https://www.selleckchem.com/products/FK-506-(Tacrolimus).html The type of starch and plasticizer significantly influenced the environmental load of the production of the composites. The main drivers of these differences were the multiple agricultural practices, such as irrigation and fertilization, and the crop efficiency for starch extraction. Sorbitol was found to be many times more impacting than glycerol in most categories, which is due to the complex processing of sorbitol and high content in biocomposites with similar mechanical properties than glycerol. Additionally, Brazil nut fibers are presented as an eco-friendly and low-burden natural filler due to their easy processing and agricultural waste origin. The limitations, applications, and significance of the results were discussed.The ever-increasing use of synthetic hormones, especially progestins, for medical applications has drawn growing concerns due to their potential endocrine disrupting effects that may diminish the reproductive outputs of aquatic organisms. Using mosquitofish (Gambusia affinis) as a model species, we tested whether gestodene (GES), a commonly used progestin, can alter the expressions of genes associated with sex hormone synthesis and cause ensuing changes in morphological features, courtship behaviour and oocyte development. After exposing to GES at environmentally relevant concentrations (2.96, 32.9 and 354 ng L-1) for 40 days, we found that GES, especially at 354 ng L-1, induced masculinization of female fish, indicated by the reduced body weight to length ratio and development of gonopodia (i.e. anal fins of male fish). Thus, the males showed less intimacy and mating interest towards the GES-exposed females, indicated by the reduced time spent on attending, following and mating behaviours. While oocyte development was seemingly unaffected by GES, spermatogonia were developed in the ovary. All the aforementioned masculinizing effects of GES were associated with the increased testos