05; d's = 0.08-0.37) with larger within-group effect sizes (d's = 0.48-0.61) than in control (d's = 0.26-0.54). Despite a small sample size, this one-session intervention offers promise among a high-risk group of drinkers with emotional vulnerabilities. The computer-based format may allow for mass distribution of a low-cost intervention in the future; however, follow-up testing in larger samples is needed.The use of coal in Chinese households for winter heating emits harmful pollutants that severely affect indoor air quality and climate. Therefore, China has made efforts to transition into clean heating using improved heating stoves and biomass pellets. Although the economic and policy implications of such demonstration projects have been extensively investigated, little has been done to understand the real-world performance and adoption trends of such stoves. This study measured in-use emissions from nine different pellet stoves used for heating among 52 rural households in Yangxin, Shandong Province. The temperature of the stove chimney of 21 households was monitored and 56 households were surveyed to explore the stove use trend. The particulate and gaseous emission concentrations for most of the stoves exceeded the limits specified in the Chinese national standard. The measured fuel energy-based emission factors (mean ± standard deviation) for CO2, CO, NOx, and PM2.5 were 103 ± 3, 1.41 ± 1.19, 0.336 ± 0.237, and 0.146 ± 0.108 g/MJ, respectively. Between January to February, the average daily heating duration was 8.71 h, and the sustained use of heating stoves was seen among over 85% of the households. On average, the households used their heating stoves for 3.28 months and the estimated annual pellets consumption for a household was 2.7 tons. Besides inherent variabilities associated with user habits, the stove's design-related shortcomings and low-grade pellets hindered the performance and effectiveness of pellet stoves. This study provides insights into opportunities and challenges for the promotion of cleaner fuels and heating technologies. Furthermore, it will provide information on emissions from rural residential sources to build the emission inventory and inform policymaking for successful stove promotion programs.Progranulin (PGRN) and neuroinflammatory markers increased over the course of Alzheimer's disease (AD). We aimed to determine whether neuroinflammation could modulate the association of PGRN with amyloid pathologies. Baseline cerebrospinal fluid (CSF) PGRN and AD pathologies were measured for 965 participants, among whom 228 had measurements of CSF neuroinflammatory markers. Causal mediation analyses with 10,000 bootstrapped iterations were conducted to explore the mediation effects within the framework of A/T/N biomarker profile. Increased levels of CSF PGRN and inflammatory markers (sTNFR1, sTNFR2, TGF-β1, ICAM1, and VCAM1) were associated with T- or N-positive (TN+) profile, irrespective of the amyloid pathology. In TN+ group, CSF PGRN was associated with increased levels of these inflammatory markers and CSF amyloid-β1-42 (p less then 0.01). The neuroinflammatory markers significantly modulated (proportion 20%~60%) the relationship of amyloid burden with CSF PGRN, which could predict slower cognitive decline and lower AD risk in the TN+ group. The abovementioned associations became non-significant in the TN- group. These findings revealed a close relationship between neuroinflammation and CSF PGRN in contributing to AD pathogenesis, and also highlighted the specific roles of PGRN in neurodegenerative conditions. Future experiments are warranted to verify the causal relationship.Cerebral microbleeds (MBs) increase at later ages in association with increased cognitive decline and Alzheimer Disease (AD). MB prevalence is also increased by APOE4 and hypertension. In EFAD mice (5XFAD+/-/human APOE+/+), cerebral cortex MBs are most prevalent in E4 females at 6 months, paralleling plaque amyloid. We evaluated MBs at 2, 4, and 6 months in relation to amyloid in plaques and cerebral amyloid angiopathy (CAA) by age, sex, APOE allele, and blood pressure. At 2 mo, MBs were 50% more numerous than plaques, followed by decreased ratio of MBsAβ plaques with female excess to 6 mo. The stable size of MBs suggests MBs arise as single events of extravasation, which may "seed" plaque formation. Blood pressure was normal from 2 to 6 months, minimizing a role of hypertension. Memory, assessed by fear conditioning, decreased with age in correlation with MBs and amyloid. Cortical layer analysis showed prevalent MBs and plaque in layers 4 and 5. Contrarily, CAA was prevalent in layers 1 and 2, discounting its contribution to MBs.
  This paper aims to provide a quantitative estimation of the representation of diseases defined as rare today in the bioarchaeological literature and to outline the reasons for this.
 
  A 45-year bibliometric study of publications in seven bioarchaeological journals, along with two journals and editorial groups of broader scientific focus.
 
  Analyses of distribution patterns of the search hits and diachronic trends for achondroplasia, autosomal-dominant osteopetrosis, osteogenesis imperfecta, and osteopoikilosis, compared to those for tuberculosis as control measure of coverage.
 
  Studies of ancient rare diseases (ARD) are mostly published as case reports in specialized journals and their number did not benefit from the introduction of biomolecular studies.  https://www.selleckchem.com/products/oxidopamine-hydrobromide.html  The higher frequency of cases of achondroplasia suggests that not all rare diseases are equally under-represented.
 
  Rare diseases are still largely under-represented in bioarchaeological literature. Their marginality likely results from a combination of taphonomic, methodological and public visibility factors.
 
  This article is the first attempt to provide a quantitative assessment of the under-representation of ARD and to outline the factors behind it.
 
  Rare diseases are an etiologically heterogeneous group. The number of surveyed journals and articles, as well as targeted diseases might be limiting factors.
 
  Increasing collection and dissemination of data on ARD; opening a wide-ranging debate on their definition; implementation of biomolecular studies.
 Increasing collection and dissemination of data on ARD; opening a wide-ranging debate on their definition; implementation of biomolecular studies.