In this study, we will look at the proposed health effects of fasting and its impact on the immune system, the effects of Ramadan intermittent fasting on resting values and responses of immunological/antioxidant biomarkers in elite and recreational athletes, together with the important health, nutrition, and exercise advice that fasting people need to follow in the event of a COVID-19 outbreak.Despite the extreme importance of food intake in human health, it is currently difficult to conduct an objective dietary assessment without individuals' self-report. In recent years, a passive method utilizing a wearable electronic device has emerged. This device acquires food images automatically during the eating process. These images are then analyzed to estimate intakes of calories and nutrients, assisted by advanced computational algorithms. Although this passive method is highly desirable, it has been thwarted by the requirement of a fiducial marker which must be present in the image for a scale reference. The importance of this scale reference is analogous to the importance of the scale bar in a map which determines distances or areas in any geological region covered by the map. Likewise, the sizes or volumes of arbitrary foods on a dining table covered by an image cannot be determined without the scale reference. Currently, the fiducial marker (often a checkerboard card) serves as the scale reference which must be present on the table before taking pictures, requiring human efforts to carry, place and retrieve the fiducial marker manually. In this work, we demonstrate that the fiducial marker can be eliminated if an individual's dining location is fixed and a one-time calibration using a circular plate of known size is performed. When the individual uses another circular plate of an unknown size, our algorithm estimates its radius using the range of pre-calibrated distances between the camera and the plate from which the desired scale reference is determined automatically. Our comparative experiment indicates that the mean absolute percentage error of the proposed estimation method is ~10.73%. Although this error is larger than that of the manual method of 6.68% using a fiducial marker on the table, the new method has a distinctive advantage of eliminating the manual procedure and automatically generating the scale reference.Background Several studies suggest an increased incidence of thrombosis in COVID-19 patients. However, evidence on how to prevent and even treat it is scarce. The aim of this study was to compare the cumulative incidence of venous thromboembolism (VTE) of two different methods for lower extremity deep vein thrombosis (LE-DVT) diagnosis systematic vs. clinically guided complete compression venous ultrasonography (CCUS). We conducted a monocentric, prospective, open-label, non-randomized study. All consecutive patients admitted in three intensive care units (ICUs) of University Hospital of Toulouse for COVID-19 pneumonia were included one performed systematic screening for LE-DVT, the others did not. The primary outcome was the 21-day cumulative incidence of VTE. The secondary end points were the 21-day cumulative incidences of major bleeding and death. Results Among the 78 patients included, 27 (34.6%) underwent systematic screening for DVT 7 ± 2 days after ICU admission. Thirty-two patients (41.0%) were diagnosed with VTE, with a 21-day cumulative incidence of 42.3% (95% CI, 31.4-55.2), without difference between screened and non-screened patients (hazard ratio 1.45, 95% CI, 0.72-2.93). In the screened group, the frequency of isolated DVT was higher (25.9 vs. 5.9%, p-value = 0.027), but the frequency of pulmonary embolism was not reduced (25.9 vs. 29.4%, p-value = 0.745). The 21-day cumulative incidences of major bleeding and death were 9.6% (95% CI, 4.7-19.2) and 10.3% (95% CI, 5.0-20.8), respectively, without difference between the two groups. Conclusions A systematic screening for DVT in patients hospitalized in ICU was not associated with a higher diagnosis of VTE or a reduced diagnosis of PE.Background Electrical storm (ES) has profound psychological effects and is associated with a higher mortality in patients with implantable cardioverter-defibrillator (ICD). Assessing the incidence and features of ES, is vital. Previous studies have shown winter peaks for ventricular tachyarrhythmia (VTA) in ICD patients. However, the effects of heat with a high relative humidity remain unclear. Thus, this study aimed to assess the nonlinear and lagged effects of apparent temperature [or heat index (HI)] on VTA among patients with and without ES after ICD implantation. Methods Of 626 consecutive patients who had ICDs implanted from January 2004 to June 2017 at our hospital, 172 who experienced sustained VTAs in ICD recording were analyzed, and their clinical records were abstracted to assess the association between VTA incidence and HI by time-stratified case-crossover analysis.  https://www.selleckchem.com/products/nivolumab.html  Cubic splines were used for the nonlinear effect of HI, with adjustment for air pollutant concentrations. Results A significant seasonal effect for ES patients was noted. Apparent temperature, but not ambient temperature, was associated with VTA occurrences. The low and high HI thresholds for VTA incidence were 30°C, respectively, with a percentage change in odds ratios of 1.06 and 0.37, respectively, per 1°C. Lagged effects could only be demonstrated in ES patients, which lasted longer for low HI (in the next 4 days) than high HI (in the next 1 day). Conclusion VTA occurrence in ICD patients was strongly associated with low HI and moderately associated with high HI. Lagged effects of HI on VTA were noted in patients with ES. Furthermore, patients with ES were more vulnerable to heat stress than those without ES. Patients with ICD implantation, particularly in those with ES, should avoid exposure to low and high HI to reduce the risk of VTAs, improve quality of life and possibly reduce mortality.Background Several dermoscopic features of juvenile xanthogranuloma (JXG) have been previously described in single cases or small case series and need to be further verified in a large sample. Objective We aimed to investigate the dermoscopic patterns of JXG in a large case series and the correlations of these with clinical features of different histopathological subtypes of JXG. Methods Patients who underwent dermoscopic evaluation and had a histopathological diagnosis of JXG were recruited. Histological findings, including stage and Ki67 proliferative index and the dermoscopic features of each lesion were recorded. Results Forty-one patients with JXG were included. The male to female ratio was 1.28 1 and the median age of onset was 11 months (range 0-95 months). Fourteen lesions were histologically categorized in the early stage, 17 in the developed stage, and 10 in the late stage. The "setting sun" pattern was observed in 35 lesions (85.4%) and "clouds" of paler yellow areas in 26 lesions (63.4%). The frequency of the "setting sun" pattern was higher in the early and developed stages (30/31) than in the late stage (5/10) (P = 0.