liative healthcare staff.
  The objective of this scoping review is to map different past and present legal approaches and government policies that have an intended or unintended effect on the ongoing overdose epidemic.
 
  In response to the current overdose epidemic, a number of different legal approaches and government policies have been implemented regarding prescription drugs, illicit substances, and drug use. Additionally, other legal approaches and government policies that do not directly target the overdose crisis (e.g. cannabis legalization) may have unintentional effects on opioid use-related harms. The findings of this review will inform policy-makers and individuals working at the forefront of the overdose crisis to help them anticipate the consequences of legal approaches already in place or those that have been recently implemented.
 
  This review will include all legal approaches or government policies that have an intended or unintended effect on the overdose epidemic or on opioid use-related harms or mortality. Only studies published in English from 2000 onward will be included.
 
  We will search health sciences databases, legal databases, and social sciences databases to ensure comprehensive identification of studies across disciplines. Two independent team members will screen titles and abstracts, and review full-text articles for potential inclusion. One team member will extract data for all studies, and a second team member will verify the data extraction. The results will be presented as a narrative synthesis and in tabular or diagrammatic form.
 We will search health sciences databases, legal databases, and social sciences databases to ensure comprehensive identification of studies across disciplines. Two independent team members will screen titles and abstracts, and review full-text articles for potential inclusion. One team member will extract data for all studies, and a second team member will verify the data extraction. The results will be presented as a narrative synthesis and in tabular or diagrammatic form.
  This scoping review aims to fill a gap in knowledge on terminology and descriptions of services that connect children with neurodisability and their families to needed supports in the community.
 
  Children with neurodisability represent a significant population with a demonstrated need for coordinated support. Patient navigation is a concept that was founded on the principles of coordinating care for patients based on individual needs. Despite the history of patient navigation, a definition for the concept itself is lacking. Moreover, children with neurodisability and their families are not often the target population of such initiatives. It is not known whether existing terminology and descriptions encompass the particular needs of children with neurodisability and their families.
 
  This review will examine published, peer-reviewed articles related to navigation as intended for children under the age of 18 with neurodisability, and their families. All eligible studies pertaining to this context will be examined.
 
  A preliminary search was completed to find initial search terms, upon which a full search strategy was developed.  https://www.selleckchem.com/products/atogepant.html  Search results yielded from PubMed (NCBI), MEDLINE (Ovid) and CINAHL (EBSCO) were screened to ensure articles were peer-reviewed, published in English in or after 1990, and relevant to both children with neurodisability/their families and navigation-related resources. A full-text review of relevant articles will be conducted and data extracted using the included extraction tool. Extracted terminology and concepts will be analyzed using a modified grounded theory approach, which will inform a working definition of navigational services and related terms.
 
  Registered in Open Science Framework.
 Registered in Open Science Framework.
  The objective of this review is to evaluate the efficacy of group social skills interventions in improving social knowledge, social competency, and social participation in adolescents with acquired and developmental disabilities.
 
  Difficulties with social functioning and participation are commonly experienced by adolescents with a range of acquired and developmental disabilities. There is evidence for the use of group social skills interventions in youth with autism spectrum disorder, although less is known about their efficacy with youth with other disabilities.
 
  This review will include studies that evaluate group social skills interventions in adolescents with an acquired or developmental disability, excluding a primary mental health disorder. Randomized control trials will be the only experimental design included and group social skills interventions must have an available intervention manual to allow use in clinical practice. Primary outcomes will include measures of social knowledge, social competence, and social participation.
 
  PubMed, CINAHL, Embase, Cochrane Register of Controlled Trials, PsycINFO and Web of Science will be searched for eligible studies published in English. Clinical Trials Registry, Google Scholar, and ProQuest Dissertation and Theses will also be searched. Screening, study selection, critical appraisal, and data extraction will be conducted by two independent reviewers using standardized tools. Studies will be pooled, where possible, with statistical meta-analysis and the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) Summary of Findings presented.
 
  The protocol for this systematic review has been submitted to PROSPERO.
 The protocol for this systematic review has been submitted to PROSPERO.
  To determine the effectiveness of nitric oxide agents in modifying the metabolic factors of pre-eclampsia and its effectiveness in preventing the onset of pre-eclampsia in high-risk pregnancies.
 
  Pre-eclampsia is a major cause of maternal death during the prenatal and neonatal periods. Nitric oxide is a vasodilator and platelet aggregation inhibitor responsible for the vascular adaptation of the placenta. Although various studies have established that nitric oxide is effective in preventing complications from pre-eclampsia, there is limited evidence to show that administering nitric oxide agents to the high-risk women before 20 weeks' gestation will prevent the onset of pre-eclampsia.
 
  This review will consider randomized controlled trials that compare nitric oxide donors and precursors with a placebo or no intervention on pregnant women (18 to 44 years) with ≤ 20-week gestational age that are at high risk of pre-eclampsia. The primary outcome of interest will be the onset of pre-eclampsia. Secondary outcomes include increased systolic and diastolic blood pressure, elevated asymmetric dimethylarginine levels, decreased endothelial nitric oxide synthase activity, reduced maternal placental vasculature, and abnormal Doppler ultrasound waveforms.