https://www.selleckchem.com/MEK.html Despite the natural recurrence and constancy of drought phenomena in the region, water management policies have often based the building of disproportionate and costly water infrastructure works. Cumulative multi-annual analysis of the outputs of drought monitoring can be an early warning system for water basins, regions, or municipalities, notably those who usually live with recurrent highly severe droughts, and remain neglected upon a remarkable vulnerability. This approach also supports proactive and preventive drought management instead of the usual emergency crisis management model.Currently, the neuropathological diagnosis of Lewy body disease (LBD) may be stated according to several staging systems, which include the Braak Lewy body stages (Braak), the consensus criteria by McKeith and colleagues (McKeith), the modified McKeith system by Leverenz and colleagues (Leverenz), and the Unified Staging System by Beach and colleagues (Beach). All of these systems use semi-quantitative scoring (4- or 5-tier scales) of Lewy pathology (LP; i.e., Lewy bodies and Lewy neurites) in defined cortical and subcortical areas. While these systems are widely used, some suffer from low inter-rater reliability and/or an inability to unequivocally classify all cases with LP. To address these limitations, we devised a new system, the LP consensus criteria (LPC), which is based on the McKeith system, but applies a dichotomous approach for the scoring of LP (i.e., "absent" vs. "present") and includes amygdala-predominant and olfactory-only stages. α-Synuclein-stained slides from brainstem, limbic system, neocoof neocortical LP according to the LPC system was associated with a 5.9 OR (p  less then  0.0001) of dementia in the 134 NBTR cases and a 3.14 OR (p = 0.0001) in the 202 UPBB cases. We established that the LPC system has good reproducibility and allows classification of all cases into distinct categories. We expect that it will be reliable and