BACKGROUND/OBJECTIVES Little work to date has examined the relationship between gait performance and blood pressure (BP) recovery after standing in later life. The aim of this study is to clarify the association of orthostatic BP with spatiotemporal gait parameters in a large cohort of older people. DESIGN Cross-sectional study using multilevel linear regression to ascertain the difference in orthostatic BP patterns across tertiles of gait speed, and linear regression to analyze the association of orthostatic hypotension 30 seconds after standing (OH-30) with specific gait characteristics. SETTING The Irish Longitudinal Study on Ageing. PARTICIPANTS A total of 4311 community-dwelling adults, aged 50 years or older (mean age = 62.2 years; 54% female), one fifth (n = 791) of whom had OH-30. MEASUREMENTS Continuous orthostatic BP was measured during active stand. OH-30 was defined as a drop in systolic BP of 20 mm Hg or more or drop in diastolic BP of 10 mm Hg or more at 30 seconds. Spatiotemporal gait was assesthey commonly coexist is important, particularly as both are potentially modifiable. © 2020 The American Geriatrics Society.Enteroviruses (EVs) and human parechoviruses (HPeVs) infections are associated with various forms of disease, including gastroenteritis. As information on the molecular epidemiology of these viruses is limited in Ethiopia, the genetic diversity of EV and HPeV was investigated in the Northwestern part of the country. Of the total 450 stool samples obtained from infants and young children with diarrhea, 157 (34.9%) were positive for EV and 49 (10.9%) for HPeV RNA when tested by real-time reverse transcription polymerase chain reaction. Genotyping was performed by sequencing of the EV VP1 gene and the HPeV VP3/VP1 gene, respectively. Genotyping of EV was successful in 118 samples. Thereof, 82 (69.5%) belonged to non-polio EVs as a broad range of genotypes within species C, B, and A. Sabin polioviruses were found in 36 cases. HPeV sequences were also heterogeneous with a relative dominance of genotype 3. In conclusion, diverse EV and HPeV genotypes were found cocirculating in Northwest Ethiopia. The findings highlight the importance of continuous surveillance of these viruses in Ethiopia. © 2020 Wiley Periodicals, Inc.Liposomal vincristine is designed to reduce neurotoxicity and increase dose intensity delivery and has been approved as salvage therapy in relapsed/refractory acute lymphoblastic leukemia (ALL). Our aim was to evaluate the response rate, toxicities, and outcome of adults with newly diagnosed ALL who received liposomal vincristine rather than regular vincristine in combination with intensive chemotherapy (Hyper-CMAD). In a single-center, phase 2 study, patients ≥18 years with newly-diagnosed B-cell ALL were eligible to receive hyper-CMAD alternating with high-dose methotrexate and cytarabine. Rituximab was administered in CD20 positive ALL. Tyrosine kinase inhibitors (imatinib or dasatinib) were added in Philadelphia chromosome-positive (Ph-positive) ALL. Thirty-one patients were enrolled, median follow-up of 59 months (0.3-70). Thirteen patients (42%) had CD20 positive ALL, and 21(68%) had Ph-positive ALL. Thirty(97%) achieved complete remission (CR). All 26 patients with abnormal karyotype achieved complete cytogenetic response, and 27/30(90%) achieved negative minimal residual disease status by multicolor flow cytometry. Of 20 evaluable Ph-positive ALL patients, major molecular response was achieved in 19 patients (95%); complete molecular response in 14(70%). Grade 3/4 peripheral neuropathy was observed in 5(16%) with all grade peripheral neuropathy in 21(68%). With a median follow-up of 59 months, 21(68%) patients are alive. The 5-year CR duration and survival rates were 73% and 61%, respectively; median CR duration and survival was not reached and not reached, respectively. Ten(32%) patients died 1, sepsis on C1D10; 4, unknown; 1, post-transplant complications; 4, relapse. Hyper-CMAD with liposomal vincristine is safe and demonstrated high response and survival rates in newly diagnosed ALL. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.PURPOSE Evaluate the effect of a focused ultrasound transducer position and ground plane configuration on magnetic resonance image quality. METHODS The effect of transducer position with respect to the MRI B0 field and the radiofrequency receive coils was evaluated in a breast-specific MRgFUS system with an integrated RF phased array coil. Image signal to noise ratio was evaluated at different transducer locations. The effect of ultrasound transducer ground plane configuration was evaluated using a replica transducer with twelve ground plane configurations. All evaluations were performed at 3 Tesla. RESULTS Both transducer position and ground plane configuration were found to have a considerable effect on overall image SNR. A 67% increase in SNR was achieved by positioning the transducer face perpendicular to the B0 field. A 25% increase in SNR was achieved by segmenting the replica transducer ground plane from one continuous plane to 9 individual segments. CONCLUSIONS Advances in focused ultrasound hardware allow for integrated radiofrequency MRI coils as well as adjustable transducer positioning.  https://www.selleckchem.com/products/wnt-c59-c59.html  The placement of the ultrasound transducer with respect to both the magnetic field and RF coils can have a considerable effect on image SNR and the resulting MR images that are used for MR guided focused ultrasound treatment planning, monitoring and assessment. This article is protected by copyright. All rights reserved.In late December 2019, a cluster of unexplained pneumonia cases has been reported in Wuhan, China. A few days later, the causative agent of this mysterious pneumonia was identified as a novel coronavirus. This causative virus has been temporarily named as severe acute respiratory syndrome coronavirus 2 and the relevant infected disease has been named as coronavirus disease 2019 (COVID-19) by the World Health Organization, respectively. The COVID-19 epidemic is spreading in China and all over the world now. The purpose of this review is primarily to review the pathogen, clinical features, diagnosis, and treatment of COVID-19, but also to comment briefly on the epidemiology and pathology based on the current evidence. © 2020 The Authors. Journal of Medical Virology published by Wiley Periodicals Inc.