLs≥ 50 μm. Kaplan-Meier methodology estimated progression-free survival, distant failure-free survival, relapse-free survival, and overall survival at 30 months.
 
  Thirty-nine patients were evaluated between December 2015 and March 2018. Median follow-up was 27 months. Most disease was stage III (85%) and comprised squamous-cell carcinoma (38%) or adenocarcinoma (59%). In total, 267 blood samples were analyzed. Giant CAMLs were identified in 57%, 60%, 64%, and 63% of patients at T0, T1, T2, and T3, respectively. Patients with giant CAMLs at T3, occurring at a median of 30 days after completion of CRT, had significantly worse distant failure-free survival (hazard ratio [HR] 4.9, P= .015), progression-free survival (HR 2.5, P= .025), recurrence-free survival (HR 2.4, P= .036), and overall survival (HR 3.5, P= .034) compared to patients with small or no CAMLs.
 
  Presence of giant CAMLs after CRT completion was associated with development of metastatic disease and poorer survival despite the use of maintenance immunotherapy. Monitoring CAMLs may help risk-stratify patients for adaptive treatment strategies.
 Presence of giant CAMLs after CRT completion was associated with development of metastatic disease and poorer survival despite the use of maintenance immunotherapy.  https://www.selleckchem.com/products/Temsirolimus.html  Monitoring CAMLs may help risk-stratify patients for adaptive treatment strategies.
  Investigate how prescribing participant-specific joint co-ordinates during model preparation influences the measurement agreement of inverse kinematic (IK) derived unplanned sidestepping (UnSS) lower limb kinematics in OpenSim in comparison to an established direct kinematic (DK) model.
 
  Parallel forms repeatability.
 
  The lower limb UnSS kinematics of 20 elite female athletes were calculated using 1) an established DK model (criterion) and, 2) two IK models; one with (IK
  ) and one without (IK
  ) participant-specific joint co-ordinates prescribed during the marker registration phase of model preparation in OpenSim. Time-varying kinematic analyses were performed using one dimensional (1D) statistical parametric mapping (α=0.05), where zero dimensional (0D) Root Mean Squared Error (RMSE) estimates were calculated and used as a surrogate effect size estimates.
 
  Statistical differences were observed between the IK
  and DK derived kinematics as well as the IK
  and DK derived kinematics. For the IK
  and DK models, mean kinematic differences over stance for the three dimensional (3D) hip joint, 3D knee joint and ankle flexion/extension (F/E) degrees of freedom (DoF) were 46±40% (RMSE=5±5°), 56±31% (RMSE=7±4°) and 3% (RMSE=2°) respectively. For the IK
  and DK models, mean kinematics differences over stance for the 3D hip joint, 3D knee joint and ankle F/E DoF were 70±53% (RMSE=14±11°), 46±48% (RMSE=8±7°) and 100% (RMSE=11°) respectively.
 
  Prescribing participant-specific joint co-ordinates during model preparation improves the agreement of IK derived lower limb UnSS kinematics in OpenSim with an established DK model, as well as previously published in-vivo knee kinematic estimates.
 Prescribing participant-specific joint co-ordinates during model preparation improves the agreement of IK derived lower limb UnSS kinematics in OpenSim with an established DK model, as well as previously published in-vivo knee kinematic estimates.
  Hamstring injuries in athletes can lead to significant time away from competition as a result of persistent posterior thigh pain. These cases are often difficult to treat as the state of the tissues alone cannot explain symptoms. In non-athletic populations with persistent pain, disruptions to tactile, proprioceptive, and spatial cortical representations exist, which has led to promising brain-based treatments. Here, we explored whether athletes with persistent posterior thigh pain also display impairments in these cortical representations.
 
  Cross-sectional study.
 
  Fourteen male professional athletes with persistent posterior thigh pain ('Patients') and 14 pain-free age, sport, body mass index and level-matched controls ('Controls') participated. The tactile cortical representation was assessed using two-point discrimination (TPD) threshold and accuracy of tactile localisation; the proprioceptive cortical representation was assessed using a left/right judgement task; spatial processing was assessed using osterior thigh pain.
  While minimally invasive surgery contributed to improved outcomes in bariatric surgery, less is known about current utilization trends and outcomes related to surgical technique for colorectal resections in super-obese patients (body mass index ≥50 kg/m
  ).
 
  The aim of this study was to compare surgical modalities and short-term outcomes of patients with super obesity who underwent elective colectomy in the United States.
 
  A retrospective review was performed of patients with super obesity who underwent elective colectomy between 2012 to 2018 using the American College of Surgeons National Quality Improvement Program data pool.
 
  Patients were categorized into an open, laparoscopic, or robotic group. Baseline characteristics and perioperative outcomes including 30-day complications and length of stay were compared between the 3 groups. Furthermore, utilization trends of surgical modalities were assessed.
 
  Of 1199 patients, 338 (28.2%) had open, 735 (61.3%) laparoscopic, and 126 (10.5%) robotic colectomy further studied.
  Periprosthetic joint infection is a serious disease with severe consequences for the patient's life. It is not known whether one-stage or two-stage replacement arthroplasty is superior. So far, there have been no studies on short-term complications between both surgical procedures. Therefore, we performed a retrospective study aiming to determine 1) Does two-stage septic exchange arthroplasty have a higher short-term complication rate than one-stage? 2) Is there a difference in length of hospital stay and the in-hospital mortality rate between two- and one-stage septic exchange arthroplasty?
 
  Two-stage septic exchange arthroplasty has a higher short-term complication rate than one-stage.
 
  Retrospectively 429 patients who underwent a one- or two stage revision arthroplasty (288 hips and 141 knees) due to chronic PJI between January 2015 and December 2016 were recruited (one-stage n=385, two-stage n=44). Differences in postoperative complications, surgical therapy, ASA, Charlson Comorbidity Index (CCI), length of hospital, need for plastic surgery, pathogen, in-hospital morbidity and in-hospital mortality were compared using multiple logistic and Poisson regression.